Small Molecules that Mimic Components of Bioactive Protein Surfaces
Keyword(s):
Small molecules designed to mimic specific structural components of a protein (peptide strands, sheets, turns, helices, or amino acids) can be expected to display agonist or antagonist biological responses by virtue of interacting with the same receptors that recognize the protein. Here we describe some minimalist approaches to structural mimetics of amino acids and of strand, turn, or helix segments of proteins. The designed molecules show potent and selective inhibition of protease, transferase, and phospholipase enzymes, or antagonism of G-protein coupled or transcriptional receptors, and have potent anti-tumour, anti-inflammatory, or antiviral activity.
2009 ◽
Vol 106
(10)
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pp. 3930-3934
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2005 ◽
Vol 33
(1)
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pp. 291-293
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2007 ◽
Vol 18
(8)
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pp. 2960-2969
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2007 ◽
Vol 283
(3)
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pp. 1525-1533
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2008 ◽
Vol 51
(17)
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pp. 5297-5303
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