Pathogenesis of developmental anomalies of the central nervous system induced by congenital cytomegalovirus infection

2017 ◽  
Vol 67 (2) ◽  
pp. 72-82 ◽  
Author(s):  
Hideya Kawasaki ◽  
Isao Kosugi ◽  
Shiori Meguro ◽  
Toshihide Iwashita
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Developmental Anomalies ◽  
The Central Nervous System

scholarly journals Difficulties in selecting specific therapy in severe forms of congenital cytomegalovirus infection: view through time

2021 ◽  
pp. 82-89
Author(s):  
E.V. Usachova ◽  
◽  
E.A. Silina ◽  
T.N. Pakholchuk ◽  
O.V. Konakova ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytomegalovirus Infection ◽  
Residual Effects ◽  
Congenital Cytomegalovirus Infection ◽  
Specific Therapy ◽  
Congenital Cytomegalovirus ◽  
The Central Nervous System ◽  
Pcr Test ◽  
Clinical Cases

The aim — to show the feasibility of using ganciclovir for congenital cytomegalovirus infection (CMVI) by demonstrating two clinical cases. Clinical cases. Over time, the approaches to the treatment of congenital CMVI have changed from the use of acyclovir to the appointment of ganciclovir. In 2011, a premature baby was diagnosed with congenital CMVI based on the presence of multiple organ lesions (lungs, liver, spleen, pancreas, eyes, central nervous system) and positive result of CMV PCR test in blood, urine and cerebrospinal fluid. Only acyclovir was used as an etiotropic drug due to the lack of evidence at that time on the safety of another antiviral drug — ganciclovir. Treatment was not completely effective: in the follow;up at the age of two the child has a grave violation hearing and vision and profound disability due to the residual effects on the central nervous system. In 2019, a newborn child with severe haemorrhagic syndrome, respiratory disorders and neurological symptoms was diagnosed with congenital CMVI by positive result of CMV PCR test and ganciclovir was prescribed at a dose of 6 mg/kg every 12 hours by an intravenous infusion under the control of a routine complete blood count (CBC) test. On the second week of treatment, positive dynamics was observed clinically, on the 6th week — negative result of CMV PCR test. The child was discharged on day 70th of treatment without residual effects on the central nervous system. At the age of 9 months, deafness of 2–3 degrees was diagnosed, but prosthetics were performed timely with complete restoration of hearing. At age of 12 month this child sits, rolls over, crawls; responds adequately to others; captures the gaze and keep an eye on items. Conclusions. Two clinical cases through the description of changes in approaches to specific therapy of congenital cytomegalovirus disease from acyclovir to ganciclovir and a clear demonstration of the difference in disease outcomes — from severe disability when ganciclovir was not prescribed, to complete rehabilitation with its use demonstrate the feasibility of prescribing ganciclovir. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: congenital cytomegalovirus infection, severe forms, treatment, acyclovir, ganciclovir.

scholarly journals FEATURES OF CENTRAL NERVOUS SYSTEM DAMAGE IN CHILDREN WITH CONGENITAL CYTOMEGALOVIRUS INFECTION

2020 ◽  
Vol 7 (2) ◽  
pp. 89-93
Author(s):  
M. Gonchar ◽  
M. Urivaeva ◽  
G. Muratov ◽  
T. Malich ◽  
O. Omelchenko ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytomegalovirus Infection ◽  
Clinical Observation ◽  
First Year ◽  
Congenital Cytomegalovirus Infection ◽  
Central Nervous System Damage ◽  
Congenital Cytomegalovirus ◽  
First Year Of Life ◽  
Ig G

FEATURES OF CENTRAL NERVOUS SYSTEM DAMAGE IN CHILDREN WITH CONGENITAL CYTOMEGALOVIRUS INFECTION Gonchar M., Urivaeva М., Muratov G., Malich T., Omelchenko H., Shapko М., LiesnaA., Poliakova V. The paper discusses the features of central nervous system lesions in children with congenital cytomegalovirus infection at different stages of gestation. In the course of the work, an algorithm for diagnosing congenital cytomegalovirus infection was developed. To demonstrate the complexity of diagnosis and treatment in a child of the first year of life, a clinical observation is given. The positive dynamics in the treatment of children with the use of human anticytomegalovirus immunoglobulin with a high content of IgG is discussed. Key words: damage, central nervous system, congenital, young children, anticytomegalovirus.   Резюме ОСОБЛИВОСТІ УРАЖЕННЯ ЦЕНТРАЛЬНОЇ НЕРВОВОЇ СИСТЕМИ У ДІТЕЙЗ ВРОДЖЕНОЮ ЦИТОМЕГАЛОВІРУСНОЮ ІНФЕКЦІЄЮ Гончарь М. О., Уриваєва М. К., Муратов Г. Р., Маліч Т. С., Омельченко О. В., Шапко М. В., Лєсна А. С., Полякова В.В. У роботі розглядаються особливості ураження центральної нервової системи у дітей з вродженою цитомегаловірусною інфекцією на різних термінах гестації. В ході роботи був розроблений алгоритм діагностики вродженої цитомегаловірусної інфекції. Для демонстрації складності діагностики и лікування у дитини первого року життя наводиться клінічне спостереження. Також обговорюється позитивна динаміка в лікуванні дітей при застосуванны антіцітомегаловірусного імуноглобуліна людини з підвіщенім вмістом Ig G. Ключові слова: ураження, центральна нервова система, вроджена, діти раннього віку, антицитомегаловірусний.   Резюме ОСОБЕННОСТИ ПОРАЖЕНИЯ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ У ДЕТЕЙ С ВРОЖДЕННОЙ ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИЕЙ Гончарь М. А., Урываева М. К., Муратов Г. Р., Малич Т. Б., Омельченко Е. В.,Шапко М. В., Лесная А. С., Полякова В.В. В работе рассматриваются особенности поражений центральной нервной системы у детей с врожденной цитомегаловирусной инфекцией на разных сроках гестации. В ходе работы был разработан алгоритм диагностики врожденной цитомегаловирусной инфекции. Для демонстрации сложности диагностики и лечения у ребенка первого года жизни приводится клиническое наблюдение. Обсуждается положительная динамика в лечении детей при применении антицитомегаловирусного иммуноглобулина человека с повышенным содержанием Ig G.  Ключевые слова: поражение, центральная нервная система, врождённая, дети раннего возраста, антицитомегаловирусный.

Mechanisms of injury to the central nervous system following experimental cytomegalovirus infection

1990 ◽  
Vol 11 (5) ◽  
pp. 313-317 ◽  
Author(s):  
John Booss ◽  
Pamela R. Dann ◽  
Susan R. Winkler ◽  
Brigitte P. Griffith ◽  
Jung H. Kim
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cytomegalovirus Infection ◽  
The Central Nervous System

scholarly journals Evaluation of a Commercial PCR Kit for Diagnosis of Cytomegalovirus Infection of the Central Nervous System

1998 ◽  
Vol 36 (11) ◽  
pp. 3382-3384 ◽  
Author(s):  
Adriana Weinberg ◽  
Debbie Spiers ◽  
Guan-Yung Cai ◽  
Christopher M. Long ◽  
Rita Sun ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Sensitivity And Specificity ◽  
Clinical Setting ◽  
Cytomegalovirus Infection ◽  
The Central Nervous System ◽  
Pcr Method

We evaluated the AMPLICOR cytomegalovirus (CMV) PCR kit for the diagnosis of neurologic CMV infections on 43 positive and 112 negative archived cerebrospinal fluid specimens originally tested by an in-house PCR method. The AMPLICOR kit showed sensitivity and specificity of 95 and 100%, respectively, versus the home-grown assay, indicating its utility in this clinical setting.

scholarly journals Meckel-Gruber syndrome: Report of two cases

2012 ◽  
Vol 03 (01) ◽  
pp. 56-59 ◽  
Author(s):  
C. Panduranga ◽  
Ranjit Kangle ◽  
Rajshree Badami ◽  
Prakash V Patil
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autosomal Recessive ◽  
Renal Cysts ◽  
Autosomal Recessive Disorder ◽  
Finnish Population ◽  
Developmental Anomalies ◽  
Rare Syndrome ◽  
The Central Nervous System ◽  
Syndrome Report

ABSTRACTMeckel-Gruber syndrome (MKS) is an autosomal recessive disorder, characterized by a combination of renal cysts and variably associated with features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia, cysts, and polydactyly. It is a rare syndrome with highest incidence in Gujarati Indians and Finnish population. We report two such cases of MKS in non-Gujarati Indian which were diagnosed by neonatal autopsy.

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