Assessment of simple indices based on a single fasting blood sample as a tool to estimate beta-cell function after total pancreatectomy with islet autotransplantation - a prospective study

2018 ◽  
Vol 32 (3) ◽  
pp. 280-290 ◽  
Author(s):  
Justyna E. Gołębiewska ◽  
Piotr J. Bachul ◽  
Natalie Fillman ◽  
Lindsay Basto ◽  
Mark R. Kijek ◽  
...  
Keyword(s):  
Beta Cell ◽  
Prospective Study ◽  
Blood Sample ◽  
Beta Cell Function ◽  
Cell Function ◽  
Total Pancreatectomy ◽  
Islet Autotransplantation ◽  
A Prospective Study

66 BETA CELL FUNCTION FOLLOWING ISLET AUTOTRANSPLANTATION

2005 ◽  
Vol 53 (2) ◽  
pp. S367.6-S367
Author(s):  
M. Salehi ◽  
H. R. Rilo ◽  
S. A. Ahmad ◽  
J. B. Matthews ◽  
A. M. Lowy ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Islet Autotransplantation

Preservation of Beta Cell Function Following Pancreatic Islet Autotransplantation.

2014 ◽  
Vol 98 ◽  
pp. 685-686
Author(s):  
O. Savari ◽  
K. Golab ◽  
L. Schenck ◽  
R. Grose ◽  
M. Tibudan ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Islet ◽  
Beta Cell Function ◽  
Cell Function ◽  
Islet Autotransplantation

Preservation of Beta Cell Function after Pancreatic Islet Autotransplantation: University of Chicago Experience

2015 ◽  
Vol 81 (4) ◽  
pp. 421-427 ◽  
Author(s):  
Omid Savari ◽  
Karolina Golab ◽  
Ling-Jia Wang ◽  
Lindsay Schenck ◽  
Randall Grose ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Portal Vein ◽  
Beta Cell ◽  
Glucose Control ◽  
Beta Cell Function ◽  
Cell Function ◽  
Insulin Independence ◽  
Islet Mass ◽  
Vein Thrombosis ◽  
Islet Autotransplantation

The aim of the study was to assess the rate of insulin independence in patients after total pancreatectomy (TP) and islet autotransplantation in our center. TP followed by islet auto-transplantation was performed in 10 patients. Severe unrelenting pain associated with chronic pancreatitis was the major indication for surgery. Islets were isolated using the modified Ricordi method and infused through the portal vein. Exogenous insulin therapy was implemented for at least two months posttransplant to support islet engraftment and was subsequently weaned off, if possible. Median follow-up was 26 months (range, 2 to 60 months). Median islet yield was 158,860 islet equivalents (IEQ) (range, 40,203 to 330,472 IEQ) with an average islet yield of 2,478 IEQ/g (range, 685 to 6,002 IEQ/g) of processed pancreas. One patient developed transient partial portal vein thrombosis, which resolved without sequela. Five (50%) patients are currently off insulin with excellent glucose control and HbA1c below 6. Patients who achieved and maintained insulin independence were transplanted with significantly more islets (median, 202,291 IEQ; range, 145,000 to 330,474 IEQ) than patients who required insulin support (64,348 IEQ; range, 40,203 to 260,476 IEQ; P < 0.05). Patient body mass index and time of chronic pancreatitis prior transplant procedure did not correlate with the outcome. The remaining five patients, who require insulin support, had present C-peptide in blood and experience good glucose control without incidence of severe hypoglycemic episodes. Islet autotransplantation efficiently preserved beta cell function in selected patients with chronic pancreatitis and the outcome correlated with transplanted islet mass.

Decline Pattern of Beta-cell Function in Adult-onset Latent Autoimmune Diabetes: an 8-year Prospective Study

2020 ◽  
Vol 105 (7) ◽  
pp. 2331-2340 ◽  
Author(s):  
Xia Li ◽  
Yan Chen ◽  
Yuting Xie ◽  
Yufei Xiang ◽  
Xiang Yan ◽  
...  
Keyword(s):  
Beta Cell ◽  
Prospective Study ◽  
Beta Cell Function ◽  
Cell Function ◽  
Autoimmune Diabetes ◽  
Dropout Rate ◽  
Acid Decarboxylase ◽  
Stable Mode ◽  
C Peptide

Abstract Objective To explore the decline pattern and possible determinants of beta-cell function progression in patients with latent-onset autoimmune diabetes in adults (LADA). Research Design and Methods In this 8-year prospective study, 106 LADA individuals underwent annual follow-up and their pattern of beta-cell function progression was assessed. Beta-cell function failure was defined by fasting C-peptide (FCP) &lt; 75 pmol/L. Other clinical characteristics, including age of onset, body mass index (BMI), and glutamic acid decarboxylase autoantibody (GADA) titer, were analyzed to find out possible determinants of beta-cell function progression. Results The dropout rate was 4.7%. During the 8-year follow-up period, 29 (28.7%) of the 101 subjects developed beta-cell function failure. The decline pattern of C-peptide in LADA was biphasic, showing an initial rapid linear progression and then followed by a stable mode. The declination speed of FCP was 55.19 pmol/L/year (95% CI, −62.54 to −47.84, P &lt; 0.001) during the first 5 years and 4.62 pmol/L/year (95% CI, −69.83 to 60.60, P = 0.790) thereafter. Further analysis showed that GADA titer was the most valuable discriminatory parameter related to a higher risk of development of beta-cell function failure (GADA titer of 173.5 WHO units/mL; area under the curve [AUC], 0.824). Beta-cell function failure occurred in 71.3% of high-GADA titer patients while only 6.2% of low-titer patients. Conclusions The decline pattern of C-peptide was a fast-followed-by-slow biphasic mode, with about a quarter of LADA patients developing beta-cell function failure during the first 8 years. GADA titer less than 173.5 WHO units /mL was propitious for the preservation of beta-cell function.

scholarly journals Comparative evaluation of simple indices using a single fasting blood sample to estimate beta cell function after islet transplantation

2018 ◽  
Vol 18 (4) ◽  
pp. 990-997 ◽  
Author(s):  
Justyna E. Gołębiewska ◽  
Julia Solomina ◽  
Celeste Thomas ◽  
Mark R. Kijek ◽  
Piotr J. Bachul ◽  
...  
Keyword(s):  
Beta Cell ◽  
Blood Sample ◽  
Islet Transplantation ◽  
Beta Cell Function ◽  
Comparative Evaluation ◽  
Cell Function
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