LDL cholesterol level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes mellitus: A nationwide cohort study

Objective: To investigate the risk of deep neck infection (DNI) in patients with type 1 diabetes mellitus (T1DM). Methods: The database of the Registry for Catastrophic Illness Patients, affiliated to the Taiwan National Health Insurance Research Database, was used to conduct a retrospective cohort study. In total, 5741 patients with T1DM and 22,964 matched patients without diabetes mellitus (DM) were enrolled between 2000 and 2010. The patients were followed up until death or the end of the study period (31 December 2013). The primary outcome was the occurrence of DNI. Results: Patients with T1DM exhibited a significantly higher cumulative incidence of DNI than did those without DM (p < 0.001). The Cox proportional hazards model showed that T1DM was significantly associated with a higher incidence of DNI (adjusted hazard ratio, 10.71; 95% confidence interval, 6.02–19.05; p < 0.001). The sensitivity test and subgroup analysis revealed a stable effect of T1DM on DNI risk. The therapeutic methods (surgical or nonsurgical) did not differ significantly between the T1DM and non-DM cohorts. Patients with T1DM required significantly longer hospitalization for DNI than did those without DM (9.0 ± 6.2 vs. 4.1 ± 2.0 days, p < 0.001). Furthermore, the patients with T1DM were predisposed to DNI at a younger age than were those without DM. Conclusions: T1DM is an independent risk factor for DNI and is associated with a 10-fold increase in DNI risk. The patients with T1DM require longer hospitalizations for DNI and are younger than those without DM.

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Type 1 Diabetes Mellitus and Risks of Major Psychiatric Disorders: A Nationwide Population-Based Cohort Study

Diabetes & Metabolism ◽

10.1016/j.diabet.2022.101319 ◽

2022 ◽

pp. 101319

Author(s):

Mu-Hong Chen ◽

Shih-Jen Tsai ◽

Ya-Mei Bai ◽

Kai-Lin Huang ◽

Tung-Ping Su ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cohort Study ◽

Type 1 Diabetes Mellitus ◽

Psychiatric Disorders ◽

Population Based

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Birthweight is not a risk factor for childhood onset Type 1 diabetes mellitus

Diabetic Medicine ◽

10.1046/j.1464-5491.2000.00311-2.x ◽

2000 ◽

Vol 17 (7) ◽

pp. 552-552 ◽

Cited By ~ 2

Author(s):

E. Stenhouse ◽

H. X. Zhao ◽

B A. Millward

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Risk Factor ◽

Type 1 Diabetes Mellitus ◽

Childhood Onset ◽

Onset Type

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Infant anthropometry, early life infection, and subsequent risk of type 1 diabetes mellitus: a prospective birth cohort study

Pediatric Diabetes ◽

10.1111/j.1399-5448.2010.00693.x ◽

2011 ◽

Vol 12 (4pt1) ◽

pp. 313-321 ◽

Cited By ~ 6

Author(s):

Anne-Louise Ponsonby ◽

Angela Pezic ◽

Jennifer Cochrane ◽

Fergus J Cameron ◽

Mark Pascoe ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cohort Study ◽

Type 1 Diabetes Mellitus ◽

Early Life ◽

Birth Cohort Study ◽

Prospective Birth Cohort ◽

Prospective Birth Cohort Study ◽

Subsequent Risk

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Early Diabetic Nephropathy and Retinopathy in Patients with Type 1 Diabetes Mellitus Attending Sudan Childhood Diabetes Centre

Journal of Diabetes Research ◽

10.1155/2020/7181383 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Hana Ahmed ◽

Tayseer Elshaikh ◽

Mohamed Abdullah

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Type 1 Diabetes ◽

Diabetic Retinopathy ◽

Risk Factor ◽

Diabetic Nephropathy ◽

Type 1 Diabetes Mellitus ◽

Ethnic Group ◽

Childhood Diabetes

Objective. Data on microvascular complications in children and adolescents with type 1 diabetes mellitus (T1DM) in Sudan are scarce. This study was aimed at determining the prevalence of diabetic nephropathy (DN) and retinopathy (DR) and their relationship to certain risk factors in children with T1DM attending the Sudan Childhood Diabetes Centre. Design and Methods. A clinic-based cross-sectional study of 100 patients with T1DM aged 10-18 years. Patients with disease duration exceeding 5 years if the onset of diabetes was prepubertal and 2 years if it was postpubertal were included. Relevant sociodemographic, clinical, and biochemical information was obtained. Blood pressure was measured. The patients were screened for DN and DR using urinary microalbumin estimation and fundus photography, respectively. Results. The frequency of microalbuminuria and diabetic retinopathy was 36% and 33%, respectively. Eleven percent had both retinopathy and microalbuminuria. Seven percent of the patients were found to be hypertensive. Patients with diabetic retinopathy had significantly higher HbA1c levels ( p = 0.009 ) and longer diabetes duration ( p = 0.02 ) than patients without retinopathy. Logistic regression showed that high HbA1c (odds ratio (OR) 0.83, confidence interval (CI) 0.68-1.00, p = 0.04 ), but not age, duration, ethnic group, BMI, blood pressure, and presence of nephropathy, was an independent risk factor for retinopathy. Likewise, high blood pressure (OR 6.89, CI 1.17-40.52, p = 0.03 ), but not age, duration, ethnic group, BMI, HbA1c, and presence of retinopathy, was a predictor for nephropathy. Conclusion. High prevalence of incipient DN and early stages of DR were observed in this study. Longer diabetes duration and higher HbA1c were associated with the presence of diabetic retinopathy. High blood pressure was a risk factor for DN. So regular screening for these complications and optimization of glycemic control are needed.

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