scholarly journals A Simple Toxicokinetic Model Exhibiting Complex Dynamics and Nonlinear Exposure Response

Risk Analysis ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 2561-2571
Author(s):  
Robert M. Park
Keyword(s):  
Complex Dynamics ◽  
Exposure Response ◽  
Toxicokinetic Model

scholarly journals Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Alan F. Sasso ◽  
Panos G. Georgopoulos ◽  
Sastry S. Isukapalli ◽  
Kannan Krishnan
Keyword(s):  
Bayesian Analysis ◽  
Internal Exposure ◽  
Lipophilic Compounds ◽  
Exposure Response ◽  
Physiologically Based ◽  
Tissue Lipids ◽  
Toxicokinetic Model ◽  
High Doses ◽  
Induction Model

A lipid-based physiologically based toxicokinetic (PBTK) model has been developed for a mixture of six polychlorinated biphenyls (PCBs) in rats. The aim of this study was to apply population Bayesian analysis to a lipid PBTK model, while incorporating an internal exposure-response model linking enzyme induction and metabolic rate. Lipid-based physiologically based toxicokinetic models are a subset of PBTK models that can simulate concentrations of highly lipophilic compounds in tissue lipids, without the need for partition coefficients. A hierarchical treatment of population metabolic parameters and a CYP450 induction model were incorporated into the lipid-based PBTK framework, and Markov-Chain Monte Carlo was applied toin vivodata. A mass balance of CYP1A and CYP2B in the liver was necessary to model PCB metabolism at high doses. The linked PBTK/induction model remained on a lipid basis and was capable of modeling PCB concentrations in multiple tissues for all dose levels and dose profiles.

Complex Dynamics at Work: OD Theory and Practice

2005 ◽  
Author(s):  
Glenda Eoyang
Keyword(s):  
Complex Dynamics ◽  
Theory And Practice

Frontiers in Complex Dynamics

2014 ◽  
Author(s):  
Araceli Bonifant ◽  
Misha Lyubich ◽  
Scott Sutherland
Keyword(s):  
Historical Perspective ◽  
Complex Dynamics ◽  
Short Paper ◽  
Combinatorial Group Theory ◽  
Entropy Theory ◽  
Holomorphic Dynamics ◽  
Eightieth Birthday ◽  
Several Variables ◽  
Fields Medal ◽  
Combinatorial Group

John Milnor, best known for his work in differential topology, K-theory, and dynamical systems, is one of only three mathematicians to have won the Fields medal, the Abel prize, and the Wolf prize, and is the only one to have received all three of the Leroy P. Steele prizes. In honor of his eightieth birthday, this book gathers together surveys and papers inspired by Milnor's work, from distinguished experts examining not only holomorphic dynamics in one and several variables, but also differential geometry, entropy theory, and combinatorial group theory. The book contains the last paper written by William Thurston, as well as a short paper by John Milnor himself. Introductory sections put the papers in mathematical and historical perspective, color figures are included, and an index facilitates browsing.

An Alternative Approach To User Fee Policy In The Primary Health Care Setting Of Bangladesh.

2020 ◽  
Author(s):  
Nazneen Akhter
Keyword(s):  
Health Care ◽  
Primary Health Care ◽  
Complex Dynamics ◽  
Quality Care ◽  
Secondary Data ◽  
User Fees ◽  
Primary Health ◽  
Alternative Approach ◽  
Benefit Principle ◽  
User Fee

The concept of ascribing user fee in health care settings always remained a policy struggle and countries experienced different learning in this regards while implementing user fee at different tiers of health settings. The most exquisite learning among the many country specific evidences related to user fee are the match and mismatch between the equity principle and benefit principle while considering the client perspective. There is an added dimension of quality care which also add more complex dynamics into this concept since the quality care consideration has a double edged perspective both for clients and providers, where which one will get superiority over whom is a great question in health care, especially in the Primary Health care (PHC) of the country. In this reality the appropriate implementation guideline, followed by an appropriate practice of the administrative and management both service oriented and financial are of great importance in this user fee implementation consideration which always remained a challenge in the health care specially in remote care of PHC. This paper attempted a secondary data searching and scoping the available documents of Bangladesh and across the world to find an alternative approach to user fees policy where equity and benefit principle and quality - these three have to be placed in a well-constructed triad in PHC implementation which has been recommended as an alternative policy imperative in approaching user fees for Bangladesh PHC settings.

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