scholarly journals Does type 1 diabetes alter post-exercise thermoregulatory and cardiovascular function in young adults?

2014 ◽  
Vol 25 (5) ◽  
pp. e504-e514 ◽  
Author(s):  
R. McGinn ◽  
M. R. Carter ◽  
J. Barrera-Ramirez ◽  
R. J. Sigal ◽  
A. D. Flouris ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Cardiovascular Function ◽  
Post Exercise

Alterations in Skeletal Muscle Repair in Young Adults with Type 1 Diabetes Mellitus

2021 ◽  
Author(s):  
Athan G. Dial ◽  
Grace K. Grafham ◽  
Cynthia MF. Monaco ◽  
Jennifer Voth ◽  
Linda Brandt ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Skeletal Muscle ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Gene Networks ◽  
Vastus Lateralis ◽  
Post Exercise ◽  
Ultrastructural Damage ◽  
The Impact

Though preclinical models of type 1 diabetes (T1D) exhibit impaired muscle regeneration, this has yet to be investigated in humans with T1D. Here we investigated the impact of damaging exercise (eccentric quadriceps contractions) in eighteen physically-active young adults with and without T1D. Pre- and post-exercise (48h and 96h), participants provided blood samples, vastus lateralis biopsies and performed maximal voluntary quadriceps contractions (MVC). Skeletal muscle sarcolemmal integrity, extracellular matrix content (ECM), and satellite cell (SC) content/proliferation were assessed by immunofluorescence. Transmission electron microscopy was used to quantify ultrastructural damage. MVC was comparable between T1D and controls before exercise. Post-exercise, MVC was decreased in both groups, but T1D subjects exhibited moderately lower strength recovery at both 48h and 96h. Serum creatine kinase, an indicator of muscle damage, was moderately higher in T1D participants at rest, and exhibited a small elevation 96h post-exercise. T1D participants showed lower SC content at all timepoints and demonstrated a moderate delay in SC proliferation after exercise. A greater number of myofibers exhibited sarcolemmal damage (disrupted dystrophin) and increased ECM (laminin) content in participants with T1D despite no differences between groups in ultrastructural damage as assessed by electron microscopy. Finally, transcriptomic analyses revealed dysregulated gene networks involving RNA translation and mitochondrial respiration, providing potential explanations for previous observations of mitochondrial dysfunction in similar T1D cohorts. Our findings indicate that skeletal muscle in young adults with moderately-controlled T1D is altered after damaging exercise; suggesting that longer recovery times following intense exercise may be necessary.

Assessment of the prevalence of type 1 diabetes microvascular complications in young adults in the repablic of Belarus with regard to the duration of the disease

2017 ◽  
Author(s):  
Yuliya Dydyshka ◽  
Alla Shepelkevich ◽  
Vladislav Yurkovets ◽  
Elena Brutskaya-Stempkovskaya ◽  
Marina Mantachik
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications

Optimal Insulin Correction Factor (ICF) for Post-exercise Hyperglycemia following High-Intensity Training in Adults with Type 1 Diabetes (T1D)—The FIT Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 732-P ◽  
Author(s):  
RONNIE ARONSON ◽  
RUTH E. BROWN ◽  
MICHAEL RIDDELL
Keyword(s):  
Type 1 Diabetes ◽  
Correction Factor ◽  
High Intensity ◽  
Post Exercise ◽  
High Intensity Training ◽  
Intensity Training

466-P: Effect of Metformin on Cardiovascular Function in Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 466-P
Author(s):  
JOSHUA ABOLARIN ◽  
IRENE E. SCHAUER
Keyword(s):  
Type 1 Diabetes ◽  
Cardiovascular Function

805-P: Barriers and Facilitators of Participation in Clinical Trials among Youth and Young Adults with Type 1 Diabetes and Their Caregivers

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 805-P
Author(s):  
SARAH C. WESTEN ◽  
LINDSAY M. ANDERSON ◽  
SAMANTHA A. BARRY ◽  
SYDNEY LOOK ◽  
STEFANIA PINTO ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Barriers And Facilitators ◽  
Youth And Young Adults

803-P: Modifiable Diabetes-Specific Factors and Glycemic Control in Economically Vulnerable and Racial/Ethnic Minority Young Adults with Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 803-P
Author(s):  
SHIVANI AGARWAL ◽  
LAUREN KANAPKA ◽  
JENNIFER RAYMOND ◽  
ASHBY F. WALKER ◽  
ANDREA GERARD GONZALEZ ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Glycemic Control ◽  
Ethnic Minority ◽  
Specific Factors ◽  
Racial Ethnic

898-P: Benefit of Continuous Glucose Monitoring (CGM) in Reducing Hemoglobin A1c Is Sustained through 12 Months of Use among Adolescents and Young Adults with Type 1 Diabetes (T1D)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 898-P
Author(s):  
KELLEE MILLER ◽  
LAUREN KANAPKA ◽  
COLLEEN BAUZA ◽  
LORI M. LAFFEL
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Continuous Glucose Monitoring ◽  
Hemoglobin A1c ◽  
Glucose Monitoring ◽  
Adolescents And Young Adults

890-P: Durability of Continuous Glucose Monitoring (CGM) Use in Young Children, Teens, and Young Adults with Type 1 Diabetes (T1D)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 890-P
Author(s):  
DANIEL DESALVO ◽  
LAUREN KANAPKA ◽  
COLLEEN BAUZA ◽  
CICILYN XIE ◽  
LINDA DIMEGLIO ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Young Children ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring
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