scholarly journals Recombination suppression in heterozygotes for a pericentric inversion induces the interchromosomal effect on crossovers in Arabidopsis

2019 ◽  
Vol 100 (6) ◽  
pp. 1163-1175 ◽  
Author(s):  
Pasquale Termolino ◽  
Matthieu Falque ◽  
Riccardo Aiese Cigliano ◽  
Gaetana Cremona ◽  
Rosa Paparo ◽  
...  
Keyword(s):  
Pericentric Inversion ◽  
Recombination Suppression ◽  
Interchromosomal Effect

scholarly journals Interchromosomal effect leading to an increase in aneuploidy in sperm nuclei in a man heterozygous for pericentric inversion (inv 9) and C-heterochromatin

2001 ◽  
Vol 46 (5) ◽  
pp. 245-250 ◽  
Author(s):  
A. Amiel ◽  
F. Sardos-Albertini ◽  
M. D. Fejgin ◽  
R. Sharony ◽  
R. Diukman ◽  
...  
Keyword(s):  
Pericentric Inversion ◽  
Interchromosomal Effect ◽  
Sperm Nuclei

scholarly journals Recombination suppression in heterozygotes for a pericentric inversion induces interchromosomal effect on crossovers in Arabidopsis

2018 ◽  
Author(s):  
Pasquale Termolino ◽  
Matthieu Falque ◽  
Gaetana Cremona ◽  
Rosa Paparo ◽  
Antoine Ederveen ◽  
...  
Keyword(s):  
Pericentric Inversion ◽  
Molecular Mechanisms ◽  
Male Meiosis ◽  
The Other ◽  
Chromosome 3 ◽  
Female Meiosis ◽  
Recombination Suppression ◽  
Strong Suppression ◽  
Heterozygous Condition ◽  
Male And Female

AbstractDuring meiosis, recombination ensures the allele exchange through crossovers (COs) between the homologous chromosomes and, additionally, their proper segregation. CO events are under a strict control but molecular mechanisms underlying CO regulation are still elusive. Some advances in this field were made by structural chromosomal rearrangements that are known at heterozygous state to impair COs in various organisms. In this paper, we have investigated the effect that a large pericentric inversion involving chromosome 3 of Arabidopsis thaliana has on male and female recombination. The inversion associated to a T-DNA dependent mutation likely resulted from a side effect of the T-DNA integration. Reciprocal backcross populations, each consisting of over 400 individuals, obtained from the T-DNA mutant and the wild type, both crossed with Landsberg, have been analyzed at genome-wide level by 143 SNPs. We found a strong suppression of COs in the rearranged region in both male and female meiosis. As expected, we did not detect single COs in the inverted region consistently with the post-meiotic selection operating against unbalanced gametes. Cytological analysis of chiasmata in F1 plants confirmed that COs are effectively dropping in chromosome 3 pair. Indeed, CO failure within the inversion is not altogether counterbalanced by CO increase in the regions outside the inversion on chromosome 3. Strikingly, this CO suppression induces a significant increase of COs in chromosome pairs 1, 2 and 5 in male meiosis. We conclude that these chromosomes acquire additional COs thereby compensating the recombination suppression occurring in chromosome 3, similarly to what has been described as interchromosomal (IC) effect in other organisms. In female meiosis, IC effect is not evident. This may be related to the fact that CO number in female is close to the minimum value imposed by the obligatory CO rule.Author SummaryIt is well known that chromosome structure changes in heterozygous condition influence the pattern of meiotic recombination at broad scale. In natural populations, inversions are recognized as the most effective force to reduce COs. In this way, adaptive allele combinations which otherwise would be broken by recombination are maintained. In the present work, we studied the effect on recombination of a large pericentric inversion involving Arabidopsis chromosome 3. The analysis on heterozygous populations provided evidence of strong recombination suppression in chromosome 3. However, the most striking aspect of this study is the finding that the failure of chromosome 3 to recombine is coupled to increased CO frequencies on the other chromosome pairs in male meiosis. These CO compensatory increases are strictly an interchromosomal (IC) effect as was first described in Drosophila. As far as we know, it is the first time IC effect has been reported in plants. Unfortunately, the molecular mechanisms underlying IC effect in the other organisms are still elusive. To understand how a CO change on just one chromosome triggers the global response of the meiocyte to obtain the adequate CO number/cell remains a fascinating question in sexually reproducing species.

scholarly journals Can pericentric inversion and C-heterochromatin cause interchromosomal effect leading to an increased aneuploidy in sperm nuclei?

2000 ◽  
Vol 2 (1) ◽  
pp. 91-91
Author(s):  
R Diukman ◽  
F Sardos Albertini ◽  
M Feigin ◽  
A Shacham ◽  
A Amiel
Keyword(s):  
Pericentric Inversion ◽  
Interchromosomal Effect ◽  
Sperm Nuclei

A case associated with Walker Warburg syndrome phenotype and homozygous pericentric inversion 9: coincidental finding or aetiological factor?

1999 ◽  
Vol 88 (5) ◽  
pp. 579-583 ◽  
Author(s):  
V. Baltaci ◽  
R. Örs ◽  
M. Kaya ◽  
S. Balci
Keyword(s):  
Pericentric Inversion ◽  
Aetiological Factor

scholarly journals Differential Gene Expression between Fungal Mating Types Is Associated with Sequence Degeneration

2020 ◽  
Vol 12 (4) ◽  
pp. 243-258 ◽  
Author(s):  
Wen-Juan Ma ◽  
Fantin Carpentier ◽  
Tatiana Giraud ◽  
Michael E Hood
Keyword(s):  
Differential Expression ◽  
Differentially Expressed Genes ◽  
Mating Type ◽  
Sex Chromosomes ◽  
Sex Chromosome ◽  
Gc Content ◽  
Differentially Expressed ◽  
Mating Types ◽  
Sexual Antagonism ◽  
Recombination Suppression

Abstract Degenerative mutations in non-recombining regions, such as in sex chromosomes, may lead to differential expression between alleles if mutations occur stochastically in one or the other allele. Reduced allelic expression due to degeneration has indeed been suggested to occur in various sex-chromosome systems. However, whether an association occurs between specific signatures of degeneration and differential expression between alleles has not been extensively tested, and sexual antagonism can also cause differential expression on sex chromosomes. The anther-smut fungus Microbotryum lychnidis-dioicae is ideal for testing associations between specific degenerative signatures and differential expression because 1) there are multiple evolutionary strata on the mating-type chromosomes, reflecting successive recombination suppression linked to mating-type loci; 2) separate haploid cultures of opposite mating types help identify differential expression between alleles; and 3) there is no sexual antagonism as a confounding factor accounting for differential expression. We found that differentially expressed genes were enriched in the four oldest evolutionary strata compared with other genomic compartments, and that, within compartments, several signatures of sequence degeneration were greater for differentially expressed than non-differentially expressed genes. Two particular degenerative signatures were significantly associated with lower expression levels within differentially expressed allele pairs: upstream insertion of transposable elements and mutations truncating the protein length. Other degenerative mutations associated with differential expression included nonsynonymous substitutions and altered intron or GC content. The association between differential expression and allele degeneration is relevant for a broad range of taxa where mating compatibility or sex is determined by genes located in large regions where recombination is suppressed.

Simultaneous Transport Promotion and Recombination Suppression in Perovskite Solar Cells by Defect Passivation with Li-Doped Graphitic Carbon Nitride

2021 ◽  
Vol 125 (10) ◽  
pp. 5525-5533
Author(s):  
Xiaomin Liang ◽  
Yanru Guo ◽  
Shuai Yuan ◽  
Dongping Zhu ◽  
Yi Wang ◽  
...  
Keyword(s):  
Solar Cells ◽  
Carbon Nitride ◽  
Perovskite Solar Cells ◽  
Graphitic Carbon ◽  
Graphitic Carbon Nitride ◽  
Recombination Suppression ◽  
Defect Passivation

scholarly journals Fertility problems in males carrying an inversion of chromosome 10

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 316-321
Author(s):  
Xinyue Zhang ◽  
Qingyang Shi ◽  
Yanhong Liu ◽  
Yuting Jiang ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Pericentric Inversion ◽  
Paracentric Inversion ◽  
Chromosome 10 ◽  
Partial Duplication ◽  
Recurrent Miscarriages ◽  
First Case ◽  
Fertility Problems ◽  
Male Carriers ◽  
Male Carrier

Abstract Chromosomal inversion is closely related to male infertility. Inversion carriers may produce abnormal gametes, which may lead to partial duplication/deletion of the embryonic chromosome and result in spontaneous abortion, a fetus with multiple anomalies, or birth of a malformed child. Genetic counselling remains challenging for these carriers in clinical practice. We report two male carriers with inversion of chromosome 10 and review 26 reported cases. In the first case, 46,XX,inv(10)(p13q22) of the fetal chromosome was found in prenatal diagnosis; this was inherited from the paternal side with 46XY,inv(10)(p13q22). Another case was a male carrier with inv(10)(q21.2q22.1). There have been 25 (89.3%) cases of pericentric inversion and three (10.7%) cases of paracentric inversion involving chromosome 10. Of 28 cases, nine were associated with pregestational infertility of the couples, while the other 19 cases were associated with gestational infertility of the couples or normozoospermia. The breakpoints at 10p15, 10p11, 10q11, and 10q21 were associated with pregestational infertility of the couples. The breakpoints at 10p15, 10p14, 10p13, 10p12, 10p11, 10q11, 10q21, 10q22, 10q23, 10q24, 10q25, and 10q26 were related to gestational infertility of the couples or normozoospermia. Although there is a high risk of infertility or recurrent miscarriages, carriers with inversion of chromosome 10 might produce healthy offspring. Natural pregnancy can be used as a choice for inversion carriers with recurrent spontaneous abortion.

Prenatal Diagnosis in Pericentric Inversion 6

2010 ◽  
Vol 10 (1-3) ◽  
pp. 175-178 ◽  
Author(s):  
J. Gazala ◽  
I. V. Amithkumar ◽  
J. Sabina ◽  
K.K. Praveena ◽  
J. Sujatha
Keyword(s):  
Prenatal Diagnosis ◽  
Pericentric Inversion

scholarly journals Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Lingzhan Xue ◽  
Yu Gao ◽  
Meiying Wu ◽  
Tian Tian ◽  
Haiping Fan ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Sex Chromosomes ◽  
Chromosome Pair ◽  
Sex Chromosome ◽  
Structural Variations ◽  
Recombination Suppression ◽  
Chromosome Differentiation ◽  
Y Chromosomes ◽  
Recent Origin ◽  
Mastacembelus Armatus

Abstract Background The origin of sex chromosomes requires the establishment of recombination suppression between the proto-sex chromosomes. In many fish species, the sex chromosome pair is homomorphic with a recent origin, providing species for studying how and why recombination suppression evolved in the initial stages of sex chromosome differentiation, but this requires accurate sequence assembly of the X and Y (or Z and W) chromosomes, which may be difficult if they are recently diverged. Results Here we produce a haplotype-resolved genome assembly of zig-zag eel (Mastacembelus armatus), an aquaculture fish, at the chromosomal scale. The diploid assembly is nearly gap-free, and in most chromosomes, we resolve the centromeric and subtelomeric heterochromatic sequences. In particular, the Y chromosome, including its highly repetitive short arm, has zero gaps. Using resequencing data, we identify a ~7 Mb fully sex-linked region (SLR), spanning the sex chromosome centromere and almost entirely embedded in the pericentromeric heterochromatin. The SLRs on the X and Y chromosomes are almost identical in sequence and gene content, but both are repetitive and heterochromatic, consistent with zero or low recombination. We further identify an HMG-domain containing gene HMGN6 in the SLR as a candidate sex-determining gene that is expressed at the onset of testis development. Conclusions Our study supports the idea that preexisting regions of low recombination, such as pericentromeric regions, can give rise to SLR in the absence of structural variations between the proto-sex chromosomes.

PERICENTRIC INVERSION OF CHROMOSOME 21 A POSSIBLE FURTHER CYTOGENETIC MECHANISM IN MONGOLISM

The Lancet ◽  
1962 ◽  
Vol 279 (7219) ◽  
pp. 21-23 ◽  
Author(s):  
J.E. Gray ◽  
D.E. Mutton ◽  
D.W. Ashby
Keyword(s):  
Pericentric Inversion ◽  
Chromosome 21
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