Impacts of single nucleotide polymorphisms in Fc gamma receptor IIA ( rs1801274 ) on lung transplant outcomes among Japanese lung transplant recipients

2021 ◽  
Author(s):  
Hidenao Kayawake ◽  
Toyofumi F. Chen‐Yoshikawa ◽  
Satona Tanaka ◽  
Yuka Tanaka ◽  
Hideki Ohdan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Lung Transplant ◽  
Nucleotide Polymorphisms ◽  
Transplant Recipients ◽  
Single Nucleotide ◽  
Fc Gamma Receptor ◽  
Transplant Outcomes ◽  
Gamma Receptor ◽  
Lung Transplant Recipients

scholarly journals Effect of Positive Perioperative Donor and Recipient Respiratory Bacterial Cultures on Early Post-transplant Outcomes in Lung Transplant Recipients

2016 ◽  
Vol 3 (suppl_1) ◽  
Author(s):  
Crystal Howell ◽  
Christopher Paciullo ◽  
G. Marshall Lyon ◽  
David Neujahr ◽  
Michael Hurtik
Keyword(s):  
Lung Transplant ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Transplant Outcomes ◽  
Bacterial Cultures ◽  
Lung Transplant Recipients

scholarly journals Effects of single-nucleotide polymorphisms in MTHFR and MTRR on mortality and allograft loss in kidney transplant recipients

2005 ◽  
Vol 68 (6) ◽  
pp. 2857-2862 ◽  
Author(s):  
Wolfgang C. Winkelmayer ◽  
Reinhard Kramar ◽  
Gere Sunder-Plassmann ◽  
Manuela Fadinger
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Kidney Transplant ◽  
Nucleotide Polymorphisms ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Single Nucleotide ◽  
Allograft Loss

The role of single nucleotide polymorphisms of CYP3A and ABCB1 on tacrolimus predose concentration in kidney transplant recipients

2017 ◽  
Vol 88 (S1) ◽  
pp. 115-118 ◽  
Author(s):  
Gregor Mlinšek ◽  
Vita Dolžan ◽  
Katja Goričar ◽  
Jadranka Buturović-Ponikvar ◽  
Miha Arnol
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Kidney Transplant ◽  
Nucleotide Polymorphisms ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Single Nucleotide

Effect of positive perioperative donor and recipient respiratory bacterial cultures on early post-transplant outcomes in lung transplant recipients

2017 ◽  
Vol 19 (6) ◽  
pp. e12760 ◽  
Author(s):  
Crystal K. Howell ◽  
Christopher A. Paciullo ◽  
G. Marshall Lyon ◽  
David Neujahr ◽  
Peter Lyu ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Transplant Recipients ◽  
Post Transplant ◽  
Transplant Outcomes ◽  
Bacterial Cultures ◽  
Lung Transplant Recipients

scholarly journals Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality

2019 ◽  
Vol 54 (2) ◽  
pp. 1802126 ◽  
Author(s):  
Julieta Lazarte ◽  
Jin Ma ◽  
Tereza Martinu ◽  
Liran Levy ◽  
William Klement ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Lung Transplantation ◽  
Human Leukocyte Antigen ◽  
Mortality Risk ◽  
Lung Transplant ◽  
Multivariable Analysis ◽  
Human Leukocyte ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Leukocyte Antigen

Human leukocyte antigen (HLA)-G is a non-classical HLA that inhibits immune responses. Its expression is modified by single nucleotide polymorphisms (SNPs), which are associated with transplant outcomes. Our aim was to investigate the association of donor and recipient HLA-G SNPs with chronic lung allograft dysfunction (CLAD) and mortality after lung transplantation.In this single-centre study, we examined 11 HLA-G SNPs in 345 consecutive recipients and 297 donors of a first bilateral lung transplant. A multivariable Cox proportional hazards model assessed associations of SNPs with death and CLAD. Transbronchial biopsies (TBBx) and bronchoalveolar lavage (BAL) samples were examined using quantitative PCR, ELISA and immunofluorescence.Over a median of 4.75 years, 142 patients (41%) developed CLAD; 170 (49%) died. Multivariable analysis revealed donor SNP +3142 (GG+CG versus CC) was associated with increased mortality (hazard ratio 1.78, 95% CI 1.12–2.84; p=0.015). In contrast, five donor SNPs, -201(CC), -716(TT), -56(CC), G*01:03(AA) and 14 bp INDEL, conferred reduced mortality risk. Specific donor–recipient SNP pairings reduced CLAD risk. Predominantly epithelial HLA-G expression was observed on TBBx without rejection. Soluble HLA-G was present in higher concentrations in the BAL samples of patients who later developed CLAD.Specific donor SNPs were associated with mortality risk after lung transplantation, while certain donor–recipient SNP pairings modulated CLAD risk. TBBx demonstrated predominantly epithelial, and therefore presumably donor-derived, HLA-G expression in keeping with these observations. This study is the first to demonstrate an effect of donor HLA-G SNPs on lung transplantation outcome.

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