scholarly journals Prognostic value of echocardiographic indices of left atrial morphology and function in dogs with myxomatous mitral valve disease

2018 ◽  
Vol 32 (3) ◽  
pp. 914-921 ◽  
Author(s):  
Marco Baron Toaldo ◽  
Giovanni Romito ◽  
Carlo Guglielmini ◽  
Alessia Diana ◽  
Nazzareno G. Pelle ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Left Atrial ◽  
Prognostic Value ◽  
Valve Disease ◽  
And Function

scholarly journals Dietary intervention reduces left atrial enlargement in dogs with early preclinical myxomatous mitral valve disease: a blinded randomized controlled study in 36 dogs

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Qinghong Li ◽  
Allison Heaney ◽  
Natalie Langenfeld-McCoy ◽  
Brittany Vester Boler ◽  
Dorothy P. Laflamme
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Left Atrial ◽  
Alternative Energy ◽  
Dietary Intervention ◽  
Valve Disease ◽  
Controlled Study ◽  
Cardiac Health ◽  
Healthy Dogs ◽  
Energy Deprivation

Abstract Background Myxomatous mitral valve disease (MMVD), the most common naturally-occurring heart disease in dogs, is associated with alterations in energy metabolism, oxidative stress and inflammation. Energy deprivation plays a causal role in the development of heart failure. This study was designed to determine if a cardiac protection blend (CPB) of nutrients containing medium-chain triglycerides as an alternative energy source, fish oil to reduce inflammation, antioxidants, and other key nutrients important to cardiac health and function could slow or prevent MMVD progression. Nineteen dogs with early stage MMVD and 17 breed-, age-, and sex-matched healthy dogs were enrolled for a 6-month blinded, placebo-controlled study. Dogs in each cardiac health group were randomly assigned to either control diet (CON) or CPB-supplemented diet. Echocardiography was performed at baseline, 3 months and 6 months. Results No changes were found in healthy dogs. While MMVD-CON dogs had an average 10% increase over baseline in left atrial diameter (LAD) and left atrial to aortic root ratio (LA/Ao) at 6 months, MMVD-CPB dogs showed 3% decreases, resulting significant diet by time interactions (P = 0.037, P = 0.005, respectively). More MMVD-CON dogs progressed from stage B1 to B2 during the study. A positive correlation was found between 6-month changes in LAD and blood pressures in MMVD-CPB dogs (systolic: P = 0.050, diastolic: P = 0.035) but not MMVD-CON dogs. Conclusions Our results demonstrated efficacy of CPB-based dietary intervention in reducing LA size and mitral regurgitation, and in slowing or preventing the progression of early MMVD in dogs.

The role of the left atrial function in the surgical management of aortic and mitral valve disease

2019 ◽  
Vol 36 (8) ◽  
pp. 1559-1565 ◽  
Author(s):  
Matteo Cameli ◽  
Carlotta Sciaccaluga ◽  
Giulia E. Mandoli ◽  
Flavio D’Ascenzi ◽  
Charilaos Tsioulpas ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Surgical Management ◽  
Mitral Valve Disease ◽  
Left Atrial ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Valve Disease
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