scholarly journals The G protein‐coupled oestrogen receptor, GPER1, mediates direct anti‐inflammatory effects of oestrogens in human cholinergic neurones from the nucleus basalis of Meynert

2020 ◽  
Vol 32 (3) ◽  
Author(s):  
Erica Sarchielli ◽  
Giulia Guarnieri ◽  
Eglantina Idrizaj ◽  
Roberta Squecco ◽  
Tommaso Mello ◽  
...  
Keyword(s):  
G Protein ◽  
Oestrogen Receptor ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert ◽  
Anti Inflammatory ◽  
Cholinergic Neurones ◽  
G Protein Coupled

scholarly journals The human G protein‐coupled ATP receptor P2Y 11 is a target for anti‐inflammatory strategies

2021 ◽  
Author(s):  
Georg Gruenbacher ◽  
Hubert Gander ◽  
Gabriele Dobler ◽  
Andrea Rahm ◽  
Dominik Klaver ◽  
...  
Keyword(s):  
G Protein ◽  
Anti Inflammatory ◽  
G Protein Coupled

G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto

2020 ◽  
Vol 277 (4) ◽  
pp. 1121-1127
Author(s):  
Saime Sagiroglu ◽  
Metin Kılınc ◽  
Adem Doganer ◽  
Nagihan Bilal ◽  
Israfil Orhan ◽  
...  
Keyword(s):  
G Protein ◽  
Oestrogen Receptor ◽  
Camp Level ◽  
G Protein Coupled

Relationship between the G protein–coupled oestrogen receptor and spermatogenesis, and its correlation with male infertility

Andrologia ◽  
2020 ◽  
Vol 52 (10) ◽  
Author(s):  
Osman Barut ◽  
Muhammed Seyithanoglu ◽  
Faruk Kucukdurmaz ◽  
Bekir Turkay Demir ◽  
Caner Olmez ◽  
...  
Keyword(s):  
Male Infertility ◽  
G Protein ◽  
Oestrogen Receptor ◽  
G Protein Coupled

scholarly journals Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation

2013 ◽  
Vol 591 (17) ◽  
pp. 4223-4235 ◽  
Author(s):  
G. Cristina Brailoiu ◽  
Khalid Benamar ◽  
Jeffrey B. Arterburn ◽  
Erhe Gao ◽  
Joseph E. Rabinowitz ◽  
...  
Keyword(s):  
G Protein ◽  
Oestrogen Receptor ◽  
Vagal Tone ◽  
Receptor Activation ◽  
Cardiac Vagal Tone ◽  
G Protein Coupled

scholarly journals 590 G protein-coupled oestrogen receptor (GPER) is expressed in melanoma and may predict survival benefit

2017 ◽  
Vol 137 (10) ◽  
pp. S293
Author(s):  
M. Fábián ◽  
P. Balogh ◽  
F. Rencz ◽  
V. Brodszky ◽  
J. Hársing ◽  
...  
Keyword(s):  
G Protein ◽  
Survival Benefit ◽  
Oestrogen Receptor ◽  
G Protein Coupled

Small Molecules that Mimic Components of Bioactive Protein Surfaces

2004 ◽  
Vol 57 (9) ◽  
pp. 855 ◽  
Author(s):  
David P. Fairlie
Keyword(s):  
Amino Acids ◽  
Antiviral Activity ◽  
Small Molecules ◽  
G Protein ◽  
Selective Inhibition ◽  
Structural Components ◽  
Protein Surfaces ◽  
Biological Responses ◽  
Anti Inflammatory ◽  
G Protein Coupled

Small molecules designed to mimic specific structural components of a protein (peptide strands, sheets, turns, helices, or amino acids) can be expected to display agonist or antagonist biological responses by virtue of interacting with the same receptors that recognize the protein. Here we describe some minimalist approaches to structural mimetics of amino acids and of strand, turn, or helix segments of proteins. The designed molecules show potent and selective inhibition of protease, transferase, and phospholipase enzymes, or antagonism of G-protein coupled or transcriptional receptors, and have potent anti-tumour, anti-inflammatory, or antiviral activity.

scholarly journals The Controversial C5a Receptor C5aR2: Its Role in Health and Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Ting Zhang ◽  
Malgorzata A. Garstka ◽  
Ke Li
Keyword(s):  
Animal Models ◽  
G Protein ◽  
Cellular Localization ◽  
G Protein Coupled Receptor ◽  
C5a Receptor ◽  
Intracellular Signals ◽  
Health And Disease ◽  
Anti Inflammatory ◽  
G Protein Coupled

After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form. As a heptahelical G protein-coupled receptor but devoid of the intracellular Gα signal, C5aR2 is special and confusing. Ramifications and controversies about C5aR2 are under debate since its identification, from putative ligands and cellular localization to intracellular signals and pathological roles in inflammation and immunity. The ruleless and even conflicting pro- or anti-inflammatory role of C5aR2 in animal models of diverse diseases makes one bewildered. This review summarizes reports on C5aR2, tries to clear up available evidence on these four controversial aspects, and delineates C5aR2 function(s). It also summarizes available toolboxes for C5aR2 study.

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