Antcin K inhibits VEGF‐dependent angiogenesis in human rheumatoid arthritis synovial fibroblasts

2021 ◽  
Author(s):  
David Achudhan ◽  
Shan‐Chi Liu ◽  
Yen‐You Lin ◽  
Hsiang‐Ping Lee ◽  
Shih‐Wei Wang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fibroblasts ◽  
Human Rheumatoid Arthritis

scholarly journals Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways

2020 ◽  
Vol 31 (1) ◽  
pp. 740-750 ◽  
Author(s):  
Hsiang-Ping Lee ◽  
Yang-Chang Wu ◽  
Bo-Cheng Chen ◽  
Shan-Chi Liu ◽  
Te-Mao Li ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fibroblasts ◽  
Signalling Pathways ◽  
Human Rheumatoid Arthritis

Interleukin-1β induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: Involvement of ERK, JNK, AP-1, and NF-κB

2010 ◽  
Vol 224 (2) ◽  
pp. 516-526 ◽  
Author(s):  
Chuen-Mao Yang ◽  
Shue-Fen Luo ◽  
Hsi-Lung Hsieh ◽  
Pei-Ling Chi ◽  
Chih-Chung Lin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Leukocyte Adhesion ◽  
Synovial Fibroblasts ◽  
Interleukin 1Β ◽  
Human Rheumatoid Arthritis

Enhancement of placenta growth factor expression by oncostatin M in human rheumatoid arthritis synovial fibroblasts

2013 ◽  
Vol 228 (5) ◽  
pp. 983-990 ◽  
Author(s):  
Huang-Ju Tu ◽  
Tzu-Hung Lin ◽  
Yung-Cheng Chiu ◽  
Chih-Hsin Tang ◽  
Rong-Sen Yang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Growth Factor ◽  
Synovial Fibroblasts ◽  
Oncostatin M ◽  
Human Rheumatoid Arthritis ◽  
Placenta Growth Factor ◽  
Factor Expression ◽  
Growth Factor Expression

scholarly journals Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153142 ◽  
Author(s):  
Tatsuo Watanabe ◽  
Nobunori Takahashi ◽  
Shinya Hirabara ◽  
Naoki Ishiguro ◽  
Toshihisa Kojima
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fibroblasts ◽  
Human Rheumatoid Arthritis ◽  
Rankl Expression

Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts

2017 ◽  
Vol 132 ◽  
pp. 77-91 ◽  
Author(s):  
Chuen-Mao Yang ◽  
Yu-Wen Chen ◽  
Pei-Ling Chi ◽  
Chih-Chung Lin ◽  
Li-Der Hsiao
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fibroblasts ◽  
Human Rheumatoid Arthritis ◽  
Cox 2

scholarly journals Epigallocatechin‐3‐gallate (EGCG) inhibits RANTES/CCL5 induced MMP‐1 and MMP‐13 expression in human rheumatoid arthritis synovial fibroblasts

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Solomon Agere ◽  
Nahid Akhtar ◽  
Sharayah Riegsecker ◽  
Salahuddin Ahmed
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fibroblasts ◽  
Human Rheumatoid Arthritis

05.05 Systematic profiling of mouse synovial fibroblasts during tnf-driven arthritogenesis and alignments to human rheumatoid arthritis

2017 ◽  
Author(s):  
Evangelos Ntougkos ◽  
Panagiotis Chouvardas ◽  
Fani Roumelioti ◽  
Caroline Ospelt ◽  
Mojka Frank-Bertoncelj ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fibroblasts ◽  
Human Rheumatoid Arthritis

scholarly journals Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway

2021 ◽  
Vol 22 (22) ◽  
pp. 12580
Author(s):  
Paul M. Panipinto ◽  
Anil K. Singh ◽  
Farheen S. Shaikh ◽  
Ruby J. Siegel ◽  
Mukesh Chourasia ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Specific Activity ◽  
Gouty Arthritis ◽  
Synovial Fibroblasts ◽  
Janus Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Great Promise ◽  
Central Position ◽  
Human Rheumatoid Arthritis ◽  
Stat Pathway

TGF β-activated kinase 1 (TAK1) is an important participant in inflammatory pathogenesis for diseases such as rheumatoid arthritis (RA) and gouty arthritis. The central position it occupies between the mitogen activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways makes it an attractive therapeutic target. As this field has developed in recent years, several novel inhibitors have been presented as having specific activity that reduces the TAK1 function either covalently as in the case of 5Z-7-oxozeanol (5Z7O) or reversibly (NG-25). However, the mechanism through which takinib elicits its anti-inflammatory activity remains elusive. While this inhibitor shows great promise, a thorough analysis of its inhibitor function and its potential off-target effects is necessary before addressing its clinical potential or its use in inflammatory conditions. An analysis through Western blot showed an unexpected increase in IL-1β-induced TAK1 phosphorylation—a prerequisite for and indicator of its functional potential—by takinib while simultaneously demonstrating the inhibition of the JAK/STAT pathway in human rheumatoid arthritis synovial fibroblasts (RASFs) in vitro. In THP-1 monocyte-derived macrophages, takinib again led to the lipopolysaccharide-induced phosphorylation of TAK1 without a marked inhibition of the TAK1 downstream effectors, namely, of c-Jun N-terminal kinase (JNK), phospho-c-Jun, NF-κB phospho-p65 or phospho-IκBα. Taken together, these findings indicate that takinib inhibits inflammation in these cells by targeting multiple signaling pathways, most notably the JAK/STAT pathway in human RASFs.

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