IN VITRO AND IN VIVO EVALUATION OF THE GASTRORETENTIVE FLOATING DOSAGE FORM

Over the last few years, therapeutic efficacy of drugs that have poor bioavailability or narrow absorption window have challenged the pharmaceutical industry. In this framework, many Hydrodynamic Balance System (HBS) also known as Gastro retentive dosage forms (GRDFs) have been used to enhance the therapeutic efficacy of drugs. Such drug have a narrow absorption window, are unstable at higher pH, are soluble in acidic conditions, and are local effect in the gastric-part. The drug development with recent technology of various novel polymeric-based gastroretentive drug delivery technologies that may regulate the bioavailability and extend time of therapeutic efficacy of such drugs. Our focus on the significance of in vitro study and in vivo evaluation parameters of various HBS drugs along with their applications. This study provides a promising platform for advantages and guide formulation of HBS dosage form were covered in detail.

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A once-a-day dosage form for the delivery of insulin through the nasal route: in vitro assessment and in vivo evaluation

Biomaterials Science ◽

10.1039/c2bm00132b ◽

2013 ◽

Vol 1 (3) ◽

pp. 306-314 ◽

Cited By ~ 12

Author(s):

H. Nazar ◽

P. Caliceti ◽

B. Carpenter ◽

A. I. El-Mallah ◽

D. G. Fatouros ◽

...

Keyword(s):

Dosage Form ◽

In Vivo Evaluation ◽

Nasal Route ◽

In Vitro Assessment

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In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate

International Journal of Pharmaceutics ◽

10.1016/0378-5173(92)90033-x ◽

1992 ◽

Vol 86 (1) ◽

pp. 79-88 ◽

Cited By ~ 53

Author(s):

A.K. Hilton ◽

P.B. Deasy

Keyword(s):

Sustained Release ◽

Dosage Form ◽

In Vivo Evaluation

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Floating matrix dosage form for phenoporlamine hydrochloride based on gas forming agent: In vitro and in vivo evaluation in healthy volunteers

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2005.12.003 ◽

2006 ◽

Vol 310 (1-2) ◽

pp. 139-145 ◽

Cited By ~ 31

Author(s):

Xiaoqiang Xu ◽

Minjie Sun ◽

Feng Zhi ◽

Yiqiao Hu

Keyword(s):

Healthy Volunteers ◽

Dosage Form ◽

In Vivo Evaluation

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FORMULATION AND IN-VITRO-IN-VIVO EVALUATION OF ALGINATE-CHITOSAN MICROSPHERES OF GLIPIZIDE BY IONIC GELATION METHOD

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i7.18725 ◽

2017 ◽

Vol 10 (7) ◽

pp. 385 ◽

Cited By ~ 1

Author(s):

Maya Sharma ◽

Choudhury Pk ◽

Suresh Kumar Dev

Keyword(s):

Sustained Release ◽

Dosage Form ◽

Oral Dosage ◽

Ionic Gelation ◽

In Vivo Evaluation ◽

Chitosan Microspheres ◽

Model Drug ◽

Effective Use

Objective: The present work is aimed to formulate and evaluate alginate-chitosan microspheres of glipizide for the effective use in the treatment of diabetes.Methods: Sustained release microspheres were prepared by gentle mixing of polymers in water phase with drug by agitation. The polymers used for preparation were sodium alginate and chitosan, which was extruded into 5% calcium chloride solution to produce microspheres by ionic gelation method.Results: Single unit dosage form of Glipizide causes gastric irritation. To convert it in to the multiple unit dosage form will release the drug evenly throughout the stomach which suppresses the irritation. The aim of study towards formulation and evaluation of alginate-chitosan microspheres, which can provide sustained release of the model drug. It shows better in-vitro and in-vivo activity than conventional dosage forms. The work also aims to study various parameters affecting the behavior of microspheres in oral dosage form. Conclusion: Drugs that are simply absorbed from the gastrointestinal tract (GIT) and having a short half life are eliminated rapidly from the blood flow. To avoid this trouble, the oral sustained release (SR) has been developed as these will release the drug slowly in to the GIT and maintain a stable drug concentration in the serum for a longer period of time.

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