Implication of the nuclear trafficking of rabies virus P3 protein in viral pathogenicity

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A. A. Gusev ◽  
I. A. Puntus ◽  
A. S. Smailova

The results of alternative studies on the immunogenic activity of live rabies vaccines for oral immunization of wild carnivorous animals are presented. The method of evaluation of immunogenicity using a model of oral immunization in mice with experimental infection control rabies virus CVS in the dose of 10–100 MLD50/0,03 ml. Once entered immunizing dose for white mice, weighing 12–14 g were 56.200 MLD50, the titers of VNA ranged from 1:6 to 1:16 (3,0–4,0 log2) and above.


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