scholarly journals Characterization of carbapenem‐resistant Klebsiella pneumoniae in a tertiary hospital in Fuzhou, China

2020 ◽  
Vol 129 (5) ◽  
pp. 1220-1226
Author(s):  
D. Chen ◽  
H. Li ◽  
Y. Zhao ◽  
Y. Qiu ◽  
L. Xiao ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Tertiary Hospital ◽  
Carbapenem Resistant

scholarly journals Molecular Characterization of Carbapenem-resistant, Colistin-resistant Klebsiella pneumoniae Isolates from a Tertiary Hospital in Jeonbuk, Korea

2021 ◽  
Vol 51 (3) ◽  
pp. 120-127
Author(s):  
Tae Hee Lee ◽  
Minhyeon Cho ◽  
Jaehyeon Lee ◽  
Joo-Hee Hwang ◽  
Chang-Seop Lee ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Characterization ◽  
Tertiary Hospital ◽  
Carbapenem Resistant

scholarly journals Molecular Characterization of Carbapenem-Resistant Klebsiella pneumoniae Species Isolated From a Tertiary Hospital, Ankara, Turkey

2017 ◽  
Vol 10 (10) ◽  
Author(s):  
Nevreste Celikbilek ◽  
Ozlem Unaldi ◽  
Fisun Kirca ◽  
Aysegul Gozalan ◽  
Ziya C Acikgoz ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Characterization ◽  
Tertiary Hospital ◽  
Carbapenem Resistant

scholarly journals Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Meritxell Cubero ◽  
Guillermo Cuervo ◽  
M. Ángeles Dominguez ◽  
Fe Tubau ◽  
Sara Martí ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Tertiary Hospital ◽  
Carbapenem Resistant

scholarly journals Prediction of Prognosis in Adult Patients With Carbapenem-Resistant Klebsiella pneumoniae Infection

2022 ◽  
Vol 11 ◽  
Author(s):  
Jihui Chen ◽  
Yu Yang ◽  
Huimin Yao ◽  
Shuhong Bu ◽  
Lixia Li ◽  
...  
Keyword(s):  
High Risk ◽  
Klebsiella Pneumoniae ◽  
Treatment Effectiveness ◽  
Risk Group ◽  
Clinical Information ◽  
Tertiary Hospital ◽  
High Risk Group ◽  
Adult Patients ◽  
Carbapenem Resistant ◽  
Prediction Of Prognosis

ObjectiveCarbapenem-resistant Klebsiella pneumoniae (CRKP) infections are associated with poor patient outcomes. We aimed to analyze the clinical information of adult patients with CRKP infection in order to establish a nomogram for mortality risk as well as to determine the treatment effectiveness of different antimicrobial regimens.MethodsAdult patients diagnosed with CRKP infection in a tertiary hospital in Shanghai between September 2019 and March 2021 were included. The clinical characteristics and clinical outcomes of these patients were analyzed.ResultsA total of 199 cases of CRKP infection were examined. Five factors, namely age ≥65 years, respiratory failure, Sequential Organ Failure Assessment score, serum procalcitonin ≥5 ng/mL, and appropriate treatments in 3 days, were found to be associated with 30-day mortality. Upon incorporating these factors, the nomogram achieved good concordance indexes of 0.85 (95% confidence interval [CI]: 0.80–0.90) and well-fitted calibration curves. Receiver-operating characteristic curves for 7-, 15-, and 30-day survival had areas under the curve of 0.90, 0.87, and 0.88, respectively. Three-drug combination therapy was observed to be associated with lower mortality in the high-risk group (adjusted hazard ratio = 0.24, 95% CI: 0.06–0.99) but not in the low-risk group. Ceftazidime–avibactam, fosfomycin, and amikacin were effective against infections caused by CRKP. Tigecycline improved the treatment efficiency in 7 days, but a trend toward increased mortality was seen (HR, 1.69; 95% CI: 0.98–2.94; P = 0.061).ConclusionThe antimicrobial regimen efficacy data and the predictive nomogram established in this study can help clinicians in identifying high-risk adult patients with CRKP infection, improving the therapeutic effect, and reducing mortality.

CP-108 Infections caused by carbapenem-resistant klebsiella pneumoniae in a tertiary hospital

2015 ◽  
Vol 22 (Suppl 1) ◽  
pp. A43.3-A44
Author(s):  
I Viguera-Guerra ◽  
F Franco-García ◽  
MD Aumente
Keyword(s):  
Klebsiella Pneumoniae ◽  
Tertiary Hospital ◽  
Carbapenem Resistant

scholarly journals Isolation and characterization of a sequence type 25 carbapenem-resistant hypervirulent Klebsiella pneumoniae from the mid-south region of China

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jun Li ◽  
Zi-Yan Huang ◽  
Ting Yu ◽  
Xiao-Yan Tao ◽  
Yong-Mei Hu ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Capsular Polysaccharide ◽  
Control Strategies ◽  
Virulence Gene ◽  
Sequence Type ◽  
Pfge Typing ◽  
Main Cluster ◽  
Carbapenem Resistant ◽  
Isolation And Characterization

Abstract Background The molecular characterization of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) isolates is not well studied. Our goal was to investigate the molecular epidemiology of CR-hvKP strains that were isolated from a Chinese hospital. Results All clinical carbapenem-resistant K. pneumoniae (CR-KP) isolates were collected and identified from patient samples between 2014 and 2017 from a Chinese hospital. The samples were subjected to screening for CR-hvKP by string test and the detection of the aerobactin gene. CR-hvKP isolates were further confirmed through neutrophil phagocytosis and a mice lethality assay. The CR-hvKP isolates were investigated for their capsular genotyping, virulence gene profiles, and the expression of carbapenemase genes by PCR and DNA sequencing. Multilocus sequence type (MLST) and pulsed-field gel electrophoresis (PFGE) were performed to exclude the homology of these isolates. Twenty strains were identified as CR-hvKP. These strains were resistant to imipenem and several other antibiotics, however, most were susceptible to amikacin. Notably, two isolates were not susceptible to tigecycline. Capsular polysaccharide synthesis genotyping revealed that 17 of the 20 CR-hvKP strains belonged to the K2 serotype, while the others belonged to serotypes other than K1, K2, K5, K20, and K57. The strains were found to be positive for 10 types of virulence genes and a variety of these genes coexisted in the same strain. Two carbapenemase genes were identified: blaKPC-2 (13/20) and blaNDM-1 (1/20). PFGE typing revealed eight clusters comprising isolates that belonged to MLST types ST25, ST11 and ST375, respectively. PFGE cluster A was identified as the main cluster, which included 11 isolates that belong to ST25 and mainly from ICU department. Conclusions Our findings suggest that hospital-acquired infections may contribute in part to the CR-hvKP strains identified in this study. It also suggests that ST25 CR-hvKP strain has a clonal distribution in our hospital. Therefore, effective surveillance and strict infection control strategies should be implemented to prevent outbreak by CR-hvKP strains in hospitals setting.

scholarly journals Molecular characterization of Carbapenem resistant Escherichia coli recovered from a tertiary hospital in Lebanon

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203323 ◽  
Author(s):  
Christel Dagher ◽  
Tamara Salloum ◽  
Sahar Alousi ◽  
Harout Arabaghian ◽  
George F. Araj ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Molecular Characterization ◽  
Tertiary Hospital ◽  
Carbapenem Resistant
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