scholarly journals Familial risk and heritability of intellectual disability: a population‐based cohort study in Sweden

2021 ◽  
Author(s):  
Paul Lichtenstein ◽  
Magnus Tideman ◽  
Patrick F. Sullivan ◽  
Eva Serlachius ◽  
Henrik Larsson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intellectual Disability ◽  
Familial Risk ◽  
Population Based

scholarly journals Cancer risk in individuals with intellectual disability in Sweden: A population-based cohort study

PLoS Medicine ◽  
2021 ◽  
Vol 18 (10) ◽  
pp. e1003840
Author(s):  
Qianwei Liu ◽  
Hans-Olov Adami ◽  
Abraham Reichenberg ◽  
Alexander Kolevzon ◽  
Fang Fang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intellectual Disability ◽  
Cancer Risk ◽  
Reference Group ◽  
Population Based ◽  
Sibling Comparison ◽  
Increased Risk ◽  
Specific Cancer ◽  
Cancer Types ◽  
Risk Of Cancer

Background A knowledge gap exists about the risk of cancer in individuals with intellectual disability (ID). The primary aim of this study was to estimate the cancer risk among individuals with ID compared to individuals without ID. Methods and findings We conducted a population-based cohort study of all children live-born in Sweden between 1974 and 2013 and whose mothers were born in a Nordic country. All individuals were followed from birth until cancer diagnosis, emigration, death, or 31 December 2016 (up to age 43 years), whichever came first. Incident cancers were identified from the Swedish Cancer Register. We fitted Cox regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) as measures of cancer risk in relation to ID after adjusting for several potential confounders. We analyzed ID by severity, as well as idiopathic ID and syndromic ID separately. We performed a sibling comparison to investigate familial confounding. The study cohort included a total of 3,531,305 individuals, including 27,956 (0.8%) individuals diagnosed with ID. Compared with the reference group (individuals without ID and without a full sibling with ID), individuals with ID were in general more likely to be male. The median follow-up time was 8.9 and 23.0 years for individuals with ID and individuals without ID, respectively. A total of 188 cancer cases were identified among individuals with ID (incidence rate [IR], 62 per 1,000 person-years), and 24,960 among individuals in the reference group (IR, 31 per 1,000 person-years). A statistically significantly increased risk was observed for any cancer (HR 1.57, 95% CI 1.35–1.82; P < 0.001), as well as for several cancer types, including cancers of the esophagus (HR 28.4, 95% CI 6.2–130.6; P < 0.001), stomach (HR 6.1, 95% CI 1.5–24.9; P = 0.013), small intestine (HR 12.0, 95% CI 2.9–50.1; P < 0.001), colon (HR 2.0, 95% CI 1.0–4.1; P = 0.045), pancreas (HR 6.0, 95% CI 1.5–24.8; P = 0.013), uterus (HR 11.7, 95% CI 1.5–90.7; P = 0.019), kidney (HR 4.4, 95% CI 2.0–9.8; P < 0.001), central nervous system (HR 2.7, 95% CI 2.0–3.7; P < 0.001), and other or unspecified sites (HR 4.8, 95% CI 1.8–12.9; P = 0.002), as well as acute lymphoid leukemia (HR 2.4, 95% CI 1.3–4.4; P = 0.003) and acute myeloid leukemia (HR 3.0, 95% CI 1.4–6.4; P = 0.004). Cancer risk was not modified by ID severity or sex but was higher for syndromic ID. The sibling comparison showed little support for familial confounding. The main study limitations were the limited statistical power for the analyses of specific cancer types, and the potential for underestimation of the studied associations (e.g., due to potential underdetection or delayed diagnosis of cancer among individuals with ID). Conclusions In this study, we found that individuals with ID showed an increased risk of any cancer, as well as of several specific cancer types. These findings suggest that extended surveillance and early intervention for cancer among individuals with ID are warranted.

scholarly journals Hospitalisation rates for children with intellectual disability or autism born in Western Australia 1983–1999: a population-based cohort study

BMJ Open ◽  
2013 ◽  
Vol 3 (2) ◽  
pp. e002356 ◽  
Author(s):  
Ami Bebbington ◽  
Emma Glasson ◽  
Jenny Bourke ◽  
Nicholas de Klerk ◽  
Helen Leonard
Keyword(s):  
Cohort Study ◽  
Intellectual Disability ◽  
Western Australia ◽  
Population Based ◽  
Children With Intellectual Disability

scholarly journals The effect of neonatal hypothyroidism and low family income on intellectual disability: A population-based cohort study

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0205955 ◽  
Author(s):  
Jin Young Nam ◽  
Young Choi ◽  
Mo Kyung Jung ◽  
Jaeyong Shin ◽  
Kyoung Hee Cho ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intellectual Disability ◽  
Family Income ◽  
Population Based ◽  
Neonatal Hypothyroidism

scholarly journals Mental illness, challenging behaviour, and psychotropic drug prescribing in people with intellectual disability: UK population based cohort study

BMJ ◽  
2015 ◽  
pp. h4326 ◽  
Author(s):  
Rory Sheehan ◽  
Angela Hassiotis ◽  
Kate Walters ◽  
David Osborn ◽  
André Strydom ◽  
...  
Keyword(s):  
Mental Illness ◽  
Cohort Study ◽  
Intellectual Disability ◽  
Psychotropic Drug ◽  
Population Based ◽  
Challenging Behaviour ◽  
Drug Prescribing

Familial Risk of Vitiligo among First-Degree Relatives and Spouses: A Population-Based Cohort Study in Korea

2020 ◽  
Author(s):  
Hyun Jung Kim ◽  
Hyeong Sik Ahn ◽  
Sayada Zartasha Kazmi ◽  
Taeuk Kang ◽  
Hei Sung Kim ◽  
...  
Keyword(s):  
Cohort Study ◽  
Familial Risk ◽  
Population Based ◽  
First Degree Relatives

Familial Risk of Inflammatory Bowel Disease: A Population-Based Cohort Study in South Korea

2020 ◽  
Author(s):  
Hyun Jung Kim ◽  
Shailja C. Shah ◽  
Hoo Jae Hann ◽  
Sayada Zartasha Kazmi ◽  
Taeuk Kang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
South Korea ◽  
Bowel Disease ◽  
Familial Risk ◽  
Population Based ◽  
Inflammatory Bowel

scholarly journals Familial risk of oral clefts by morphological type and severity: population based cohort study of first degree relatives

BMJ ◽  
2008 ◽  
Vol 336 (7641) ◽  
pp. 432-434 ◽  
Author(s):  
Åse Sivertsen ◽  
Allen J Wilcox ◽  
Rolv Skjærven ◽  
Hallvard Andreas Vindenes ◽  
Frank Åbyholm ◽  
...  
Keyword(s):  
Cohort Study ◽  
Familial Risk ◽  
Morphological Type ◽  
Population Based ◽  
Oral Clefts ◽  
First Degree Relatives
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