Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons

2021 ◽  
Author(s):  
Daniela Vallejo ◽  
Carolina B. Lindsay ◽  
Christian González‐Billault ◽  
Nibaldo C. Inestrosa
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Rho Gtpase ◽  
Gtpase Activity ◽  
Spine Dynamics

PINK1 Silencing Modifies Dendritic Spine Dynamics of Mouse Hippocampal Neurons

2019 ◽  
Vol 69 (4) ◽  
pp. 570-579 ◽  
Author(s):  
C. J. Hernández ◽  
C. Báez-Becerra ◽  
M. J. Contreras-Zárate ◽  
H. Arboleda ◽  
G. Arboleda
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Spine Dynamics

scholarly journals Early Effects of Aβ Oligomers on Dendritic Spine Dynamics and Arborization in Hippocampal Neurons

2020 ◽  
Vol 12 ◽  
Author(s):  
Carolina Ortiz-Sanz ◽  
Adhara Gaminde-Blasco ◽  
Jorge Valero ◽  
Lidia Bakota ◽  
Roland Brandt ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Aβ Oligomers ◽  
Early Effects ◽  
Spine Dynamics

The effect of kainic acid on hippocampal dendritic spine dynamics

2016 ◽  
Vol 26 ◽  
pp. S302
Author(s):  
T. Lortkipanidze ◽  
T. Bikashvili ◽  
M. Kiladze
Keyword(s):  
Kainic Acid ◽  
Dendritic Spine ◽  
Spine Dynamics

scholarly journals An in vitro reproduction of stress-induced memory defects: Effects of corticoids on dendritic spine dynamics

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shinichi Saito ◽  
Satoshi Kimura ◽  
Naoki Adachi ◽  
Tadahiro Numakawa ◽  
Akihiko Ogura ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Spine Dynamics

Ghrelin treatment leads to dendritic spine remodeling in hippocampal neurons and increases the expression of specific BDNF-mRNA species

2021 ◽  
Vol 179 ◽  
pp. 107409
Author(s):  
M.L. Perea Vega ◽  
M.S. Sanchez ◽  
G. Fernández ◽  
M.G. Paglini ◽  
M. Martin ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Bdnf Mrna ◽  
Mrna Species

scholarly journals Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells

Small GTPases ◽  
2017 ◽  
Vol 10 (3) ◽  
pp. 178-186 ◽  
Author(s):  
Joachim Goedhart ◽  
Jakobus van Unen
Keyword(s):  
Rho Gtpase ◽  
Living Cells ◽  
Gtpase Activity ◽  
Spatiotemporal Features ◽  
Rho Gef

scholarly journals Inactivation of Rho GTPases by Statins Attenuates Anthrax Lethal Toxin Activity

2008 ◽  
Vol 77 (1) ◽  
pp. 348-359 ◽  
Author(s):  
Aimee M. deCathelineau ◽  
Gary M. Bokoch
Keyword(s):  
Rho Gtpases ◽  
Rho Gtpase ◽  
Protective Antigen ◽  
Biological Effects ◽  
Lethal Factor ◽  
Lethal Toxin ◽  
Mitogen Activated Protein Kinase ◽  
Gtpase Activity ◽  
Anthrax Lethal Toxin ◽  
Reductase Inhibitors

ABSTRACT Anthrax lethal factor (LF), secreted by Bacillus anthracis, interacts with protective antigen to form a bipartite toxin (lethal toxin [LT]) that exerts pleiotropic biological effects resulting in subversion of the innate immune response. Although the mitogen-activated protein kinase kinases (MKKs) are the major intracellular protein targets of LF, the pathology induced by LT is not well understood. The statin family of HMG-coenzyme A reductase inhibitors have potent anti-inflammatory effects independent of their cholesterol-lowering properties, which have been attributed to modulation of Rho family GTPase activity. The Rho GTPases regulate vesicular trafficking, cytoskeletal dynamics, and cell survival and proliferation. We hypothesized that disruption of Rho GTPase function by statins might alter LT action. We show here that statins delay LT-induced death and MKK cleavage in RAW macrophages and that statin-mediated effects on LT action are attributable to disruption of Rho GTPases. The Rho GTPase-inactivating toxin, toxin B, did not significantly affect LT binding or internalization, suggesting that the Rho GTPases regulate trafficking and/or localization of LT once internalized. The use of drugs capable of inhibiting Rho GTPase activity, such as statins, may provide a means to attenuate intoxication during B. anthracis infection.

scholarly journals Low-dose Chemotherapeutic Agents Regulate Small Rho GTPase Activity in Dendritic Cells

2008 ◽  
Vol 31 (5) ◽  
pp. 491-499 ◽  
Author(s):  
Galina V. Shurin ◽  
Irina L. Tourkova ◽  
Michael R. Shurin
Keyword(s):  
Dendritic Cells ◽  
Low Dose ◽  
Rho Gtpase ◽  
Chemotherapeutic Agents ◽  
Gtpase Activity
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