Combination of ranibizumab and navigated retinal photocoagulation in diabetic macular edema, compared to ranibizumab mono-therapy: Twelve month results

2013 ◽  
Vol 91 ◽  
pp. 0-0
Author(s):  
M KERNT
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Retinal Photocoagulation

scholarly journals Conbercept and Retinal Photocoagulation in the treatment of Diabetic Macular Edema

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Weizhe Meng ◽  
Ronghua Li ◽  
Xiufen Xie
Keyword(s):  
Macular Edema ◽  
Intravitreal Injection ◽  
Diabetic Macular Edema ◽  
Laser Photocoagulation ◽  
Retinal Nerve Fibre Layer ◽  
Macular Thickness ◽  
Control Group ◽  
Panretinal Photocoagulation ◽  
Observation Group ◽  
Retinal Photocoagulation

Objective: To explore the clinical efficacy of intravitreal injection of conbercept in combination with retinal laser photocoagulation in the treatment of diabetic macular edema. Methods: Ninety patients with diabetic macular edema were selected and grouped into an observation group and a control group using random number table, 45 patients (45 eyes) each group. The control group was given retinal laser photocoagulation, while the observation group was given intravitreal injection of Conbercept on the basis of panretinal photocoagulation. The Best Corrected Visual Acuity (BCVA), thickness of retinal nerve fibre layer (RNFL) and macular thickness were measured through relevant examinations before and after treatment. The intraocular pressures of patients in the two groups were evaluated, and moreover the complications were recorded. Results: The RNFL thickness and macular thickness of the two groups had no statistically significant differences before treatment (P>0.05) and decreased significantly after treatment; the decrease amplitude of the observation group was significantly larger than that of the control group (P<0.05). The BCVA of both groups significantly increased in the 1st, 2nd and 4th week after treatment (P<0.05); the increase amplitude of BCVA of the observation group was more significant than that of the control group at different time points after treatment (P<0.05). The intraocular pressure of the observation group was not significantly different with that of the control group in the 1st, 2nd and 4th week after treatment (P>0.05). There were no severe eye complications and systemic adverse reactions in both groups in the process of follow up. Conclusion: Intravitreal injection of conbercept in combination with retinal laser photocoagulation performs better in improving the BCVA and central macular thickness of patients with diabetic macular edema compared to retinal laser photocoagulation and has high safety. doi: https://doi.org/10.12669/pjms.35.6.512 How to cite this:Meng W, Li R, Xie X. Conbercept and Retinal Photocoagulation in the treatment of Diabetic Macular Edema. Pak J Med Sci. 2019;35(6):1493-1498. doi: https://doi.org10.12669/pjms.35.6.512 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Role of focal laser retinal photocoagulation in treatment of diabetic macular edema

2021 ◽  
Vol 38 (2) ◽  
pp. 56-69
Author(s):  
I. V. Ionkina ◽  
A. G. Grinev ◽  
O. M. Zherebtsova
Keyword(s):  
Macular Edema ◽  
Laser Therapy ◽  
Diabetic Macular Edema ◽  
Laser Photocoagulation ◽  
Current Evidence ◽  
Adjunct Therapy ◽  
Anti Vegf ◽  
Laser Systems ◽  
Retinal Photocoagulation

Vascular endothelial growth factor (anti-VEGF) inhibitors in action have demonstrated efficacy and safety in the treatment of diabetic macular edema (DME), and have changed both the goal and prospects for treatment of this disease. Consequently, the role of focal laser retinal photocoagulation in the treatment of DME has been actively debated. However, technical advances in new laser systems, treatment protocols for anti-VEGF drug research, and the functional impact of modern focal photocoagulation are necessary to assess the role of laser coagulation in the treatment of DME. A wide range of clinical studies of laser therapy was necessary as an additional treatment for 20 to 50 % of patients receiving monotherapy with anti-VEGF drugs in patients with diabetic macular edema. In addition, a lower frequency of repeated treatment and a more stable reduction in retinal thickness have been demonstrated in other studies. However, the lack of information about the laser systems used, their technical characteristics, and application protocols often make it difficult to compare directly the results of anti-VEGF tests. Therefore, the aim of our work was to analyze the currently available data related to the potential role of focal laser photocoagulation in the treatment of DME, including a detailed review of the most commonly used laser systems. The results obtained with sub-threshold diode micro-pulse laser photocoagulation may be a valuable option as an adjunct therapy to treatment with angiogenesis inhibitors. Current evidence suggests that focal laser therapy should still exist as an adjunct therapy for many patients.

scholarly journals Transient Increase and Delay of Multifocal Electroretinograms Following Laser Photocoagulations for Diabetic Macular Edema

2021 ◽  
Vol 10 (2) ◽  
pp. 357
Author(s):  
Yoshiaki Shimada ◽  
Masayuki Shibuya ◽  
Kei Shinoda
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Case Series ◽  
Transient Increase ◽  
Implicit Time ◽  
Physiological Changes ◽  
Case Series Study ◽  
Multifocal Electroretinograms ◽  
Series Study ◽  
Retinal Photocoagulation

Background: The acute physiological changes induced by focal retinal photocoagulation (PC) have been largely unexplored. Methods: This was a case-series study. We recorded multifocal electroretinograms (mfERGs) just before PC, and mfERGs were also recorded 5′, 15′, one hour, 24 h, and one week after the PCs. Transient changes of mfERGs were analyzed in eyes which underwent PCs to treat diabetic macular edema. The mfERGs recorded from the predominantly irradiated area and that from non-irradiated areas were analyzed separately. Results: Fifteen eyes of 15 patients were included in this study. The mfERGs elicited from non-irradiated areas did not change after PC, but the mfERGs elicited from the irradiated area changed with time; the amplitude was larger at 60′ than that before (p < 0.05) and at 5′ after PC (p < 0.01) and significantly smaller at 24 h and 1 week than that before and at 60′ after the PC (p < 0.01). The implicit time was significantly prolonged after PC. mfERG on irradiated area with the severe diabetic change was less altered after PCs. Conclusions: The transient increase in the amplitude at 60′ likely resulted from a biological amplification of partially damaged cells adjacent to the PC spots. The mfERGs manifested the dynamic alterations of the retinal function following PCs.

Effect of Retinal Photocoagulation on Intraretinal Lipid Exudates in Diabetic Macular Edema Documented by Optical Coherence Tomography

Ophthalmology ◽  
2010 ◽  
Vol 117 (4) ◽  
pp. 773-779 ◽  
Author(s):  
Gábor Gy Deák ◽  
Matthias Bolz ◽  
Katharina Kriechbaum ◽  
Sonja Prager ◽  
Georgios Mylonas ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Optical Coherence ◽  
Retinal Photocoagulation

scholarly journals Targeted Retinal Photocoagulation for Diabetic Macular Edema with Peripheral Retinal Nonperfusion

Ophthalmology ◽  
2018 ◽  
Vol 125 (5) ◽  
pp. 683-690 ◽  
Author(s):  
David M. Brown ◽  
William C. Ou ◽  
Tien P. Wong ◽  
Rosa Y. Kim ◽  
Daniel E. Croft ◽  
...  
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Retinal Photocoagulation

scholarly journals Conventional and Pattern Laser Applications in Diabetic Retinopathy and Diabetic Macular Edema

2018 ◽  
pp. 170-176
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Age Groups ◽  
Laser Applications ◽  
Loss Of Vision ◽  
Advantages And Disadvantages ◽  
Pan Retinal Photocoagulation ◽  
Retinal Photocoagulation

Diabetes mellitus leads to two major complications, diabetic retinopathy (DRP) and diabetic macular edema (DME), resulting in loss of vision. Diabetes mellitus is the most common cause of loss of vision when all age groups are taken into account. However, this complication can be prevented or delayed with various treatments, especially strict blood glucose regulation. Laser, anti-VEGF, and corticosteroids are used in the treatment of DME. Laser therapy is applied as a focal / grid or pan-retinal photocoagulation. Nowadays, different lasers are presented to use in the treatment in DRP and DME. Each has different advantages and disadvantages. This article discusses the characteristics of lasers used in the treatment of DRP and DME.

Sign in / Sign up

Export Citation Format

Share Document