The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application

Time-intensity trade for selected spondaically stressed words was investigated using a centering method for interaural time delays of 0.00, 1.00, 2.00, 2.25, 2.50, and 2.75 msec at five levels of presentation: 0-, 25-, 40-, 55-, and 70-dB HL (ANSI, 1969). Lateralization effects increased with level of presentation, with a maximum lateralization effect of between 22 and 30 dB occuring with an interaural time delay of 2.25 msec. Multiple images were perceived by all subjects with an interaural time delay of 2.75 msec and by some subjects with an interaural time delay of 2.50 msec at high levels of presentation. No “ear effect” was observed for any of the listeners. A potential clinical application is discussed for this temporal speech-Stenger effect.

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Human TSH receptor ligands as pharmacological probes with potential clinical application

Expert Review of Endocrinology & Metabolism ◽

10.1586/eem.09.36 ◽

2009 ◽

Vol 4 (6) ◽

pp. 669-679 ◽

Cited By ~ 18

Author(s):

Susanne Neumann ◽

Bruce M Raaka ◽

Marvin C Gershengorn

Keyword(s):

Clinical Application ◽

Tsh Receptor ◽

Receptor Ligands ◽

Potential Clinical Application

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Circulating MicroRNAs in Blood and Other Body Fluids as Biomarkers for Diagnosis, Prognosis, and Therapy Response in Lung Cancer

Diagnostics ◽

10.3390/diagnostics11030421 ◽

2021 ◽

Vol 11 (3) ◽

pp. 421

Author(s):

Luis Vicente Gayosso-Gómez ◽

Blanca Ortiz-Quintero

Keyword(s):

Lung Cancer ◽

Clinical Application ◽

Therapy Response ◽

Body Fluids ◽

Response To Treatment ◽

Circulating Mirnas ◽

Circulating Micrornas ◽

Non Invasive ◽

Potential Value ◽

Potential Clinical Application

The identification of circulating microRNAs (miRNAs) in peripheral blood and other body fluids has led to considerable research interest in investigating their potential clinical application as non-invasive biomarkers of cancer, including lung cancer, the deadliest malignancy worldwide. Several studies have found that alterations in the levels of miRNAs in circulation are able to discriminate lung cancer patients from healthy individuals (diagnosis) and are associated with patient outcome (prognosis) and treatment response (prediction). Increasing evidence indicates that circulating miRNAs may function as mediators of cell-to-cell communication, affecting biological processes associated with tumor initiation and progression. This review is focused on the most recent studies that provide evidence of the potential value of circulating miRNAs in blood and other body fluids as non-invasive biomarkers of lung cancer in terms of diagnosis, prognosis, and response to treatment. The status of their potential clinical application in lung cancer is also discussed, and relevant clinical trials were sought and are described. Because of the relevance of their biological characteristics and potential value as biomarkers, this review provides an overview of the canonical biogenesis, release mechanisms, and biological role of miRNAs in lung cancer.

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Letters to the Editor

PEDIATRICS ◽

10.1542/peds.68.4.601 ◽

1981 ◽

Vol 68 (4) ◽

pp. 601-602

Author(s):

M. Spino ◽

J. J. Thiessen ◽

A. Isles ◽

H. Levison ◽

S. M. MacLeod

Keyword(s):

Clinical Application ◽

Drug Concentration ◽

Apparent Volume ◽

Volume Of Distribution ◽

Intravenous Dose ◽

Single Intravenous Dose ◽

Letters To The Editor ◽

Potential Clinical Application ◽

Apparent Volume Of Distribution

We found the report by Feldman et al1 interesting with potential clinical application. However, we would like to point out an error in their determination of the apparent volume of distribution (V) and comment on both their methodology and results. They state that V was calculated by dividing the dose of the drug by the extrapolated y intercept for drug concentration at time 0. This method is correct for a drug which exhibits monoexponential elimination following a single intravenous dose.

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