Beneficial effects of dual vascular endothelial growth factor receptor/fibroblast growth factor receptor inhibitor brivanib alaninate in cirrhotic portal hypertensive rats

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Hypertensive Rats ◽

Beneficial Effects ◽

Brivanib Alaninate ◽

Receptor Inhibitor

Discovery of Brivanib Alaninate: A Dual Vascular Endothelial Growth Factor and Fibroblast Growth Factor Receptor Inhibitor

Kinase Inhibitor Drugs ◽

10.1002/9780470524961.ch6 ◽

2009 ◽

pp. 131-166

Author(s):

Rajeev S. Bhide ◽

Joseph Fargnoli

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Brivanib Alaninate ◽

Receptor Inhibitor

Discovery of Brivanib Alaninate ((S)-((R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215)

Journal of Medicinal Chemistry ◽

10.1021/jm7013309 ◽

2008 ◽

Vol 51 (6) ◽

pp. 1976-1980 ◽

Cited By ~ 96

Author(s):

Zhen-wei Cai ◽

Yongzheng Zhang ◽

Robert M. Borzilleri ◽

Ligang Qian ◽

Stephanie Barbosa ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Brivanib Alaninate ◽

Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models of Human Hepatocellular Carcinoma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-0509 ◽

2008 ◽

Vol 14 (19) ◽

pp. 6146-6153 ◽

Cited By ~ 163

Author(s):

Hung Huynh ◽

Van Chanh Ngo ◽

Joseph Fargnoli ◽

Mark Ayers ◽

Khee Chee Soo ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Dual Inhibitor ◽

Brivanib Alaninate ◽

Expression of Epidermal Growth Factor Receptor (EGF-R), Vascular Endothelial Growth Factor Receptor (VEGF-R) and Fibroblast Growth Factor Receptor (FGF-R) Systems in Porcine Oviduct and Endometrium during the Time of Implantation

Journal of Reproduction and Development ◽

10.1262/jrd.50.269 ◽

2004 ◽

Vol 50 (3) ◽

pp. 269-278 ◽

Cited By ~ 27

Author(s):

Karin WOLLENHAUPT ◽

Harald WELTER ◽

Ralf EINSPANIER ◽

Noboru MANABE ◽

Klaus-Peter BRÜSSOW

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Epidermal Growth ◽

Design, Synthesis, and Evaluation of Orally Active 4-(2,4-Difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm0501275 ◽

2005 ◽

Vol 48 (12) ◽

pp. 3991-4008 ◽

Cited By ~ 46

Author(s):

Robert M. Borzilleri ◽

Xiaoping Zheng ◽

Ligang Qian ◽

Christopher Ellis ◽

Zhen-wei Cai ◽

...

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Design Synthesis ◽

Orally Active

Contrast‑enhanced computed tomography combined with Chitosan‑Fe3O4 nanoparticles targeting fibroblast growth factor receptor and vascular endothelial growth factor receptor in the screening of early esophageal cancer

Experimental and Therapeutic Medicine ◽

10.3892/etm.2018.6087 ◽

2018 ◽

Author(s):

Juanjuan Gai ◽

Zhenli Gao ◽

Liqiang Song ◽

Yongyun Xu ◽

Weixin Liu ◽

...

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Early Esophageal Cancer ◽

Contrast Enhanced ◽

Enhanced Computed Tomography ◽

Contrast Enhanced Computed Tomography

MicroRNA-16 and MicroRNA-424 Regulate Cell-Autonomous Angiogenic Functions in Endothelial Cells via Targeting Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.111.236521 ◽

2011 ◽

Vol 31 (11) ◽

pp. 2595-2606 ◽

Cited By ~ 170

Author(s):

Aránzazu Chamorro-Jorganes ◽

Elisa Araldi ◽

Luiz O.F. Penalva ◽

Devraj Sandhu ◽

Carlos Fernández-Hernando ◽

...

Keyword(s):

Endothelial Cells ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor

Cancer Gene Therapy ◽

10.1038/sj.cgt.7700478 ◽

2002 ◽

Vol 9 (8) ◽

pp. 633-640 ◽

Cited By ~ 48

Author(s):

Tadashi Ogawa ◽

Koichi Takayama ◽

Nobuyuki Takakura ◽

Seigo Kitano ◽

Hikaru Ueno

Keyword(s):

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Soluble Receptors ◽

Inhibition Of Tumor Growth ◽

Fibroblast Growth Factor Receptor 1 (FGFR1), Partly Related to Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) and Microvessel Density, is an Independent Prognostic Factor for Non-Small Cell Lung Cancer

Medical Science Monitor ◽

10.12659/msm.899005 ◽

2017 ◽

Vol 23 ◽

pp. 247-257 ◽

Cited By ~ 9

Author(s):

Dan Pu ◽

Jiewei Liu ◽

Zhixi Li ◽

Jiang Zhu ◽

Mei Hou

Keyword(s):

Lung Cancer ◽

Growth Factor ◽

Growth Factor Receptor ◽

Small Cell ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Small Cell Lung ◽

Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases

Journal of Medicinal Chemistry ◽

10.1021/jm0500931 ◽

2005 ◽

Vol 48 (14) ◽

pp. 4628-4653 ◽

Cited By ~ 35

Author(s):

Andrew M. Thompson ◽

Amy M. Delaney ◽

James M. Hamby ◽

Mel C. Schroeder ◽

Teresa A. Spoon ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Fibroblast Growth ◽

Structure Activity ◽

Dual Inhibitors ◽