Trans-Vaginal Mesh Revision: A Comprehensive Review on Etiologies and Management Strategies with Emphasis on Postoperative Pain Outcomes

The digital transformation of healthcare is advancing, leading to an increasing availability of clinical data for research. Perioperative big data initiatives were established to monitor treatment quality and benchmark outcomes. However, big data analyzes have long exceeded the status of pure quality surveillance instruments. Large retrospective studies nowadays often represent the first approach to new questions in clinical research and pave the way for more expensive and resource intensive prospective trials. As a consequence, utilization of big data in acute pain and regional anesthesia research considerably increased over the last decade. Multicentric clinical registries and administrative databases (e.g., healthcare claims databases) have collected millions of cases until today, on which basis several important research questions were approached. In acute pain research, big data was used to assess postoperative pain outcomes, opioid utilization, and the efficiency of multimodal pain management strategies. In regional anesthesia, adverse events and potential benefits of regional anesthesia on postoperative morbidity and mortality were evaluated. This article provides a narrative review on the growing importance of big data for research in acute postoperative pain and regional anesthesia.

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Big Data in Studying Acute Pain and Regional Anesthesia

Journal of Clinical Medicine ◽

10.3390/jcm10071425 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1425

Author(s):

Lukas M. Müller-Wirtz ◽

Thomas Volk

Keyword(s):

Big Data ◽

Postoperative Pain ◽

Regional Anesthesia ◽

Acute Pain ◽

Management Strategies ◽

Administrative Databases ◽

Treatment Quality ◽

Clinical Registries ◽

Pain Outcomes ◽

The Status

The digital transformation of healthcare is advancing, leading to an increasing availability of clinical data for research. Perioperative big data initiatives were established to monitor treatment quality and benchmark outcomes. However, big data analyses have long exceeded the status of pure quality surveillance instruments. Large retrospective studies nowadays often represent the first approach to new questions in clinical research and pave the way for more expensive and resource intensive prospective trials. As a consequence, the utilization of big data in acute pain and regional anesthesia research has considerably increased over the last decade. Multicentric clinical registries and administrative databases (e.g., healthcare claims databases) have collected millions of cases until today, on which basis several important research questions were approached. In acute pain research, big data was used to assess postoperative pain outcomes, opioid utilization, and the efficiency of multimodal pain management strategies. In regional anesthesia, adverse events and potential benefits of regional anesthesia on postoperative morbidity and mortality were evaluated. This article provides a narrative review on the growing importance of big data for research in acute postoperative pain and regional anesthesia.

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A Multi-center Registry Study: The Follow-up the Complications for Trans-vaginal Mesh Surgery

Case Medical Research ◽

10.31525/ct1-nct04025047 ◽

2019 ◽

Author(s):

Keyword(s):

Vaginal Mesh ◽

Registry Study ◽

Mesh Surgery ◽

Trans Vaginal Mesh

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Faculty Opinions recommendation of Transversus abdominis plane block to ameliorate postoperative pain outcomes after laparoscopic surgery: a meta-analysis of randomized controlled trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718246145.793511432 ◽

2015 ◽

Author(s):

Jan Jakobsson

Keyword(s):

Laparoscopic Surgery ◽

Postoperative Pain ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Transversus Abdominis Plane Block ◽

Transversus Abdominis ◽

Controlled Trials ◽

Transversus Abdominis Plane ◽

Randomized Controlled ◽

Pain Outcomes

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Outcomes and complications of trans-vaginal mesh repair using the Prolift™ kit for pelvic organ prolapse at 4 years median follow-up in a tertiary referral centre

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-014-3316-3 ◽

2014 ◽

Vol 290 (6) ◽

pp. 1151-1157 ◽

Cited By ~ 13

Author(s):

Zainab A. Khan ◽

Lee Thomas ◽

Simon J. Emery

Keyword(s):

Pelvic Organ Prolapse ◽

Mesh Repair ◽

Pelvic Organ ◽

Vaginal Mesh ◽

Referral Centre ◽

Tertiary Referral ◽

Tertiary Referral Centre ◽

Trans Vaginal Mesh ◽

Vaginal Mesh Repair

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Toward Identifying Moderators of Associations Between Presurgery Emotional Distress and Postoperative Pain Outcomes: A Meta-Analysis of Longitudinal Studies

Journal of Pain ◽

10.1016/j.jpain.2016.04.003 ◽

2016 ◽

Vol 17 (8) ◽

pp. 874-888 ◽

Cited By ~ 21

Author(s):

Todd Jackson ◽

Panpan Tian ◽

Yang Wang ◽

Tony Iezzi ◽

Wenyi Xie

Keyword(s):

Postoperative Pain ◽

Longitudinal Studies ◽

Emotional Distress ◽

Meta Analysis ◽

Pain Outcomes

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Impact of the Timing of Rocuronium Injection after Propofol Administration on Temporal Summation of Pain in Gynecologic Laparoscopic Surgery: A Prospective and Controlled Study

Pain Research and Management ◽

10.1155/2020/6642460 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Jaehak Jung ◽

Byoungryun Kim ◽

Seong Nam Park ◽

Jiheui Lee ◽

Insung Choi ◽

...

Keyword(s):

Laparoscopic Surgery ◽

Postoperative Pain ◽

Temporal Summation ◽

Opioid Consumption ◽

Controlled Study ◽

Injection Pain ◽

Pain Patient ◽

Patient Controlled Analgesia ◽

Pain Outcomes ◽

The Impact

Purpose. Temporal summation of pain, which is defined as the perception of greater pain evoked by repetitive painful stimuli, varies among individuals. This study aimed at determining the impact of the timing of rocuronium after induction with propofol on the temporal summation of pain. Methods. One hundred patients aged 19–60 years underwent gynecologic laparoscopic surgery. Patients were randomly assigned to one of the two groups: group PRi received immediate injections of rocuronium after propofol administration and group PRd received rocuronium injections when the bispectral index score (BIS) decreased to <60 after propofol administration. The grade of rocuronium-induced withdrawal movement (RIWM) according to the timing of propofol injection, the incidence and severity of propofol injection pain (PIP), rescue analgesics, visual analog scale (VAS) score after surgery for postoperative pain, patient-controlled analgesia (PCA) opioid consumption, association between PIP and the grade of RIWM, and associations between PIP, the grade of RIWM, and postoperative pain outcomes were measured. Results. The differences between the incidence and severity of PIP in the two groups were not significant. The grade of the RIWM in the PRd group was significantly reduced compared with the PRi group. Rescue analgesics, severity for postoperative pain, and PCA opioid consumption were not significant. Correlations between the incidence and severity of PIP and the grade of RIWM were weakly negative. Correlations between the grade of RIWM and pain outcomes were moderately positive, but correlations between the severity for PIP and the postoperative pain outcomes were negligible. Conclusion. The timing of rocuronium administration after propofol injection played a role in reducing RIWM. The grade of RIWM was significantly related to pain outcomes compared with the severity of PIP. Therefore, delayed rocuronium injection after induction with propofol reduced temporal summation of pain.

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