Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation

2014 ◽  
Vol 27 (4) ◽  
pp. 580-589 ◽  
Author(s):  
Bhushan Sarode ◽  
Craig S. Nowell ◽  
JongEun Ihm ◽  
Corinne Kostic ◽  
Yvan Arsenijevic ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Ciliary Body ◽  
Body Development ◽  
Anterior Eye Segment ◽  
Pigmented Epithelium

Notch Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression

2019 ◽  
Author(s):  
Ji Pang ◽  
Liang Le ◽  
Yi Zhou ◽  
Qiang Hou ◽  
Marina Thexton ◽  
...  
Keyword(s):  
Protein Expression ◽  
Notch Signaling ◽  
Ciliary Body

scholarly journals DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells.

1986 ◽  
Vol 34 (11) ◽  
pp. 1465-1468 ◽  
Author(s):  
R A Stone ◽  
A M Laties ◽  
H C Hemmings ◽  
C C Ouimet ◽  
P Greengard
Keyword(s):  
Ciliary Body ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
Secretory Cells ◽  
Ciliary Epithelium ◽  
Receptor Subtype ◽  
Physiological Effects ◽  
Body Extract ◽  
Innermost Layer ◽  
Pigmented Epithelium

DARPP-32, a phosphoprotein enriched in dopaminoceptive brain neurons containing the D-1 receptor subtype, probably functions as an intracellular third messenger to mediate some of the physiological effects of dopamine at the D-1 receptor. By immunohistochemistry in rat, cat, Rhesus monkey, and human, we have localized DARPP-32 to the non-pigmented epithelium of the ciliary body, the innermost layer of the bi-layered epithelium responsible for secretion of aqueous humor into the eye. The immunoreactive protein in rat ciliary body, identified by immunolabeling of a ciliary body extract separated by sodium dodecyl sulfate/polyacrylamide gel electrophoresis, is indistinguishable from DARPP-32 derived from rat caudatoputamen. By analogy with brain, we propose that DARPP-32 may act as a third messenger in the ciliary epithelium, probably through a dopaminergic mechanism.

scholarly journals Determining the impact of form deprived vision on guinea pig ciliary body development

2017 ◽  
Vol 17 (15) ◽  
pp. 35
Author(s):  
Andrew Pucker ◽  
Ashley R. Jackson ◽  
Kirk M. McHugh ◽  
Donald O. Mutti
Keyword(s):  
Guinea Pig ◽  
Ciliary Body ◽  
Body Development ◽  
The Impact

Selective Destruction of the Pigmented Epithelium in the Ciliary Body of the Eye

Science ◽  
1974 ◽  
Vol 184 (4143) ◽  
pp. 1298-1299 ◽  
Author(s):  
S. Okisaka ◽  
T. Kuwabara ◽  
S. I. Rapoport
Keyword(s):  
Ciliary Body ◽  
Selective Destruction ◽  
Pigmented Epithelium
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