Piceid Nanoparticles Stabilized by Anionic Phospholipids for Transdermal Delivery
Keyword(s):
Rat Skin
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Piceid, stilbenoid glucoside, is a representative resveratrol derivative. Because of a high tyrosinase inhibitory activity of piceid through resveratrol derivatives, transdermal delivery of piceid has been desired for taking advantage of the activity. Here we successfully prepared composite nanoparticles composed of anionic phospholipid of 1,2-dipalmitoyl- sn-glycero-3-phosphorylglycerol (DPPG) and piceid by mixing them in water and a subsequent heating/cooling process. When small-sized fluorescently labeled DPPG-piceid (DPPG-FLpiceid) nanoparticles were added to rat skin tissue, FLpiceid molecules were localized in stratum corneum.
2021 ◽
Vol 16
(3)
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pp. 1934578X2110026
Keyword(s):
2017 ◽
Vol 1
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pp. 239784731772319
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