Mesenteric fat thickness is associated with metabolic syndrome independently of Apnoea-Hypopnoea Index in subjects with obstructive sleep apnoea

Background: Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) related cardiovascular and metabolic risk factors such as hypertension, diabetes mellitus and dyslipidaemia which together are commonly known as metabolic syndrome (MS) is often overlooked in pregnancy. OSAHS is known to cause higher maternal morbidity and bad foetal outcome. Aim was to study the prevalence of components of MS among third trimester pregnant women with OSAHS.Methods: A total of 100 cases and 100 controls each amongst third trimester pregnant females admitted in the Department of Obstetrics and Gynecology at the Government Medical College, Kozhikode, Kerala, India were enrolled in the study. All subjects underwent a thorough clinical, anthropometric, obstetrical examination and biochemical tests such as complete blood count, blood sugar and lipid profile. The parameters were compared between cases and controls.Results: OSAHS positive pregnant women had a higher prevalence of elevated systolic (P=0.01) and diastolic (P=0.002) blood pressure, abnormal fasting (P<0.0001) and post prandial (P=0.02) blood sugar, abnormal cholesterol (P=0.006) and triglyceride levels (P<0.001), and abnormally low HDL levels (P<0.001).Conclusions: This study showed that metabolic syndrome was highly prevalent among OSAHS positive third trimester pregnancy (52%) versus OSAHS negative (8%) pregnant women.

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Prevalence of metabolic syndrome in a north Indian hospital-based population with obstructive sleep apnoea

The Indian Journal of Medical Research ◽

10.4103/0971-5916.90988 ◽

2011 ◽

Vol 134 (5) ◽

pp. 639 ◽

Cited By ~ 13

Author(s):

SurendraK Sharma ◽

Ramakrishnan Lakshmy ◽

Swastik Agrawal ◽

Vishnubhatla Sreenivas

Keyword(s):

Metabolic Syndrome ◽

Obstructive Sleep Apnoea ◽

Sleep Apnoea ◽

Obstructive Sleep

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Effects of CPAP therapy on visceral fat thickness, carotid intima-media thickness and adipokines in patients with obstructive sleep apnoea

Respirology ◽

10.1111/resp.12963 ◽

2016 ◽

Vol 22 (4) ◽

pp. 786-792 ◽

Cited By ~ 10

Author(s):

Susanna S.S. Ng ◽

Eric K.H. Liu ◽

Ronald C.W. Ma ◽

Tat-On Chan ◽

Kin-Wang To ◽

...

Keyword(s):

Obstructive Sleep Apnoea ◽

Visceral Fat ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Sleep Apnoea ◽

Cpap Therapy ◽

Media Thickness ◽

Obstructive Sleep ◽

Fat Thickness

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Sleeping Beauty or the Beast? – The Metabolic Syndrome from an Obstructive Sleep Apnoea Perspective

European Endocrinology ◽

10.17925/ee.2013.09.01.12 ◽

2010 ◽

Vol 9 (1) ◽

pp. 12 ◽

Cited By ~ 1

Author(s):

Lise Tarnow ◽

Brigitte Klinkenbijl ◽

Holger Woehrle ◽

◽

...

Keyword(s):

Heart Failure ◽

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Obstructive Sleep Apnoea ◽

Reduce Blood Pressure ◽

Sleep Apnoea ◽

Sleeping Beauty ◽

The Metabolic Syndrome ◽

Home Based ◽

Obstructive Sleep

Obstructive sleep apnoea (OSA) is a significant health issue. Patients with cardiovascular disease as well as patients with diabetes have a high prevalence of OSA, and the prevalence of coronary heart disease, heart failure, stroke and diabetes is increased in patients with obstructive sleep apnoea. Physiological responses to OSA include sympathetic activation, neurohumoral changes and inflammation, all of which are precursors for cardiovascular disease and diabetes. International guidelines are starting to recognise the importance of OSA for patients with cardiovascular conditions such as heart failure and hypertension. Diagnosis is important, and home-based sleep testing devices can facilitate this process. Treating OSA with continuous positive airway pressure (CPAP) has been shown to reduce blood pressure (BP) in patients with hypertension, but more research is needed to determine which components of the metabolic syndrome respond best to the addition of CPAP therapy.

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Abstract 5430: Obstructive Sleep Apnoea Exacerbates Muscular Sympathetic Nervous Activity in Patients with Metabolic Syndrome

Circulation ◽

10.1161/circ.118.suppl_18.s_549-a ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Ivani C Trombetta ◽

Cristiane M Nunes ◽

Luciano F Drager ◽

Raffael F Fraga ◽

Maria Janieire N Alves ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Heart Rate ◽

Oxygen Saturation ◽

Obstructive Sleep Apnoea ◽

Nervous Activity ◽

Sleep Apnoea ◽

Sympathetic Nervous Activity ◽

Obstructive Sleep ◽

Sympathetic Nervous

Obstructive sleep apnoea (OSA) and metabolic syndrome (MetS) independently increases muscular sympathetic nervous activity (MSNA). Unknown is whether OSA has an additive effect on MSNA in patients with MetS. We tested the hypothesis that: OSA would have an additive effect on MSNA in patients with MetS. In addition, we studied whether the increase in MSNA in patients with MetS is associated with alteration in arterial baroreflex sensitivity (BRS). Twenty four patients with MetS diagnosed according ATP-III were divided in two groups: MetS+OSA (n=14) and MetS (n=10). They were matched for age, body mass index, waist circumference, and metabolic profile: OSA was defined by an apnoea/hypopnoea index (AHI)>15 events/hour by polysonography. MSNA was recorded directly from the peroneal nerve using the technique of microneurography. Blood pressure (BP) was monitored on a beat-by-beat basis (Finapress) and heart rate by ECG. BRS was analyzed by spontaneous BP and heart rate fluctuations. AHI was higher (42±9 vs. 7±1 events/h, P =0.0001) and minimum oxygen saturation lower (77±2 vs. 87±1 %, P =0.001) in MetS+OSA patients. Patients MetS+OSA had higher MSNA (55±3 vs. 43±2 bursts/100 beats, P =0.01) and systolic BP (158±4 vs.144±3 mmHg, P =0.01) when compared with patients with MetS without OSA. Further analysis showed that AHI and minimum oxygen saturation have significant correlation with MSNA (r=0.65; P =0.001 and r=−0.48; P =0.017, respectively). Patients with MetS+OSA had lower BRS for increases (7.8±0.9 vs. 13.4 ± 1.4 msec/mmHg, P =0.01) and decreases (7.2±0.9 vs. 13.2 ± 2.0 msec/mmHg, P =0.03) in blood pressure than patients with MetS without OSA. MSNA significantly correlated with BRS during spontaneous increases in blood pressure (r=−0.56, P =0.01). OSA exacerbates MSNA in patients with MetS. In addition, the augmented MSNA in patients with MetS+OSA is associated with reduced BRS. These findings suggest that OSA increases the risk for cardiovascular disease in patients with MetS.

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