Ghrelin treatment leads to dendritic spine remodeling in hippocampal neurons and increases the expression of specific BDNF-mRNA species

2021 ◽  
Vol 179 ◽  
pp. 107409
Author(s):  
M.L. Perea Vega ◽  
M.S. Sanchez ◽  
G. Fernández ◽  
M.G. Paglini ◽  
M. Martin ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Bdnf Mrna ◽  
Mrna Species

scholarly journals Deep Sequencing and High-Resolution Imaging Reveal Compartment-Specific Localization of Bdnf mRNA in Hippocampal Neurons

2013 ◽  
Vol 6 (306) ◽  
pp. rs16-rs16 ◽  
Author(s):  
T. J. Will ◽  
G. Tushev ◽  
L. Kochen ◽  
B. Nassim-Assir ◽  
I. J. Cajigas ◽  
...  
Keyword(s):  
High Resolution ◽  
Deep Sequencing ◽  
Hippocampal Neurons ◽  
High Resolution Imaging ◽  
Bdnf Mrna ◽  
Specific Localization ◽  
Resolution Imaging

scholarly journals TheGαoActivator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Valerie T. Ramírez ◽  
Eva Ramos-Fernández ◽  
Nibaldo C. Inestrosa
Keyword(s):  
Protein Kinase ◽  
Dendritic Spine ◽  
Hippocampal Neurons ◽  
Biological Effects ◽  
Critical Role ◽  
Head Width ◽  
Dependent Manner ◽  
Spine Density ◽  
Dendritic Spine Density

Mastoparan-7 (Mas-7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator ofPertussis toxin-(PTX-) sensitive G proteins. Mas-7 produces several biological effects in different cell types; however, little is known about how Mas-7 influences mature hippocampal neurons. We examined the specific role of Mas-7 in the development of dendritic spines, the sites of excitatory synaptic contact that are crucial for synaptic plasticity. We report here that exposure of hippocampal neurons to a low dose of Mas-7 increases dendritic spine density and spine head width in a time-dependent manner. Additionally, Mas-7 enhances postsynaptic density protein-95 (PSD-95) clustering in neurites and activatesGαosignaling, increasing the intracellular Ca2+concentration. To define the role of signaling intermediates, we measured the levels of phosphorylated protein kinase C (PKC), c-Jun N-terminal kinase (JNK), and calcium-calmodulin dependent protein kinase IIα(CaMKIIα) after Mas-7 treatment and determined that CaMKII activation is necessary for the Mas-7-dependent increase in dendritic spine density. Our results demonstrate a critical role forGαosubunit signaling in the regulation of synapse formation.

scholarly journals Suppressor of Cytokine Signalling 2 (SOCS2) Regulates Numbers of Mature Newborn Adult Hippocampal Neurons and Their Dendritic Spine Maturation

2016 ◽  
Vol 37 (5) ◽  
pp. 899-909 ◽  
Author(s):  
Harleen S. Basrai ◽  
Alisa Turbic ◽  
Kimberly J. Christie ◽  
Ann M. Turnley
Keyword(s):  
Dendritic Spine ◽  
Hippocampal Neurons
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