Adaptation to intermittent hypoxia: dynamics of blood oxygen saturation and some hematological parameters

2020 ◽  
Author(s):  
VP Katuntsev ◽  
SYu Zakharov ◽  
TV Sukhostavtseva ◽  
AA Puchkova
Keyword(s):  
Blood Cell ◽  
Oxygen Saturation ◽  
Cell Count ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Reticulocyte Count ◽  
Blood Oxygen ◽  
Blood Cell Count ◽  
Blood Oxygen Saturation ◽  
Red Blood Cell Count

Adaptation to hypoxia is an important object of medical research. The aim of this study was to investigate the dynamics of blood oxygen saturation (SpO2), arterial blood pressure (BP), red blood cells, reticulocytes, hemoglobin and erythropoietin (EPO) concentrations during intermittent hypoxic training (IHT). The study was conducted in 11 healthy male volunteers; 2 regimens were tested: 11 and 14 days of IHT at FIO2 = 9%. Exposure to the hypoxic gas mixture caused a reduction in SpO2 by an average of 20.4% (p < 0.05), a 22% increase in the heart rate (p < 0.05) and a 4.5% decrease in diastolic BP (p < 0.05) relative to the initial levels. After 11 days of IHT training, the reticulocyte count was increased by 16.6% (p < 0.05), and there was a distinct tendency to elevated red blood cells (p > 0.05) and hemoglobin (p > 0.05). EPO concentrations declined by 44.2% (p < 0.05) relative to the initial level. Extending the regimen to 14 days resulted in a 3.9% increase in red blood cell count (p < 0.05) and a 4.7% elevation of hemoglobin concentrations (p < 0.05), accompanied by the recovery of the initial reticulocyte count. The applied 2-week IHT regimen resulted in the increased red blood cell count and elevated hemoglobin, suggesting an improvement in the oxygen-carrying capacity of the blood. The proposed regimen can be used to improve physical performance of individuals working in extreme environmental conditions.

scholarly journals Anemia dan Lama Konsumsi Obat Anti Tuberculosis

2017 ◽  
Vol 3 (2) ◽  
pp. 42
Author(s):  
Anny Thuraidah ◽  
Rima Agnes Widya Astuti ◽  
Dinna Rakhmina
Keyword(s):  
Infectious Disease ◽  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Blood Cell Count ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Red Blood Cell Count ◽  
Cross Sectional Design

<p style="text-align: justify;">Tuberculosis is an infectious disease due to Mycobacterium tuberculosis germ that can infect several organs, including the lungs, kidneys, and bones. The goal of treatment of tuberculosis is tuberculosis bacilli destroy quickly and prevent recurrence. First category treatment of tuberculosis is isoniazid, rifampin, streptomycin, ethambutol, and pyrazinamide. Although the most anti-tuberculosis drug is acceptable in therapy, but have potentially toxic effects hematologic reactions such as agranulocytosis, eosinophilia, thrombocytopenia, and anemia. This research aims to know the correlation between anti-tuberculosis drug consumption in pulmonary TB patients against anemia. Method of this research was Analytical Survey with a Cross-Sectional design. The average results of red blood cell count for 0 months 5,16 106/uL, 2 months 4,39 106/uL and 6 months 4,61 106/uL, haemoglobin levels for 0 month 15,17 g/dL, 2 months 12,73 g/dL and 6 months 13,28 g/dL as well as hematocrit value for 0 month 44,26 %, 2 months 38,24 % and 6 months 39,04 %. From Spearman statistics analytical was obtained significant of red blood cell count 0.004 &lt; α (0.05), levels of hemoglobin 0.007 &lt; α (0.05) and the value of hematocrit 0.015 &lt; α (0.05), it was concluded there was correlation between long consumption of anti-tuberculosis drug with anemia and the value of the correlation coefficient count of red blood cells -0.531, levels of hemoglobin-0.479 as well as the value of hematocrit -0.440 means has the power correlations are medium. Further research is recommended to use different parameters such as the number of platelets, AST/ALT levels and should use the same patient sample or from 0 months up to 6 months </p>

scholarly journals Effect of plateletpheresis on hematocrit, hemoglobin and erythrocyte count: Meta-analysis 1980–2018

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alejandro Gil-Betacur ◽  
Carmen Yulieth Mantilla-Gutiérrez ◽  
Jaiberth Antonio Cardona-Arias
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Erythrocyte Count ◽  
Blood Cell Count ◽  
Selection Processes ◽  
Negative Effect ◽  
Red Blood Cell Count ◽  
The Mean

AbstractThe effects of platelet donation by apheresis on different parameters of the erythrogram are still unclear. The objective was to meta-analyze the effect of plateletpheresis on hematocrit, hemoglobin, and erythrocyte count, with a systematic review with random effects meta-analysis of the mean difference. The PRISMA guidelines were considered, as well as 133 search strategies on four different databases. Reproducibility was guaranteed and methodological quality was evaluated. Heterogeneity was evaluated with Galbraith and DerSimonian-Laird’s, publication bias with a funnel plot and a Begg’s test, sensitivity analysis and a cumulative meta-analysis were also conducted. Eighteen (18) articles were included, 17 evaluated the effects on hematocrit in 2,564 donors; 13 on hemoglobin in 1,640 donors; and 4 on red blood cell count in 243 donors. A decrease of 2.26% (CI95% = 2.11–2.41) was observed in hematocrit, of 0.80 g/dL (CI95% = 0.75–0.86) in hemoglobin and −0.21 × 1012/L (CI95% = −0.13; −0.29) in red blood cell count. Plateletpheresis has a negative effect on the erythrogram parameters, explained by blood loss in the kits used for the procedure and cell lysis. Such evidence is relevant to secure the efficiency and safety of the procedure, improve selection processes or determine the number of donations that can be performed without affecting donors’ health.

Red blood cell count in short-term prediction of cardiovascular disease incidence in the Gubbio population Study

2002 ◽  
Vol 57 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Paolo Emilio PUDDU ◽  
Mariapoala LANTI ◽  
Alessandro MENOTTI ◽  
Mario MANCINI ◽  
Alberto ZANCHETTI ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Disease Incidence ◽  
Blood Cell Count ◽  
Short Term ◽  
Red Blood Cell Count ◽  
Short Term Prediction ◽  
Cardiovascular Disease Incidence

scholarly journals A follistatin‐based molecule increases muscle and bone mass without affecting the red blood cell count in mice

2019 ◽  
Vol 33 (5) ◽  
pp. 6001-6010 ◽  
Author(s):  
Andreas Lodberg ◽  
Bram C. J. Eerden ◽  
Bianca Boers‐Sijmons ◽  
Jesper Skovhus Thomsen ◽  
Annemarie Brüel ◽  
...  
Keyword(s):  
Bone Mass ◽  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Blood Cell Count ◽  
Red Blood Cell Count

Blood Parameters in Natural Populations of Trichosurus Species (Marsupialia: Phalangeridae). I. Age, Sex and Seasonal Variation in T. Caninus and T. Vulpecula. Ii. Influence of Habitat and Population Strategies of T. Caninus and T. Vulpecula.

1979 ◽  
Vol 27 (6) ◽  
pp. 913 ◽  
Author(s):  
JL Barnett ◽  
RA How ◽  
WF Humphreys
Keyword(s):  
Body Weight ◽  
Seasonal Variation ◽  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Plasma Glucose ◽  
Haemoglobin Concentration ◽  
Blood Parameters ◽  
Blood Cell Count ◽  
Red Blood Cell Count

Age, sex and seasonal related changes in body weight and blood parameters were determined for T caninus and T. vulpecula, whose distribution overlapped in part of the study area. In T. caninus age-related changes occurred in body weight, mean plasma glucose and protein concentrations and haematocrit. Seasonal changes occurred in plasma glucose and protein concentrations, haemoglobin concentration and red blood cell count. There were sexual dimorphisms in haematocrit, haemoglobin concentration and red blood cell count in both species; the mean values were greater in males. T. vulpecula also exhibited a sexual dimorphism in body weight (males > females). The only seasonal change in T. vulpecula was in haemoglobin concentration. Comparison of the species as adults showed that T. caninus had higher mean levels of body weight, haematocrit and haemoglobin concentration, while plasma lipid concentration and red blood cell counts were greater in T vulpecula. These species differences may be a reflection of the diets of the two species. In addition the measured parameters showed greater seasonal variation in T. caninus, a K-selected species, than in T. vulpecula, which is more r-selected.

scholarly journals The Erythropoetin rs1617640 Gene Polymorphism Associates with Hemoglobin Levels, Hematocrit and Red Blood Cell Count in Patients with Peripheral Arterial Disease

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1305
Author(s):  
Wilfried Renner ◽  
Melanie Kaiser ◽  
Sebastian Khuen ◽  
Olivia Trummer ◽  
Harald Mangge ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Gene Polymorphism ◽  
Blood Cell ◽  
Cell Count ◽  
Red Blood Cell ◽  
Arterial Disease ◽  
Multivariate Linear Regression Analysis ◽  
Blood Cell Count ◽  
Red Blood Cell Count ◽  
Peripheral Arterial

Background: Erythropoietin has a pivotal role in erythropoiesis and angiogenesis. A common polymorphism (rs1617640, A > C) in the promoter of the erythropoietin gene (EPO) has been associated with erythropoietin expression and microvascular complications of diabetes. We aimed to analyze the potential role of this polymorphism in the pathogenesis of peripheral arterial disease (PAD). Methods: EPO genotypes and laboratory markers for erythropoiesis were determined in 945 patients with PAD. Results: The minor EPO rs1617640 C-allele was associated in an allele-dose-dependent manner with hemoglobin levels (p = 0.006), hematocrit (p = 0.029), and red blood cell count (p = 0.003). In a multivariate linear regression analysis including conventional risk factors diabetes, sex, and smoking, EPO genotypes were furthermore associated with age at onset of PAD symptoms (p = 0.009). Conclusions: The EPO rs1617640 gene polymorphism affects erythropoiesis, leads to an earlier onset of PAD, and is a potential biomarker for the pathogenesis of this disease.

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