Many novel diseases are of zoonotic origin, likely including COVID-19. Describing diseases as originating from diverse exotic animals can increase risk perceptions and protective avoidance behaviors, but may also activate stereotypes, increasing discriminatory behaviors and disease stigma. Data from the first several weeks of the US COVID-19 pandemic tested how communications about zoonotic disease origins affect people’s risk perceptions, health behaviors, and stigma. Participants (N = 677) who read news articles describing exotic animals (e.g., snakes) as sources of COVID-19 viewed the virus as riskier and reported stronger intentions to engage in preventative behaviors (e.g., handwashing), relative to those who read about a familiar source (pigs). Reading exotic origin descriptions was associated with stronger intentions to avoid Asian individuals and animal products, both of which contributed to greater stigma for COVID-19. Results have implications for public health communicators who aim to increase risk perceptions without activating stigma or prejudice.