Decrease in aspirin-induced gastric mucosal damage in rats by oral administration of the cytotoxic drugs melphalan and methotrexate

1980 ◽  
Vol 32 (1) ◽  
pp. 544-546 ◽  
Author(s):  
D. A. BERSTOCK ◽  
G. J. FRANK ◽  
I. F. STAMFORD ◽  
A. BENNETT
Keyword(s):  
Oral Administration ◽  
Mucosal Damage ◽  
Cytotoxic Drugs ◽  
Gastric Mucosal Damage

Cyperus rotundus L. prevents non-steroidal anti-inflammatory drug-induced gastric mucosal damage by inhibiting oxidative stress

2015 ◽  
Vol 26 (5) ◽  
Author(s):  
Deepa Thomas ◽  
Sindhu Govindhan ◽  
Edathiruthykottuckkal Chandran Baiju ◽  
Ganesan Padmavathi ◽  
Ajaikumar B. Kunnumakkara ◽  
...  
Keyword(s):  
Oral Administration ◽  
Mucosal Damage ◽  
Cyperus Rotundus ◽  
Gastric Mucosal Damage ◽  
Ulcer Index ◽  
Drug Induced ◽  
Single Oral Administration ◽  
Tissue Lipid Peroxidation ◽  
Fasted Rats ◽  
Different Doses

AbstractSince centuries,Seventy percent methanolic extract of the plant was prepared and fed to 36-h fasted rats. Ulcer was induced in these rats by single oral administration of aspirin (400 mg/kg) 1 h after the administration of the plant extract. After 4 h, the rats were sacrificed, ulcer index was calculated, and antioxidant activity of the extract in gastric mucosa was evaluated by determining the levels of superoxide dismutase, glutathione, glutathione peroxidase, and tissue lipid peroxidation.Oral administration of different doses ofOur results showed that

Protective effects of ethanol extract of a Mexican propolis on indomethacin-induced gastric mucosal damage in mice.

2019 ◽  
Author(s):  
DV Pilar ◽  
VVS Ibran ◽  
RC Mario ◽  
CA Octavio ◽  
MM Canales-Martinez ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

Nonprotein sulfhydryl compounds in canine gastric mucosa: effects of PGE2 and ethanol

1985 ◽  
Vol 249 (1) ◽  
pp. G137-G144 ◽  
Author(s):  
T. A. Miller ◽  
D. Li ◽  
Y. J. Kuo ◽  
K. L. Schmidt ◽  
L. L. Shanbour
Keyword(s):  
Gastric Mucosa ◽  
Low Dose ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
High Dose ◽  
Mucosal Protection ◽  
Gastric Mucosal Protection ◽  
Sulfhydryl Compounds ◽  
Mild Irritants

By use of an in vivo canine chambered stomach preparation in which the gastric mucosa was partitioned into two equal halves, the effect of topical 16,16-dimethyl PGE2 (DMPGE2) (1 microgram/ml of perfusate) and 8% and 40% ethanol on tissue levels of nonprotein sulfhydryl compounds was assessed. Both DMPGE2 and 8% ethanol significantly increased (P less than 0.005) mucosal levels of nonprotein sulfhydryls when compared with corresponding mucosa bathed with saline alone. In contrast, mucosa bathed with 40% ethanol showed significantly decreased levels. If mucosa was bathed with DMPGE2 or 8% ethanol prior to exposing the stomach to 40% ethanol, this depletion in sulfhydryl compounds was not observed. Since other experimental observations have shown that exogenously administered prostaglandins and mild irritants (such as low-dose alcohol) can prevent gastric mucosal damage by necrotizing agents (such as high-dose alcohol), our findings are consistent with the hypothesis that nonprotein sulfhydryls may play a role in mediating gastric mucosal protection.

Role of Lipoxygenases and the Lipoxin A4/Annexin 1 Receptor in Ischemia-Reperfusion-Induced Gastric Mucosal Damage in Rats

Pharmacology ◽  
2009 ◽  
Vol 84 (5) ◽  
pp. 294-299 ◽  
Author(s):  
Brigitta M. Peskar ◽  
Karlheinz Ehrlich ◽  
Rufina Schuligoi ◽  
Bernhard A. Peskar
Keyword(s):  
Ischemia Reperfusion ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Lipoxin A4 ◽  
Annexin 1

A new in vitro model for ethanol-induced gastric mucosal damage

1999 ◽  
Vol 41 (4) ◽  
pp. 167-172 ◽  
Author(s):  
Yassir M.Al-Mulla Hummadi ◽  
Rafid A Najim ◽  
Imad B Farjou
Keyword(s):  
In Vitro Model ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Vitro Model
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