PREDICTIVE DIAGNOSTIC YIELD OF FLEXIBLE BRONCHOSCOPY FOR CENTRAL LESIONS

Background: Reaching a correct diagnosis is a challenge for physicians treating any of the 30% to 50% of pulmonary tuberculosis patients who have negative sputum cultures or who present with no sputum. Flexible bronchoscopy acquires special importance for these cases for whom empirical anti-tuberculosis therapy is the only option left. In our study we aimed to assess the diagnostic yield of flexible bronchoscopy in patients, suspected to have tuberculosis, whose sputum smears were negative. Methodology: In our hospital-based cross-sectional study, 42 patients were enrolled by consecutive sampling. Flexible bronchoscopy and selective bronchial washings were done in all patients. Results: Bronchoscopy lavage smears were positive for M. tuberculosis in 10 (23.8%) patients. Fifteen (35.7%) patients had positive culture. Conclusion: Flexible bronchoscopy has an important role in the diagnosis of patients suspected to have tuberculosis, whose sputum smears are negative or who can not produce sputum.

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Trans-nasal flexible bronchoscopy in wheezing children: Diagnostic yield, impact on therapy, and prevalence of laryngeal cleft

Pediatric Pulmonology ◽

10.1002/ppul.23829 ◽

2017 ◽

Vol 53 (3) ◽

pp. 310-315 ◽

Cited By ~ 12

Author(s):

Richard P. Boesch ◽

Julie M. Baughn ◽

Shelagh A. Cofer ◽

Karthik Balakrishnan

Keyword(s):

Diagnostic Yield ◽

Flexible Bronchoscopy ◽

Laryngeal Cleft

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Diagnostic yield and safety of flexible bronchoscopy for the diagnosis of pulmonary infections in patients with and without haematological malignancies

10.1183/13993003.congress-2019.pa4555 ◽

2019 ◽

Author(s):

Tobias Mueller ◽

Kai Von Schwanewede ◽

Michael Dreher

Keyword(s):

Diagnostic Yield ◽

Flexible Bronchoscopy ◽

Haematological Malignancies ◽

Pulmonary Infections

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Factors Related to the Diagnostic Yield of Flexible Bronchoscopy without Guidance in Bronchoscopically Invisible Peripheral Lung Lesions

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.2017.80.3.284 ◽

2017 ◽

Vol 80 (3) ◽

pp. 284 ◽

Cited By ~ 1

Author(s):

Hye Seon Kang ◽

Jick Hwan Ha ◽

Hyeon Hui Kang ◽

Chang Dong Yeo ◽

Chin Kook Rhee ◽

...

Keyword(s):

Diagnostic Yield ◽

Flexible Bronchoscopy ◽

Lung Lesions ◽

Peripheral Lung

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Diagnosis of Peripheral Lung Lesions via Conventional Flexible Bronchoscopy with Multiplanar CT Planning

Pulmonary Medicine ◽

10.1155/2016/5048961 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Marianne Anastasia De Roza ◽

Kien Hong Quah ◽

Cheong Kiat Tay ◽

Weiquan Toh ◽

HuiHua Li ◽

...

Keyword(s):

Patient Selection ◽

Diagnostic Yield ◽

Case Series ◽

Flexible Bronchoscopy ◽

Surgical Biopsy ◽

Serious Adverse Events ◽

Ct Guided ◽

Lung Lesions ◽

Peripheral Lung ◽

The Impact

Background. Conventional flexible bronchoscopy has limited sensitivity in the diagnosis of peripheral lung lesions and is dependent on lesion size. However, advancement of CT imaging offers multiplanar reconstruction facilitating enhanced preprocedure planning. This study aims to report efficacy and safety while considering the impact of patient selection and multiplanar CT planning. Method. Prospective case series of patients with peripheral lung lesions suspected of having lung cancer who underwent flexible bronchoscopy (forceps biopsy and lavage). Endobronchial lesions were excluded. Patients with negative results underwent CT-guided transthoracic needle aspiration, surgical biopsy, or clinical-radiological surveillance to establish the final diagnosis. Results. 226 patients were analysed. The diagnostic yield of bronchoscopy was 80.1% (181/226) with a sensitivity of 84.2% and specificity of 100%. In patients with a positive CT-Bronchus sign, the diagnostic yield was 82.4% compared to 72.8% with negative CT-Bronchus sign (p=0.116). Diagnostic yield was 84.9% in lesions > 20 mm and 63.0% in lesions ≤ 20 mm (p=0.001). Six (2.7%) patients had transient hypoxia and 2 (0.9%) had pneumothorax. There were no serious adverse events. Conclusion. Flexible bronchoscopy with appropriate patient selection and preprocedure planning is more efficacious in obtaining a diagnosis in peripheral lung lesions compared to historical data. This trial is registered with ClinicalTrials.gov Identifier: NCT01374542.

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