Nail discoloration in pediatric skin of color patients

Nail discoloration

Nail in Differential Diagnosis ◽

10.1201/b14866-7 ◽

2006 ◽

pp. 89-118

Keyword(s):

Nail Discoloration

Nail discoloration in a child with brucellosis

Community Acquired Infection ◽

10.4103/2225-6482.172653 ◽

2015 ◽

Vol 2 (4) ◽

pp. 148

Author(s):

SonerSertan Kara ◽

NurhanDoner Aktas

Keyword(s):

Nail Discoloration

The Effect of Nail Lacquer on Taxane-Induced Nail Changes in Women With Breast Cancer

Breast Cancer Basic and Clinical Research ◽

10.1177/1178223420929702 ◽

2020 ◽

Vol 14 ◽

pp. 117822342092970

Author(s):

Osama Alshari ◽

Abdelwahab Aleshawi ◽

Ahmed H Al Sharie ◽

Ala’a Msameh ◽

Isra Al-Omari ◽

...

Keyword(s):

Breast Cancer ◽

Observational Study ◽

Statistical Significance ◽

Statistical Association ◽

Female Patients ◽

Patients With Cancer ◽

Nail Lacquer ◽

Nail Discoloration ◽

Nail Changes ◽

Main Change

Objective: Taxane-induced nail changes are considered as an important cosmetic manifestation with an incidence that reaches up to 44% of patients treated with taxane-included therapeutic regimens. In this article, we represent a clinical observational study to evaluate the effect of cosmetic nail lacquer on taxane-induced nail changes in female patients diagnosed with breast cancer. Methods: Prospectively, we identified those women who were diagnosed with breast cancer, scheduled to have AC-Taxol protocol. Any female with previous dermatological or systemic disorders that affect nails was excluded from the study. Patients were categorized into 2 groups based on the utilization of nail lacquer. The first group includes women who started to use the nail lacquer after development of nail changes. The second group comprises those women who did not use the nail lacquer at any occasion. Results: A total of 59 female patients were included in the study; 46 (78%) of them developed nail changes and the main change was nail discoloration. The first group which has used nail lacquer (17, 28.8%) showed an improvement among 15 (78.9%) patients, whereas 2 (7.4%) of them continued to have worsening symptoms. On the contrary, most of the second group (25, 92.9%) did not show any improvement in nail changes. A statistical significance between the tested groups was observed ( P = .000). There is no statistical association between the progression of nail changes and the age of patients. Conclusions: Taxane-induced nail changes are considered as an important clinical, cosmetic, and psychological complication, especially for female patients with cancer. This article suggests that nail lacquer may have an effect in the improvement of nail changes, especially nail discoloration. Further investigations are recommended to prove the efficacy of nail lacquer.

Bluish-gray fingernail discoloration due to the use of nivolumab

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155220929974 ◽

2020 ◽

pp. 107815522092997

Author(s):

Miguel Michel Ocampo ◽

Jaren Lerner ◽

Constantin A Dasanu

Keyword(s):

Case Report ◽

Immune Checkpoint ◽

Immune Checkpoint Inhibitors ◽

Checkpoint Inhibitors ◽

Skin Toxicity ◽

Unique Case ◽

First Case ◽

Nail Discoloration ◽

Wide Range ◽

Causality Relationship

Introduction Immune checkpoint inhibitors have improved clinical outcomes in a wide range of cancers. While skin toxicity is not uncommon with immune checkpoint inhibitors, generalized nail discoloration has not been reported with their use in oncology. Case report Herein, we report a unique case of bluish-gray fingernail discoloration due to nivolumab therapy for relapsed melanoma. Management and outcome: This condition reversed completely 10 weeks after nivolumab discontinuation. Naranjo nomogram assessment renders the causality relationship between nivolumab and nail discoloration probable. Discussion To our knowledge, this is the first case report of an unusual bluish-gray nail discoloration due to therapy with nivolumab. The mechanism by which nivolumab causes this side effect remains to be elucidated.

Clinical Study of various Nail Disorders presenting to Dermatology Outpatient Department

International Journal of Advanced and Integrated Medical Sciences ◽

10.5005/jp-journals-10050-10090 ◽

2017 ◽

Vol 2 (3) ◽

pp. 125-129

Author(s):

Praveen K Rathore ◽

Sapna Goyal ◽

Anuj Kumar ◽

Parul Garg

Keyword(s):

Clinical Study ◽

Potassium Hydroxide ◽

Outpatient Department ◽

Fungal Culture ◽

Nail Bed ◽

Nail Psoriasis ◽

Medical College ◽

Gram Staining ◽

Nail Discoloration ◽

Pachyonychia Congenita

ABSTRACT Aims and objectives To study the clinical spectrum of nail disorders including congenital, developmental, infectious, neoplastic, degenerative, dermatological, and systemic diseases affecting the nail unit. Materials and methods A total of 100 consecutive cases of nail disorders reporting to the dermatology outpatient department in Rohilkhand Medical College & Hospital were examined. Complete dermatological, systemic, hematological examinations, Gram staining, scraping for fungus, nail clipping for potassium hydroxide mount, fungal culture, biopsy from nail bed were undertaken in doubtful cases. Observations and results Among 100 cases, the most common was onychomycosis — 28 cases, followed by nail psoriasis — 13 cases, pitting — 10 cases, paronychia — 9 cases, trachyonychia — 5 cases, onycholysis — 4 cases, clubbing — 3 cases, koilonychia — 3 cases, ingrow toenail — 3 cases, pterygium — 3 cases, onychogryphosis — 2 cases, subungual wart — 2 cases, half and half nail — 2 cases, anonychia — 2 cases, longitudinal grooves — 2 cases, clubbing with resorption of fingers — 2 cases, onychomadesis — 1 case, nail discoloration — 1 case, melanonychia — 1 case, pachyonychia congenita — 1 case, beau's line — 1 case, racket nail — 1 case, transverse groove — 1 case. Conclusion Among examined cases, onychomycosis was most common followed by another nail disorders. How to cite this article Garg P, Kumar A, Rathore PK, Goyal S. Clinical Study of various Nail Disorders presenting to Dermatology Outpatient Department. Int J Adv Integ Med Sci 2017;2(3):125-129.