The Impact of MRI T1 Hypointense Brain Lesions on Cerebral Deep Gray Matter Volume Measures in Multiple Sclerosis

2019 ◽  
Author(s):  
Korhan Buyukturkoglu ◽  
Enricomaria Mormina ◽  
Philip L. Jager ◽  
Claire S. Riley ◽  
Victoria M. Leavitt
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Lesions ◽  
Matter Volume ◽  
Deep Gray Matter ◽  
The Impact

scholarly journals Sample size requirements for one-year treatment effects using deep gray matter volume from 3T MRI in progressive forms of multiple sclerosis

2017 ◽  
Vol 127 (11) ◽  
pp. 971-980 ◽  
Author(s):  
Gloria Kim ◽  
Renxin Chu ◽  
Fawad Yousuf ◽  
Shahamat Tauhid ◽  
Lynn Stazzone ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sample Size ◽  
Gray Matter ◽  
Treatment Effects ◽  
Gray Matter Volume ◽  
3T Mri ◽  
Matter Volume ◽  
Deep Gray Matter ◽  
One Year

scholarly journals Deep gray matter volume loss drives disability worsening in multiple sclerosis

2018 ◽  
Vol 83 (2) ◽  
pp. 210-222 ◽  
Author(s):  
Arman Eshaghi ◽  
Ferran Prados ◽  
Wallace J. Brownlee ◽  
Daniel R. Altmann ◽  
Carmen Tur ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Loss ◽  
Matter Volume ◽  
Deep Gray Matter

Association of Age at Onset With Gray Matter Volume and White Matter Microstructural Abnormalities in People With Multiple Sclerosis

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012869
Author(s):  
Raffaello Bonacchi ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Olga Marchesi ◽  
Andrea Falini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Linear Models ◽  
Gray Matter Volume ◽  
Age At Onset ◽  
Healthy Controls ◽  
Compensatory Mechanisms ◽  
Cross Sectional ◽  
Matter Volume

Objective:To investigate whether age at onset influences brain gray matter volume (GMV) and white matter (WM) microstructural abnormalities in adult multiple sclerosis (MS) patients, given its influence on clinical phenotype and disease course.Method:In this hypothesis-driven cross-sectional study, we enrolled 67 pediatric-onset MS (POMS) patients and 143 sex- and disease duration (DD)-matched randomly-selected adult-onset MS (AOMS) patients, together with 208 healthy controls. All subjects underwent neurological evaluation and 3T MRI acquisition. MRI variables were standardized based on healthy controls, to remove effects of age and sex. Associations with DD in POMS and AOMS patients were studied with linear models. Time to reach clinical and MRI milestones was assessed with product-limit approach.Results:At DD=1 year, GMV and WM fractional anisotropy (FA) were abnormal in AOMS but not in POMS patients. Significant interaction of age at onset (POMS vs AOMS) into the association with DD was found for GMV and WM FA. The crossing point of regression lines in POMS and AOMS patients was at 20 years of DD for GMV and 14 for WM FA. For POMS and AOMS patients, median DD was 29 and 19 years to reach Expanded Disability Status Scale=3 (p<0.001), 31 and 26 years to reach abnormal Paced Auditory Serial Addition Task-3 (p=0.01), 24 and 18 years to reach abnormal GMV (p=0.04), and 19 and 17 years to reach abnormal WM FA (p=0.36).Conclusions:Younger patients are initially resilient to MS-related damage. Then, compensatory mechanisms start failing with loss of WM integrity, followed by GM atrophy and finally disability.

P 3 Cerebellar gray matter volume decrease is associated with epileptic seizures in multiple sclerosis

2017 ◽  
Vol 128 (10) ◽  
pp. e327
Author(s):  
M. Grothe ◽  
M. Süße ◽  
F. von Podewils ◽  
S. Langner ◽  
M. Lotze ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Epileptic Seizures ◽  
Matter Volume ◽  
Cerebellar Gray Matter ◽  
Volume Decrease

The role of global and regional gray matter volume decrease in multiple sclerosis

2016 ◽  
Vol 263 (6) ◽  
pp. 1137-1145 ◽  
Author(s):  
Matthias Grothe ◽  
Martin Lotze ◽  
Sönke Langner ◽  
Alexander Dressel
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Volume Decrease

The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population

2016 ◽  
Vol 171 (3) ◽  
pp. 396-401 ◽  
Author(s):  
Liang Huang ◽  
Yin Mo ◽  
Xuejin Sun ◽  
Hualin Yu ◽  
Hao Li ◽  
...  
Keyword(s):  
Gray Matter ◽  
Chinese Population ◽  
Allelic Variation ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
The Impact

scholarly journals Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor

2007 ◽  
Vol 16 (22) ◽  
pp. 2659-2668 ◽  
Author(s):  
Robert Zivadinov ◽  
Bianca Weinstock-Guttman ◽  
Ralph Benedict ◽  
Miriam Tamaño-Blanco ◽  
Sara Hussein ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Neurotrophic Factor ◽  
Gray Matter Volume ◽  
Brain Derived Neurotrophic Factor ◽  
Matter Volume ◽  
Multiple Sclerosis Patients

scholarly journals Developmental Patterning of Irritability Enhances Prediction of Psychopathology in Pre-adolescence: Improving RDoC with Developmental Science

2020 ◽  
Author(s):  
Katherine S. F. Damme ◽  
Lauren S. Wakschlag ◽  
Margaret J. Briggs-Gowan ◽  
Elizabeth S. Norton ◽  
Vijay A. Mittal
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Interactive Effect ◽  
Volume Growth ◽  
Externalizing Symptoms ◽  
Preschool Age ◽  
Internalizing Behavior ◽  
School Age ◽  
Matter Volume ◽  
The Impact

AbstractResearch has demonstrated the transdiagnostic importance of irritability in psychopathology pathways but the contribution of developmentally-unfolding patterns has only recently been explored. To address this question, irritability patterns of 110 youth from a large and diverse early childhood cohort were assessed at preschool age and at school age (∼2.5 years later) with a dimensional irritability scale designed to capture the normal:abnormal spectrum. Participants then returned at Pre-adolescence (∼6 years later) for an assessment with a structured clinical interview (internalizing/externalizing symptoms) and a magnetic resonance imaging scan. When only preschool age irritability was considered, this was a transdiagnostic predictor of internalizing and externalizing symptoms. However, a model including both preschool and school age irritability provided a more nuanced picture. A high preschool and decreasing school age profile of irritability predicted elevated pre-adolescence internalizing symptoms, potentially reflecting emerging coping/internalizing behavior in pre-adolescence. In contrast, a stable irritability profile across these timepoints predicted increased pre-adolescence externalizing symptoms. Further, preschool irritability (a period of rapid growth) did not predict pre-adolescent gray matter volume abnormality, an indicator of transdiagnostic clinical risk. However, irritability at school age (when gray matter volume growth is largely finished) demonstrated an interactive effect among regions; increased school age irritability predicted reduced volume in pre-adolescence emotional regions (e.g., amygdala, medial orbitofrontal cortex) and increased volume in other regions (e.g., cerebellum). Expanding the impact of RDoC’s approach yielding transdiagnostic phenotypes and multiple units of analysis, a developmentally informed approach provides critical new insights into the complex unfolding of mechanisms underlying emerging psychopathology.

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