Transdermal delivery of zidovudine (AZT) through rat skin: Optimization of a suitable delivery vehicle

Composite nanoparticles composed of an anionic phospholipid of 1,2-dipalmitoyl-sn-glycero-3-phosphorylglycerol (DPPG) and paclitaxel (PTX) were successfully prepared by mixing them in water followed by a subsequent heating/cooling process. The size of DPPG-PTX nanoparticle could be easily tuned by ultrasonic fragmentation. Upon addition of small-sized fluorescently labeled paclitaxel (FLPTX) nanoparticles with DPPG (DPPG-FLPTX) to rat skin tissue, part of the FLPTX molecules permeated to the stratum corneum.

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In vivomicrodialysis for the evaluation of transfersomes as a novel transdermal delivery vehicle for cinnamic acid

Drug Development and Industrial Pharmacy ◽

10.3109/03639045.2012.756888 ◽

2013 ◽

Vol 40 (3) ◽

pp. 301-307 ◽

Cited By ~ 7

Author(s):

Yong-Tai Zhang ◽

Yue-Ming Xu ◽

Su-Juan Zhang ◽

Ji-Hui Zhao ◽

Zhi Wang ◽

...

Keyword(s):

Cinnamic Acid ◽

Transdermal Delivery ◽

Delivery Vehicle

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Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2003.11.004 ◽

2004 ◽

Vol 271 (1-2) ◽

pp. 155-165 ◽

Cited By ~ 48

Author(s):

R.J Babu ◽

J.K Pandit

Keyword(s):

Transdermal Delivery ◽

Rat Skin

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Transdermal diffusion of xenon from lipophilic solution of capric triglyceride and from water

Dermatology and Dermatitis ◽

10.31579/2578-8949/037 ◽

2018 ◽

Vol 2 (5) ◽

pp. 01-04

Author(s):

Collin Jared ◽

Diego Luis ◽

Jonathan Noah ◽

Benjamin Dylan

Keyword(s):

Phase Boundary ◽

Diffusion Coefficients ◽

Transdermal Delivery ◽

Permeability Coefficient ◽

Pharmaceutical Products ◽

Rat Skin ◽

Adult Rats ◽

Franz Diffusion Cells ◽

Phosphate Buffered Saline

Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water. Methods: Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6). Results: Xenon flux (JXe) through skin from the lipophilic solution was 0.036 mg/hour×cm2 and permeability coefficient (Kp) was 0.003 cm/h; JXe through skin from water was 0.029 mg/h×cm2 and the Kp was 0.002 cm/h. Total time for xenon diffusion through skin from lipophilic solution and from water was ~2 h. Conclusion: The study presents the first characterization of xenon diffusion through rat skin from multiphase solutions to PBS. These data may be useful for the development of xenon-rich pharmaceutical products for external use.

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Transdermal Delivery of Verapamil HCl: Effect of Penetration Agent on In Vitro Penetration through Rat Skin

Journal of Applied Pharmaceutical Science ◽

10.7324/japs.2013.30309 ◽

2013 ◽

Author(s):

Jatin Sood

Keyword(s):

Transdermal Delivery ◽

Rat Skin ◽

Verapamil Hcl

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Transfersome vs liposomes as drug delivery vehicle for the treatment of skin cancers

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10i3.1375 ◽

2019 ◽

Vol 10 (3) ◽

pp. 1795-1807

Author(s):

Sivarajakumar Raahulan ◽

Bharat Kumar Reddy Sanapalli ◽

Sai Kiran SS. Pindiprolu ◽

Veera Venkata Satyanarayana Reddy Karri

Keyword(s):

Skin Cancer ◽

Transdermal Delivery ◽

Drug Carrier ◽

Current Treatment ◽

Delivery Vehicle ◽

Preparation Methods ◽

Regulatory Aspects ◽

Skin Delivery ◽

Skin Cancers ◽

Target Effects

Skin cancer is one of the leading causes of cancer-related deaths worldwide. It is estimated that by 2030, there will be around 13.1million deaths can occur due to skin cancer. Current treatment of skin cancer includes surgery, radiation and chemotherapy. Chemo-resistance, off-target effects and poor bioavailability are the major challenges for currently available drugs for the treatment of skin cancer. Transfersomes is a novel, elastic vesicular drug carrier composed of phospholipids, surfactants and ethanol for enhanced transdermal delivery. This article we have reviewed about merits/demerits, liposomes vs transfersomes, preparation methods, characterization, mechanism of skin delivery, and application and regulatory aspects of transfersomes in treating various skin cancers.

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Piceid Nanoparticles Stabilized by Anionic Phospholipids for Transdermal Delivery

Natural Product Communications ◽

10.1177/1934578x20925578 ◽

2020 ◽

Vol 15 (5) ◽

pp. 1934578X2092557

Author(s):

Noriyuki Uchida ◽

Masayoshi Yanagi ◽

Hiroki Hamada

Keyword(s):

Stratum Corneum ◽

Inhibitory Activity ◽

Transdermal Delivery ◽

Rat Skin ◽

Cooling Process ◽

Anionic Phospholipid ◽

Tyrosinase Inhibitory Activity ◽

Anionic Phospholipids ◽

Prepared Composite ◽

Resveratrol Derivative

Piceid, stilbenoid glucoside, is a representative resveratrol derivative. Because of a high tyrosinase inhibitory activity of piceid through resveratrol derivatives, transdermal delivery of piceid has been desired for taking advantage of the activity. Here we successfully prepared composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl- sn-glycero-3-phosphorylglycerol (DPPG) and piceid by mixing them in water and a subsequent heating/cooling process. When small-sized fluorescently labeled DPPG-piceid (DPPG-FLpiceid) nanoparticles were added to rat skin tissue, FLpiceid molecules were localized in stratum corneum.

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