scholarly journals Development and in vitro/in vivo  evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach

2017 ◽  
Vol 22 (12) ◽  
pp. 1514-1522 ◽  
Author(s):  
Higo Fernando Santos Souza ◽  
Daniel Real ◽  
Darío Leonardi ◽  
Sandra Carla Rocha ◽  
Victoria Alonso ◽  
...  
Keyword(s):  
Dosage Form ◽  
Quality By Design ◽  
Design Approach ◽  
In Vivo Evaluation ◽  
Quality By Design Approach ◽  
Liquid Dosage Form

Potential Mucoadhesive Dosage Form of Lidocaine Hydrochloride: II. In Vitro and In Vivo Evaluation

2007 ◽  
Vol 33 (4) ◽  
pp. 437-448 ◽  
Author(s):  
Rana Abu-Huwaij ◽  
Shereen Assaf ◽  
Mutaz Salem ◽  
Alsayed Sallam
Keyword(s):  
Dosage Form ◽  
Lidocaine Hydrochloride ◽  
In Vivo Evaluation

scholarly journals Future outlook hydrodynamic drug delivery system of solid oral dosage form: Review

2021 ◽  
Vol 6 (3) ◽  
pp. 96-101
Author(s):  
Akhilesh Kumar Singh ◽  
Neeraj Sharma
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Dosage Form ◽  
In Vitro Study ◽  
Local Effect ◽  
Oral Dosage ◽  
In Vivo Evaluation ◽  
Absorption Window

Over the last few years, therapeutic efficacy of drugs that have poor bioavailability or narrow absorption window have challenged the pharmaceutical industry. In this framework, many Hydrodynamic Balance System (HBS) also known as Gastro retentive dosage forms (GRDFs) have been used to enhance the therapeutic efficacy of drugs. Such drug have a narrow absorption window, are unstable at higher pH, are soluble in acidic conditions, and are local effect in the gastric-part. The drug development with recent technology of various novel polymeric-based gastroretentive drug delivery technologies that may regulate the bioavailability and extend time of therapeutic efficacy of such drugs. Our focus on the significance of in vitro study and in vivo evaluation parameters of various HBS drugs along with their applications.  This study provides a promising platform for advantages and guide formulation of HBS dosage form were covered in detail.

scholarly journals Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 154 ◽  
Author(s):  
Eva-Maria Theismann ◽  
Julia K. Keppler ◽  
Martin Owen ◽  
Karin Schwarz ◽  
Walkiria Schlindwein
Keyword(s):  
Process Parameters ◽  
Quality By Design ◽  
Spherical Shape ◽  
Release Profile ◽  
Design Approach ◽  
Quality By Design Approach ◽  
Solid Feed Rate ◽  
Wet Extrusion ◽  
Spray Granulation

The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of the extrusion-spheronisation process on the roundness, roughness and useable yield of the obtained pellets. The obtained results were compared to spray granulated NAM particles regarding their characteristics and their release profile in vitro after the application of an ileocolon targeted shellac coating. The wet extrusion-spheronisation process was able to form highly loaded NAM pellets (80%) with a spherical shape and a high useable yield of about 90%. However, the water content range was rather narrow between 24.7% and 21.3%. The design of experiments (DoE), showed that the spheronisation conditions speed, time and load had a greater impact on the quality attributes of the pellets than the extrusion conditions screw design, screw speed and solid feed rate (hopper speed). The best results were obtained using a low load (15 g) combined with a high rotation speed (900 m/min) and a low time (3–3.5 min). In comparison to spray granulated NAM pellets, the extruded NAM pellets resulted in a higher roughness and a higher useable yield (63% vs. 92%). Finally, the coating and dissolution test showed that the extruded and spheronised pellets are also suitable for a protective coating with an ileocolonic release profile. Due to its lower specific surface area, the required shellac concentration could be reduced while maintaining the release profile.

scholarly journals IN VITRO AND IN VIVO EVALUATION OF THE GASTRORETENTIVE FLOATING DOSAGE FORM

2014 ◽  
Vol 5 (9) ◽  
pp. 695-700 ◽  
Author(s):  
Sarojini Sarangapani ◽  
Jayanthi Bangaru ◽  
Manavalan Rajappan
Keyword(s):  
Dosage Form ◽  
In Vivo Evaluation

A once-a-day dosage form for the delivery of insulin through the nasal route: in vitro assessment and in vivo evaluation

2013 ◽  
Vol 1 (3) ◽  
pp. 306-314 ◽  
Author(s):  
H. Nazar ◽  
P. Caliceti ◽  
B. Carpenter ◽  
A. I. El-Mallah ◽  
D. G. Fatouros ◽  
...  
Keyword(s):  
Dosage Form ◽  
In Vivo Evaluation ◽  
Nasal Route ◽  
In Vitro Assessment
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