Histochemical localization of putative stem cells in irreversible pulpitis

Oral Diseases ◽  
2021 ◽  
Author(s):  
Yan Wu ◽  
Caixia Zhou ◽  
Xueying Tong ◽  
Shue Li ◽  
Jiarong Liu
Keyword(s):  
Stem Cells ◽  
Histochemical Localization ◽  
Irreversible Pulpitis

Isolation and Characterization of Human Dental Pulp Stem Cells from Cryopreserved Pulp Tissues Obtained from Teeth with Irreversible Pulpitis

2016 ◽  
Vol 42 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Azin Malekfar ◽  
Kusum S. Valli ◽  
Mohammad Mahboob Kanafi ◽  
Ramesh R. Bhonde
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Isolation And Characterization ◽  
Human Dental Pulp ◽  
Irreversible Pulpitis

scholarly journals Comparative Analysis of Proliferation and Differentiation Potentials of Stem Cells from Inflamed Pulp of Deciduous Teeth and Stem Cells from Exfoliated Deciduous Teeth

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Shi Yu ◽  
Shu Diao ◽  
Jinsong Wang ◽  
Gang Ding ◽  
Dongmei Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tissue Regeneration ◽  
Deciduous Teeth ◽  
Inflammatory Factors ◽  
Dental Tissue ◽  
Significant Difference ◽  
Proliferation And Differentiation ◽  
Cell Sources ◽  
Irreversible Pulpitis

Stem cells isolated from exfoliated deciduous teeth (SHEDs) are highly capable of proliferation and differentiation, and they represent good cell sources for mesenchymal stem cell- (MSC-) mediated dental tissue regeneration, but the supply of SHEDs is limited. A previous study found that stem cells could be isolated from inflamed tissues, but it is unknown whether primary dental pulp diagnosed with irreversible pulpitis might contain stem cells with appropriate tissue regeneration capacity. In this study, we aimed to isolate stem cells from both inflamed pulps of deciduous teeth (SCIDs) and SHEDs from Chinese children and to compare their proliferation and differentiation potentials. Our results showed that SCIDs were positive for cell surface markers, including CD105, CD90, and CD146, and they had high proliferation ability and osteogenic, adipogenic, and chondrogenic differentiation potentials. There was no significant difference in proliferation and differentiation potentials between SCIDs and SHEDs. The mRNA of inflammatory factors, including IL-1β, IL-6, and TNF-α, was expressed at similar levels in SCIDs and SHEDs, but SCIDs secreted more TNF-αprotein. In conclusion, ourin vitroresults showed that SCIDs have proliferation and differentiation potentials similar to those of SHEDs. Thus, SCIDs represent a new potentially applicable source for MSC mediated tissue regeneration.

scholarly journals Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Soichiro Sonoda ◽  
Haruyoshi Yamaza ◽  
Lan Ma ◽  
Yosuke Tanaka ◽  
Erika Tomoda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Interferon Gamma ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp ◽  
Irreversible Pulpitis

scholarly journals Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoyao Huang ◽  
Zihan Li ◽  
Anqi Liu ◽  
Xuemei Liu ◽  
Hao Guo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dental Pulp ◽  
Recent Progress ◽  
Bacterial Invasion ◽  
Pulp Regeneration ◽  
Proliferation And Differentiation ◽  
Valuable Method ◽  
Immense Potential ◽  
Irreversible Pulpitis

Dental pulp as a source of nutrition for the whole tooth is vulnerable to trauma and bacterial invasion, which causes irreversible pulpitis and pulp necrosis. Dental pulp regeneration is a valuable method of restoring the viability of the dental pulp and even the whole tooth. Odontogenic mesenchymal stem cells (MSCs) residing in the dental pulp environment have been widely used in dental pulp regeneration because of their immense potential to regenerate pulp-like tissue. Furthermore, the regenerative abilities of odontogenic MSCs are easily affected by the microenvironment in which they reside. The natural environment of the dental pulp has been proven to be capable of regulating odontogenic MSC homeostasis, proliferation, and differentiation. Therefore, various approaches have been applied to mimic the natural dental pulp environment to optimize the efficacy of pulp regeneration. In addition, odontogenic MSC aggregates/spheroids similar to the natural dental pulp environment have been shown to regenerate well-organized dental pulp both in preclinical and clinical trials. In this review, we summarize recent progress in odontogenic MSC-mediated pulp regeneration and focus on the effect of the microenvironment surrounding odontogenic MSCs in the achievement of dental pulp regeneration.

scholarly journals Putative Stem Cells in Human Dental Pulp with Irreversible Pulpitis: An Exploratory Study

2010 ◽  
Vol 36 (5) ◽  
pp. 820-825 ◽  
Author(s):  
Zhengyan Wang ◽  
Jian Pan ◽  
John T. Wright ◽  
Sompop Bencharit ◽  
Shaoping Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Exploratory Study ◽  
Human Dental Pulp ◽  
Irreversible Pulpitis

Biomaterial Control of Therapeutic Stem Cells

2019 ◽  
Keyword(s):  
Stem Cells

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

Repair of deep skin burn defects with cultured epidermal stem cells and acellular amniotic membranes

2010 ◽  
Vol 34 (8) ◽  
pp. S39-S39
Author(s):  
Dewu Liu ◽  
Honglan Xiong ◽  
Yuangui Mao ◽  
Peixin Huang ◽  
Jianping Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Epidermal Stem Cells ◽  
Skin Burn ◽  
Amniotic Membranes

Controlling the in vitro differentiation of embryonic stem cells for myocardial tissue engineering applications

2009 ◽  
Author(s):  
Dong-Bo Ou ◽  
Rui Chen ◽  
Xiong-Tao Liu ◽  
Jing-Jing Guo ◽  
Hong-Tao Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Myocardial Tissue ◽  
In Vitro Differentiation ◽  
Engineering Applications ◽  
Myocardial Tissue Engineering

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent
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