Abstract #535: Clinical Characteristics of Primary Hyperparathyroidism Among Different Age Groups

Abstract Background The Philippines has been one of the most affected COVID-19 countries in the Western Pacific region, but there are limited data on COVID-19-related mortality and associated factors from this setting. We aimed to describe the epidemiological and clinical characteristics and associations with mortality among COVID-19-confirmed individuals admitted to an infectious diseases referral hospital in Metro Manila. Main text This was a single-centre retrospective analysis including the first 500 laboratory-confirmed COVID-19 individuals admitted to San Lazaro Hospital, Metro Manila, Philippines, from January to October 2020. We extracted clinical data and examined epidemiological and clinical characteristics and factors associated with in-hospital mortality. Of the 500 individuals, 133 (26.6%) were healthcare workers (HCW) and 367 (73.4%) were non-HCW, with HCW more likely presenting with milder symptoms. Non-HCW admissions were more likely to have at least one underlying disease (51.6% vs. 40.0%; p = 0.002), with hypertension (35.4%), diabetes (17.4%), and tuberculosis (8.2%) being the most common. Sixty-one (12.2%) died, comprising 1 HCW and 60 non-HCW (0.7% vs. 16.3%; p < 0.001). Among the non-HCW, no death occurred for the 0–10 years age group, but deaths were recorded across all other age groups. Compared to those who recovered, individuals who died were more likely to be older (p < 0.001), male (p = 0.015), report difficulty of breathing (p < 0.001), be HIV positive (p = 0.008), be intubated (p < 0.001), categorised as severe or critical (p < 0.001), have a shorter mean hospital stay (p < 0.001), or have an additional diagnosis of pneumonia (p < 0.001) or ARDS (p < 0.001). Conclusion Our analysis reflected significant differences in characteristics, symptomatology, and outcomes between healthcare and non-healthcare workers. Despite the unique mix of cohorts, our results support the country’s national guideline on COVID-19 vaccination which prioritises healthcare workers, the elderly, and people with comorbidities and immunodeficiency states.

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Clinical Characteristics, Complications, and Reasons for Readmission following Lingual Tonsillectomy

Otolaryngology ◽

10.1177/0194599819827820 ◽

2019 ◽

Vol 160 (4) ◽

pp. 619-621 ◽

Cited By ~ 1

Author(s):

Catherine Merna ◽

Harrison W. Lin ◽

Neil Bhattacharyya

Keyword(s):

Obstructive Sleep Apnea ◽

Clinical Characteristics ◽

Age Groups ◽

Complication Rates ◽

Indications For Surgery ◽

Lingual Tonsil ◽

Obstructive Sleep ◽

Lingual Tonsillectomy ◽

The Common ◽

Indications And Complications

This brief communication regards the indications and complications for and rates of readmission following lingual tonsillectomy. The National Readmissions Database (NRD) 2013-2014 was queried for all cases of lingual tonsillectomy occurring from 2013 to 2014. Among 602 lingual tonsillectomies (mean age 36.5 years, 58.2% male), the common indications for surgery were obstructive sleep apnea (58.7%), lingual tonsil hypertrophy/infection (18.8%), and neoplasia (15.9%). Overall, 49 (8.2%) of the cases were readmitted (95% confidence interval, 4.8%-13.5%), with an average readmission duration of 3.0 days and average readmission cost of $25.4K. The most common diagnoses at readmission were bleeding (1.9% of all lingual tonsillectomy cases); dysphagia (1.7%); fever, nausea, vomiting, or diarrhea (1.6%); acute pain (1.6%); and airway obstruction (1.4%). There were no mortalities during primary or subsequent admissions. Lingual tonsillectomy across age groups is relatively free of adverse events, with overall readmission and complication rates similar to those of palatine tonsillectomy.

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1101. Comparison of Clinical Characteristics and Demographics of GII.4 vs. Other GII Noroviruses Associated With Sporadic Acute Gastroenteritis in Children in Nashville, TN, 2012–2015

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy210.936 ◽

2018 ◽

Vol 5 (suppl_1) ◽

pp. S330-S330

Author(s):

Einas Batarseh ◽

Lubna Hamdan ◽

Bhinnata Piya ◽

Laura Stewart ◽

James D Chappell ◽

...

Keyword(s):

Acute Gastroenteritis ◽

Clinical Characteristics ◽

Age Groups ◽

Severe Illness ◽

Genotype Distribution ◽

Research Support ◽

Inpatient Settings ◽

Prevalent Strain ◽

Stool Specimens ◽

Sporadic Acute Gastroenteritis

Abstract Background Norovirus is a leading cause of acute gastroenteritis (AGE) in all age groups. Although at least 28 different genotypes infecting humans have been reported, most outbreaks over the last 15 years have been caused by genogroup II (GII) viruses, of which GII.4 viruses have caused more than 50%. Since clinical differences between different genotypes are poorly understood, we sought to compare clinical characteristics in children infected with GII.4 and non-GII.4 viruses. Methods Children between 15 days and 17 years who presented with AGE defined as diarrhea (≥3 loose stools in a 24 hour period) or vomiting (≥1 episodes in a 24 hour period) within 10 days duration were recruited in outpatient, emergency, and inpatient settings in Nashville, TN, during 2012–2015. Stool specimens were tested by RT-qPCR for GI and GII norovirus. Norovirus-positive specimens were genotyped by sequencing of a partial region of the capsid gene. In this study, we excluded children infected with GI, mixed GI/GII and non-typeable GII viruses. Results Of 3,705 AGE subjects enrolled, 2,892 (78%) specimens were collected, 637 (22%) tested norovirus-positive (567 [89%] GII, 62 [10%] GI, and 8 [1%] mixed GI/GII). Of the 567 GII viruses, 461 (81%) were able to be genotyped and of those 238/461 (51.6%) were typed as GII.4 and 223/461 (48.3%) were typed as other GII genotypes (non-GII.4, primarily GII.3 [65/ 461, 14.1%], GII.6 [48/461, 10.4%] and GII.7 [36/461, 7.8%]). Over three AGE seasons, GII.4 represented 64/117 (54%), 79/178 (44%), and 71/166 (57%), of the GII infections, respectively. Compared with non-GII.4 subjects, GII.4 subjects were more likely to be younger (15.5 vs. 21.3 months, P < 0.01), and less likely to attend daycare (23% vs. 39%, P < 0.01). GII.4 subjects also were more likely to present with diarrhea (75% vs. 57%, P < 0.01) and had higher median modified Vesikari score (7 vs. 6, P < 0.01). Conclusion Children infected with GII.4 viruses were younger, less likely to attend child care, more likely to present with diarrhea, and had a more severe illness compared with those with non-GII.4 infections. These data provide important information on the genotype distribution of norovirus in children with AGE in Tennessee and highlight GII.4 as the most prevalent strain. Disclosures N. Halasa, sanofi pasteur: Investigator, Research support. GSK: Consultant, Consulting fee. Moderna: Consultant, Consulting fee.

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The Clinical Characteristics of ADHD Diagnosed in Adolescents in Comparison With Younger Children

Journal of Attention Disorders ◽

10.1177/1087054717696768 ◽

2017 ◽

Vol 24 (8) ◽

pp. 1125-1131 ◽

Cited By ~ 1

Author(s):

Muhammad Mahajnah ◽

Rajech Sharkia ◽

Nadeem Shorbaji ◽

Nathanel Zelnik

Keyword(s):

Clinical Characteristics ◽

Rebound Effect ◽

Age Groups ◽

Learning Disorders ◽

Newly Diagnosed ◽

Group I ◽

Age Dependent ◽

Group Ii ◽

Long Acting ◽

Biological Nature

Objective: The aim of this study is to identify the clinical characteristics in adolescents newly diagnosed with ADHD. Method: Data of patients aged 7 to 17 years diagnosed with ADHD were collected and analyzed. The patients were divided into adolescents aged 13 to 17 years (Group I) and children aged 7 to 12 years (Group II): 592 males and 231 females. Group I consists of 450 participants, and Group II consists of 373 participants. Results: Adolescents were predominantly inattentive (63.8%); most of Group II patients had combined or hyperactive ADHD (70.8%). Learning disorders were more common in adolescents (51.2% vs. 39.7%) and treated mainly with long-acting methylphenidate (MPH), and Group II patients were treated mainly with short- and medium-acting MPH. Newly diagnosed adolescents were less likely to exhibit behavioral comorbidities. Headache and insomnia were reported more in adolescents, and stimulant rebound effect was more in younger children. Conclusion: Although the biological nature of ADHD is similar in both age groups, the primary symptomatology and associated comorbidities are prone to age-dependent changes.

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Novel somatic MEN1 gene alterations in sporadic primary hyperparathyroidism and correlation with clinical characteristics

Journal of Endocrinological Investigation ◽

10.1007/bf03345303 ◽

2004 ◽

Vol 27 (11) ◽

pp. 1015-1021 ◽

Cited By ~ 19

Author(s):

D. Scarpelli ◽

L. D’Aloiso ◽

F. Arturi ◽

A. Scillitani ◽

I. Presta ◽

...

Keyword(s):

Primary Hyperparathyroidism ◽

Clinical Characteristics ◽

Men1 Gene ◽

Sporadic Primary Hyperparathyroidism ◽

Gene Alterations

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Difference of clinical characteristics of inflammatory bowel disease in different age groups of patients: A single-center analysis

World Chinese Journal of Digestology ◽

10.11569/wcjd.v24.i4.623 ◽

2016 ◽

Vol 24 (4) ◽

pp. 623

Author(s):

Ai-Qin Liu

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Clinical Characteristics ◽

Age Groups ◽

Single Center ◽

Inflammatory Bowel

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Clinical Presentation of Primary Hyperparathyroidism in Older Adults

Journal of the Endocrine Society ◽

10.1210/js.2019-00316 ◽

2019 ◽

Vol 3 (12) ◽

pp. 2305-2312 ◽

Cited By ~ 2

Author(s):

Elena Castellano ◽

Roberto Attanasio ◽

Alberto Boriano ◽

Giorgio Borretta

Keyword(s):

Older Adults ◽

Primary Hyperparathyroidism ◽

Older Patients ◽

Clinical Presentation ◽

Renal Involvement ◽

Age Groups ◽

Urinary Calcium ◽

Interquartile Range ◽

Younger Patients ◽

Vitamin D Levels

Abstract Background The clinical presentation of primary hyperparathyroidism (PHPT) has changed greatly during the past few decades. Our aim was to evaluate whether the clinical presentation at diagnosis differed according to age. Methods We evaluated retrospectively a monocentric series of 462 consecutive patients with PHPT, dividing them according to a cutoff of 65 years of age. Results No differences were found in the mean serum PTH, calcium, or vitamin D levels. In older patients (n = 212; 45.9%), the urinary calcium levels were significantly lower (median, 205 mg/24 hour; interquartile range, 220 mg/24 hour) compared with those in younger patients (median, 308 mg/24 hour; interquartile range, 233 mg/24 hour). In addition, renal involvement was significantly less frequent (25% vs 49.2%), and bone involvement significantly more frequent (58% vs 44%) in older patients compared with younger patients. The clinical presentation was significantly different between the two age groups, with a lower frequency of symptomatic forms and a greater frequency of asymptomatic forms not meeting surgical criteria in the older patients (44.4% vs 57.2% and 18.4% vs 5.6%, respectively). Osteoporosis was significantly more frequent in the older adults than in their younger counterparts. The most affected bone site was the forearm in older adults and the lumbar spine in younger ones (50.3% and 50.5%, respectively). Conclusion The clinical presentation of PHPT differs according to age, and this difference can affect the selection of management modalities.

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Aneurysmal subarachnoid hemorrhage in young adults: a comparison between patients in the third and fourth decades of life

Journal of Neurosurgery ◽

10.3171/jns.2003.99.2.0276 ◽

2003 ◽

Vol 99 (2) ◽

pp. 276-279 ◽

Cited By ~ 13

Author(s):

Tetsuyoshi Horiuchi ◽

Yuichiro Tanaka ◽

Kazuhiro Hongo ◽

Shigeaki Kobayashi

Keyword(s):

Young Adults ◽

Clinical Characteristics ◽

Aneurysmal Subarachnoid Hemorrhage ◽

Age Groups ◽

Cerebral Aneurysms ◽

Content Type ◽

The Third ◽

Fourth Decade ◽

Fine Print ◽

Two Age Groups

Object. Aneurysmal subarachnoid hemorrhage rarely occurs in young adults. The aim of this work was to clarify the clinical characteristics of ruptured aneurysms in young adults in the third and fourth decades of life and to compare these two age groups. Methods. The authors retrospectively investigated 2493 patients who underwent surgical repair for ruptured cerebral aneurysms during a 14-year period (1988–2001). There were 25 patients (1%) in the third decade of life and 106 patients (4.3%) in the fourth decade. In general, favorable outcome was achieved in both groups. There were significant differences in the sizes and locations of aneurysms between the two age groups. Among patients in the fourth decade of life, the aneurysm was large and was located more often on the anterior cerebral artery. Conclusions. In this study the authors summarize the clinical characteristics of a large series of 131 young adult patients with ruptured cerebral aneurysms. Congenital factors as well as hemodynamic stress may contribute to differences in aneurysm size and location between the two age groups.

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