scholarly journals Vasomotion analysis of speed resolved perfusion, oxygen saturation, red blood cell tissue fraction, and vessel diameter: Novel microvascular perspectives

2021 ◽  
Author(s):  
Ingemar Fredriksson ◽  
Marcus Larsson ◽  
Tomas Strömberg ◽  
Fredrik Iredahl
Keyword(s):  
Blood Cell ◽  
Oxygen Saturation ◽  
Red Blood Cell ◽  
Vessel Diameter ◽  
Cell Tissue ◽  
Tissue Fraction

scholarly journals Oxygen saturation, red blood cell tissue fraction and speed resolved perfusion — A new optical method for microcirculatory assessment

2015 ◽  
Vol 102 ◽  
pp. 70-77 ◽  
Author(s):  
Hanna Jonasson ◽  
Ingemar Fredriksson ◽  
Anders Pettersson ◽  
Marcus Larsson ◽  
Tomas Strömberg
Keyword(s):  
Blood Cell ◽  
Oxygen Saturation ◽  
Red Blood Cell ◽  
Optical Method ◽  
Cell Tissue ◽  
Tissue Fraction

Oxygen exchange in the microcirculation of hamster retractor muscle

1989 ◽  
Vol 256 (1) ◽  
pp. H247-H255 ◽  
Author(s):  
D. P. Swain ◽  
R. N. Pittman
Keyword(s):  
Blood Cell ◽  
Oxygen Saturation ◽  
Oxygen Tension ◽  
Red Blood Cell ◽  
Unit Length ◽  
Retractor Muscle ◽  
Tissue Oxygen ◽  
Hemoglobin Oxygen Saturation ◽  
First Order ◽  
Weighted Values

We determined percent hemoglobin oxygen saturation (SO2) in arterioles and venules of the hamster retractor muscle at rest. We found that SO2 decreased from 69.9 +/- 1.4% (SE) in large input arterioles (first order, 1A, ID = 60 +/- 3 micron) to flow-weighted values of 56.7% in small arterioles (4A, ID = 20 +/- 1 micron), 51.3% in small venules (4V, ID = 28 +/- 1 micron), and to 50.6 +/- 1.0% in large venules (1V, ID = 147 +/- 13 micron). Thus approximately two-thirds of the net decline in SO2 for this tissue occurred by diffusion of oxygen from arterioles, whereas only about one-third occurred by diffusion from capillaries. Furthermore, no net shunting of oxygen from the arterioles to the venules was detected as evidenced by the absence of any significant change in venular SO2. By determining the SO2 at upstream and downstream ends of arterioles in four consecutive branching orders (1A-4A), we found that the decrease in SO2 per unit length (delta SO2/L) increased approximately 20-fold from 1A to 4A. This increase in delta SO2/L was directly proportional to estimated luminal minus tissue oxygen tension and inversely proportional to red blood cell flow.

Adaptation to intermittent hypoxia: dynamics of blood oxygen saturation and some hematological parameters

2020 ◽  
Author(s):  
VP Katuntsev ◽  
SYu Zakharov ◽  
TV Sukhostavtseva ◽  
AA Puchkova
Keyword(s):  
Blood Cell ◽  
Oxygen Saturation ◽  
Cell Count ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Reticulocyte Count ◽  
Blood Oxygen ◽  
Blood Cell Count ◽  
Blood Oxygen Saturation ◽  
Red Blood Cell Count

Adaptation to hypoxia is an important object of medical research. The aim of this study was to investigate the dynamics of blood oxygen saturation (SpO2), arterial blood pressure (BP), red blood cells, reticulocytes, hemoglobin and erythropoietin (EPO) concentrations during intermittent hypoxic training (IHT). The study was conducted in 11 healthy male volunteers; 2 regimens were tested: 11 and 14 days of IHT at FIO2 = 9%. Exposure to the hypoxic gas mixture caused a reduction in SpO2 by an average of 20.4% (p < 0.05), a 22% increase in the heart rate (p < 0.05) and a 4.5% decrease in diastolic BP (p < 0.05) relative to the initial levels. After 11 days of IHT training, the reticulocyte count was increased by 16.6% (p < 0.05), and there was a distinct tendency to elevated red blood cells (p > 0.05) and hemoglobin (p > 0.05). EPO concentrations declined by 44.2% (p < 0.05) relative to the initial level. Extending the regimen to 14 days resulted in a 3.9% increase in red blood cell count (p < 0.05) and a 4.7% elevation of hemoglobin concentrations (p < 0.05), accompanied by the recovery of the initial reticulocyte count. The applied 2-week IHT regimen resulted in the increased red blood cell count and elevated hemoglobin, suggesting an improvement in the oxygen-carrying capacity of the blood. The proposed regimen can be used to improve physical performance of individuals working in extreme environmental conditions.

Red blood cell regulation of microvascular tone through adenosine triphosphate

2000 ◽  
Vol 278 (4) ◽  
pp. H1294-H1298 ◽  
Author(s):  
Hans H. Dietrich ◽  
Mary L. Ellsworth ◽  
Randy S. Sprague ◽  
Ralph G. Dacey
Keyword(s):  
Blood Flow ◽  
Blood Cell ◽  
Red Blood Cells ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Tissue Perfusion ◽  
Vessel Diameter ◽  
Flow Regulation ◽  
Vascular Control ◽  
Cerebral Arterioles

The matching of blood flow with metabolic need requires a mechanism for sensing the needs of the tissue and communicating that need to the arterioles, the ultimate controllers of tissue perfusion. Despite significant strides in our understanding of blood flow regulation, the identity of the O2 sensor has remained elusive. Recently, the red blood cell, the Hb-containing O2carrier, has been implicated as a potential O2 sensor and contributor to this vascular control by virtue of its concomitant carriage of millimolar amounts of ATP, which it is able to release when exposed to a low-O2 environment. To evaluate this possibility, we exposed perfused cerebral arterioles to low extraluminal O2 in the absence and presence of red blood cells or 6% dextran and determined both vessel diameter and ATP in the vessel effluent. Only when the vessels were perfused with red blood cells did the vessels dilate in response to low extraluminal O2. In addition, this response was accompanied by a significant increase in vessel effluent ATP. These findings support the hypothesis that the red blood cell itself serves a role in determining O2 supply to tissue.

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