Analysis of the clinical characteristics of lamotrigine‐induced haemophagocytic lymphohistiocytosis

2022 ◽  
Author(s):  
Chunjiang Wang ◽  
Zhiqiang Fan ◽  
Yang He ◽  
Weijin Fang ◽  
Wei Sun ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Haemophagocytic Lymphohistiocytosis

scholarly journals Clinical characteristics and disease course in children with haemophagocytic lymphohistiocytosis treated at the University children’s hospital in Belgrade

2012 ◽  
Vol 140 (3-4) ◽  
pp. 191-197 ◽  
Author(s):  
Lidija Krivokapic-Dokmanovic ◽  
Nada Krstovski ◽  
Srdja Jankovic ◽  
Jelena Lazic ◽  
Nedeljko Radlovic ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Haematopoietic Stem Cell ◽  
Lymphocyte Function ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Cytotoxic Lymphocyte ◽  
Barr Virus ◽  
Genes Encoding ◽  
Syntaxin 11 ◽  
Barr Virus Infection ◽  
The University

Introduction. Haemophagocytic lymphohistiocytosis (HLH) is a disorder characterised by long-standing fever, splenomegaly and bicytopoenia or pancytopoenia. Lymphadenopathy, jaundice and neurological symptoms may also occur. HLH may ensue in various forms of innate or acquired immunodeficiency with impaired cytotoxic lymphocyte function resulting in excessive macrophage activation. Objective. To describe and analyse clinical characteristics of patients treated for HLH at the University Children?s Hospital of Belgrade from August 2000 to August 2010. Methods. Retrospective analysis of medical records. Results. Diagnosis of HLH was established in 13 children (five boys and eight girls) aged from one month to 14 years. In six children HLH was secondary (to visceral leishmaniasis in two, Ebstein-Barr virus infection in one, Langerhans? cell histiocytosis in one and systemic juvenile rheumatoid arthritis in two). Of the remaining seven patients, genes for perforin and syntaxin 11 were examined in two and no mutations were found. Of the remaining seven patients, genes encoding perforin and syntaxin 11 were analyzed in two, but no mutations were found. All children had fever, splenomegaly, cytopoenias, hyperferritinaemia and hypertriglyceridaemia, but haemophagocytosis was seen in only six (46.1%). Six children were cured (four with secondary HLH and two with primary HLH). Two children are undergoing treatment, while five succumbed (three before treatment could be administered and two due to complications). In four of the six cured children, HLH arose in the first year of life. Cure rate in those who underwent haematopoietic stem cell trans- plantation was 2/3. Conclusion. Results underscore the importance of timely diagnosis and treatment of HLH, warranting that in all children with fever, splenomegaly and/or cytopoenias, with or without haemophagocytosis, HLH be actively sought.

Agreement between IBD patients' self-report and chart reviews on key clinical characteristics

2001 ◽  
Vol 120 (5) ◽  
pp. A234-A234
Author(s):  
R HILSDEN ◽  
M VERHOEF ◽  
A BEST ◽  
R ENNS
Keyword(s):  
Clinical Characteristics ◽  
Self Report

Tu1788 CLINICAL CHARACTERISTICS AND TREATMENT DIFFERENCES BETWEEN YOUNGER AND OLDER ONSET MICROSCOPIC COLITIS: A MULTICENTER RETROSPECTIVE COHORT STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1161
Author(s):  
Amrit K. Kamboj ◽  
Amandeep Gujral ◽  
Elida Voth ◽  
Daniel Penrice ◽  
Jessica McGoldrick ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Microscopic Colitis

103: Incidence and Clinical Characteristics of NIH Type III Prostatitis in a Managed Care Population

2005 ◽  
Vol 173 (4S) ◽  
pp. 28-28 ◽  
Author(s):  
J. Quentin Clemens ◽  
Richard T. Meenan ◽  
Maureen C. O'Keeffe Rosetti ◽  
Sara Y. Gao ◽  
Elizabeth A. Calhoun
Keyword(s):  
Managed Care ◽  
Clinical Characteristics ◽  
Type Iii

100: Comparison of Demographic and Clinical Characteristics of the Malaysian and National Institutes of Health Chronic Prostatitis Cohort

2006 ◽  
Vol 175 (4S) ◽  
pp. 32-33
Author(s):  
Shaun W.H. Lee ◽  
Phaik Yeong Cheah ◽  
Men Long Liong ◽  
Kah Hay Yuen ◽  
Anthony J. Schaeffer ◽  
...  
Keyword(s):  
Chronic Prostatitis ◽  
Clinical Characteristics ◽  
National Institutes Of Health

Abstract #535: Clinical Characteristics of Primary Hyperparathyroidism Among Different Age Groups

2017 ◽  
Vol 23 ◽  
pp. 118-119
Author(s):  
Beatrice Wong ◽  
Anjana Divakaran ◽  
Kenneth Sluis ◽  
Hyon Kim ◽  
Vanessa Narwani ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Clinical Characteristics ◽  
Age Groups

Abstract #295 Epidemiologic and Clinical Characteristics of Diabetic Foot Ulcers – Report From South West Nigeria

2019 ◽  
Vol 25 ◽  
pp. 121-122
Author(s):  
Olufunmilayo Adeleye ◽  
Ejiofor Ugwu ◽  
Anthonia Ogbera ◽  
Akinola Dada ◽  
Ibrahim Gezawa ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Clinical Characteristics ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
South West

Acute encephalopathy as a primary manifestation of haemophagocytic lymphohistiocytosis

2001 ◽  
Vol 43 (08) ◽  
pp. 555 ◽  
Author(s):  
Matthias Kieslich ◽  
Marilena Vecchi ◽  
Pablo Hernaiz Driever ◽  
Anna Maria Laverda ◽  
Dirk Schwabe ◽  
...  
Keyword(s):  
Acute Encephalopathy ◽  
Haemophagocytic Lymphohistiocytosis
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