Molecular characterization of oral squamous cell carcinoma using targeted next-generation sequencing

Oral Diseases ◽  
2015 ◽  
Vol 21 (7) ◽  
pp. 872-878 ◽  
Author(s):  
Tze-Kiong Er ◽  
Yen-Yun Wang ◽  
Chih-Chieh Chen ◽  
Marta Herreros-Villanueva ◽  
Ta-Chih Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Molecular Characterization ◽  
Squamous Cell ◽  
Next Generation ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

Molecular Characterization of Oral Squamous Cell Carcinoma and Dysplasia Using Next Generation Sequencing

2015 ◽  
Vol 119 (3) ◽  
pp. e178-e179
Author(s):  
Özkan Büyük ◽  
Yeşim Yıldız ◽  
Margarete Odenthal ◽  
Reinhard Büttner ◽  
Sibel Elif Gültekin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Molecular Characterization ◽  
Squamous Cell ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma

Tumor Biology ◽  
2018 ◽  
Vol 40 (9) ◽  
pp. 101042831880018 ◽  
Author(s):  
Takafumi Nakagaki ◽  
Miyuki Tamura ◽  
Kenta Kobashi ◽  
Akina Omori ◽  
Ryota Koyama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Japanese Patients ◽  
Next Generation ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

Abstract 4905: Comprehensive genomic analyses of oral squamous cell carcinoma tissues by semiconductor-based next-generation sequencing

2015 ◽  
Author(s):  
Takafumi Nakagaki ◽  
Yasushi Sasaki ◽  
Kenta Kobashi ◽  
Kousuke Takeda ◽  
Miyuki Tamura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Next Generation ◽  
Genomic Analyses ◽  
Generation Sequencing

scholarly journals Bacteriome Identified by Next-Generation Sequencing in Saliva, Dental Plaque, and Tumor Tissue of Patients with Oral Squamous Cell Carcinoma

2021 ◽  
Vol 15 (1) ◽  
pp. 98-110
Author(s):  
Alveiro Erira ◽  
Dabeiba Adriana García Robayo ◽  
Andrés Ignacio Chalá ◽  
Andrei Moreno Torres ◽  
Eliana Elisa Muñoz Lopez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Legionella Pneumophila ◽  
Dental Plaque ◽  
Bacterial Species ◽  
Next Generation ◽  
Generation Sequencing

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world, and the bacterial microbiome has been considered a risk factor that could play an important role in carcinogenesis. Objective: A bacteriome study was performed by next-generation sequencing in dental plaque, saliva, and tumor samples of 10 OSCC patients and compared with bacteriome in dental plaque and saliva of 10 patients without OSCC. Methods: DNA was extracted from all samples and sequenced by Illumina technology MiSeq™. Bioinformatic analyzes were performed for evaluated sequence quality, alpha and beta diversity, bidirectional analysis of variance (p <0.05), and principal component analysis. After establishing bacterial profiles associated with each sample and population, intragroup and intergroup comparisons were carried out. For bacteria identification compatible with eubiosis and dysbiosis processes, a screening was performed based on the frequency of appearance in all patient samples with and without OSCC. Lastly, frequency, average, standard deviation, Chi-square, and Mann Whitney test were calculated. Results: Out of the identified 1,231 bacteria in the populations under study, 45 bacterial species were selected, of which 34 were compatible with eubiosis, and 11 were compatible with dysbiosis. Among the bacteria compatible with eubiosis were species of Lactobacillus and Streptococcus, Chromobacterium violaceum, Enterobacter asburiae, Mycobacterium chubuense, Mycoplasma penetrans, and Brachyspira intermedia. Among the species associated with dysbiosis,  Providencia stuartii, Capnocytophaga canimorsus, Legionella pneumophila, and Mycoplasma hominis were notable. Conclusion: Thirty-four bacterial species may be associated with eubiosis or healthy states and 11 bacterial species could be associated with dysbiosis or pathogenic state, OSCC.

scholarly journals Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma

2019 ◽  
Vol 51 (1) ◽  
pp. 300-312 ◽  
Author(s):  
Sun Min Lim ◽  
Sang Hee Cho ◽  
In Gyu Hwang ◽  
Jae Woo Choi ◽  
Hyun Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Next Generation ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

scholarly journals Investigating the feasibility of targeted next-generation sequencing to guide the treatment of head and neck squamous cell carcinoma.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e18017-e18017
Author(s):  
Bhumsuk Keam ◽  
Sun Min Lim ◽  
Sang-Hee Cho ◽  
In Gyu Hwang ◽  
Myung-Ju Ahn ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Next Generation ◽  
Targeted Next Generation Sequencing ◽  
Generation Sequencing

scholarly journals Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing

2016 ◽  
Vol 22 (7) ◽  
pp. 2284-2293 ◽  
Author(s):  
Yasushi Sasaki ◽  
Miyuki Tamura ◽  
Ryota Koyama ◽  
Takafumi Nakagaki ◽  
Yasushi Adachi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Next Generation Sequencing ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Next Generation ◽  
Genomic Characterization ◽  
Generation Sequencing
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