NAD + Metabolism in Cardiac Health, Aging, and Disease

Nicotinamide adenine dinucleotide (NAD + ) is a central metabolite involved in energy and redox homeostasis as well as in DNA repair and protein deacetylation reactions. Pharmacological or genetic inhibition of NAD + -degrading enzymes, external supplementation of NAD + precursors, and transgenic overexpression of NAD + -generating enzymes have wide positive effects on metabolic health and age-associated diseases. NAD + pools tend to decline with normal aging, obesity, and hypertension, which are all major risk factors for cardiovascular disease, and NAD + replenishment extends healthspan, avoids metabolic syndrome, and reduces blood pressure in preclinical models. In addition, experimental elevation of NAD + improves atherosclerosis, ischemic, diabetic, arrhythmogenic, hypertrophic, or dilated cardiomyopathies, as well as different modalities of heart failure. Here, we critically discuss cardiomyocyte-specific circuitries of NAD + metabolism, comparatively evaluate distinct NAD + precursors for their preclinical efficacy, and raise outstanding questions on the optimal design of clinical trials in which NAD + replenishment or supraphysiological NAD + elevations are assessed for the prevention or treatment of major cardiac diseases. We surmise that patients with hitherto intractable cardiac diseases such as heart failure with preserved ejection fraction may profit from the administration of NAD + precursors. The development of such NAD + -centered treatments will rely on technological and conceptual progress on the fine regulation of NAD + metabolism.

Evaluation of plasma N-terminal pro-B-type natriuretic peptide levels in healthy North American Salukis with normal echocardiographic measurements.

Measurement of N‐terminal pro‐B‐type natriuretic peptide (NT-proBNP) levels has been shown to have clinical significance for diagnosis and management of heart disease in dogs. Evaluation of current reference limits for specific breeds is necessary to ensure the test can accurately distinguish between healthy and diseased animals. The objective of this study is to evaluate the adequacy of currently established NT-proBNP reference limits for clinical use in healthy Salukis. Cardiac health of 33 clinically healthy Salukis was evaluated via echocardiography using available breed standards. Plasma concentrations of NT-proBNP were measured using a commercially available assay. A one-sided 97.5% upper reference limit for the NT-proBNP concentrations was calculated using non-parametric percentile method. The 97.5% upper reference limit was 769 pmol/L (90% CI, 547-1214 pmol/L) for the study dogs. This upper reference limit was within the currently established non-breed specific NT-proBNP upper reference limit of 900 pmol/L. No relationship between sex, age, or body weight on plasma levels of NT-proBNP was noted. Results of this study supports the use of currently available non-breed specific NT-proBNP cut-off values for clinical evaluation of healthy Salukis.

Meditation and Preventive Cardiac Health

Thanks to advancements in medical and technical therapy, heart failure (HF) patients are now better predicted. A longer lifespan is linked to an increase in the number of risky lifestyle factors and behaviours that put a person at risk for heart failure (HF) early on in life. Doctors dealing with this challenging illness place emphasis only on medicinal products or medical equipment, although changes in lifestyles may assist to prevent and cure heart failure and are often neglected. The effects of weight reduction and exercise on cardiovascular disease (HF), as well as the impact of nutritional supplements and mindfulness on the illness's causes, physiopathology, and therapy, were studied by researchers.

Retraction Notice To: Potential Health Benefits of Broccoli-A Chemico-Biological Overview

The article “Potential health benefits of broccoli- a chemico-biological overview, published in Mini-Rev Med Chem 2009 Jun;9(6):749-59. By Hannah R. Vasanthi, Subhendu Mukherjee and Dipak K. Das” has been retracted by the Editorial office of the journal Mini-reviews in Medicinal Chemistry, as the text in this review article are from sources which have been retracted or under investigation on the basis of data fabrication and falsification, authorship misconduct, duplicate publication, unethical research practices, text recycling/self-plagiarism, and unresolved concerns about data integrity and research conduct. The authors were informed of this complaint and were requested to give justification on the matter in their defense [1]. Some sources that have been retracted are as follows: 1) Agarwal et al. Dynamic Action of Carotenoids in Cardioprotection and Maintenance of Cardiac Health, Molecules 2012, 17, 4755-4769. http: https://pubmed.ncbi.nlm.nih.gov/24896014/ 2) Nagendran Balasundram, KalyanaSundram, SamirSamman. Phenolic compounds in plants and agri-industrial byproducts: Antioxidant activity, occurrence, and potential uses. Food Chemistry 2006, 99(1), 191-203. https://www.sciencedirect.com/science/article/abs/pii/S0308814605006242 Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Retraction can be found at https://benthamscience.com/editorial-policies-main.php. REFERENCES [1] Hannah R Vasanthi, Subhendu Mukherjee, Dipak K Das. Potential health benefits of broccoli- a chemico-biological overview. Mini Rev Med Chem., 2009, 9(6), 749-759. doi: 10.2174/138955709788452685. https://pubmed.ncbi.nlm.nih.gov/19519500/ Bentham Science Disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.