Identification of ventilator‐associated pneumonia in dogs and evaluation of empiric antimicrobial therapy: 13 cases (2012–2016)

2020 ◽  
Author(s):  
Christine Fox ◽  
Meredith Daly ◽  
Tara Bellis
Keyword(s):  
Antimicrobial Therapy ◽  
Ventilator Associated Pneumonia ◽  
Empiric Antimicrobial Therapy

scholarly journals Colistin as a first choice antibiotic for the initial empiric antimicrobial therapy of ventilator-associated pneumonia

2007 ◽  
Vol 30 (6) ◽  
pp. 1234-1235 ◽  
Author(s):  
K. Ioannides ◽  
P. Myrianthefs ◽  
G. Baltopoulos
Keyword(s):  
Antimicrobial Therapy ◽  
Ventilator Associated Pneumonia ◽  
Empiric Antimicrobial Therapy ◽  
First Choice

scholarly journals Empiric antimicrobial therapy for ventilator-associated pneumonia after brain injury

2016 ◽  
Vol 47 (4) ◽  
pp. 1219-1228 ◽  
Author(s):  
Antoine Roquilly ◽  
Fanny Feuillet ◽  
Philippe Seguin ◽  
Sigismond Lasocki ◽  
Raphael Cinotti ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Antimicrobial Therapy ◽  
Predictive Value ◽  
Validation Cohort ◽  
Characteristic Curve ◽  
Ventilator Associated Pneumonia ◽  
Burn Patients ◽  
Empiric Antimicrobial Therapy ◽  
Brain Injured ◽  
Injured Patients

Issues regarding recommendations on empiric antimicrobial therapy for ventilator-associated pneumonia (VAP) have emerged in specific populations.To develop and validate a score to guide empiric therapy in brain-injured patients with VAP, we prospectively followed a cohort of 379 brain-injured patients in five intensive care units. The score was externally validated in an independent cohort of 252 brain-injured patients and its extrapolation was tested in 221 burn patients.The multivariate analysis for predicting resistance (incidence 16.4%) showed two independent factors: preceding antimicrobial therapy ≥48 h (p<0.001) and VAP onset ≥10 days (p<0.001); the area under the receiver operating characteristic curve (AUC) was 0.822 (95% CI 0.770–0.883) in the learning cohort and 0.805 (95% CI 0.732–0.877) in the validation cohort. The score built from the factors selected in multivariate analysis predicted resistance with a sensitivity of 83%, a specificity of 71%, a positive predictive value of 37% and a negative predictive value of 96% in the validation cohort. The AUC of the multivariate analysis was poor in burn patients (0.671, 95% CI 0.596–0.751).Limited-spectrum empirical antimicrobial therapy has low risk of failure in brain-injured patients presenting with VAP before day 10 and when prior antimicrobial therapy lasts <48 h.

Empiric antimicrobial therapy for early-onset pneumonia in severe trauma patients

2022 ◽  
Author(s):  
Maël Gennequin ◽  
Delphine Bachelet ◽  
Philippine Eloy ◽  
Jean-Denis Moyer ◽  
Antoine Roquilly ◽  
...  
Keyword(s):  
Antimicrobial Therapy ◽  
Early Onset ◽  
Severe Trauma ◽  
Trauma Patients ◽  
Empiric Antimicrobial Therapy

scholarly journals Appropriateness of empiric antimicrobial therapy with imipenem/colistin in severe septic patients: observational cohort study

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Ahlem Trifi ◽  
Sami Abdellatif ◽  
Cyrine Abdennebi ◽  
Foued Daly ◽  
Rochdi Nasri ◽  
...  
Keyword(s):  
Cohort Study ◽  
Antimicrobial Therapy ◽  
Observational Cohort Study ◽  
Empiric Antimicrobial Therapy ◽  
Observational Cohort

scholarly journals Impact of Inactive Empiric Antimicrobial Therapy on Inpatient Mortality and Length of Stay

2006 ◽  
Vol 50 (10) ◽  
pp. 3355-3360 ◽  
Author(s):  
Kimberly K. Scarsi ◽  
Joe M. Feinglass ◽  
Marc H. Scheetz ◽  
Michael J. Postelnick ◽  
Maureen K. Bolon ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Antimicrobial Therapy ◽  
Medical Center ◽  
Academic Medical Center ◽  
Bloodstream Infections ◽  
Empiric Therapy ◽  
Inpatient Mortality ◽  
In Vitro Susceptibility ◽  
Empiric Antimicrobial Therapy

ABSTRACT The consequences of inactive empiric antimicrobial therapy are not well-described and may cause prolonged hospitalization or infection-related mortality. In vitro susceptibility results for 884 patients hospitalized at an academic medical center with gram-negative bloodstream infections (GNBI) from 2001 to 2003 were matched to antimicrobial orders within 24 h of culture. Clinical characteristics, organism, inpatient mortality, and length of stay after culture for patients with GNBI were compared between patients receiving active versus inactive empiric antimicrobial therapy. A total of 14.1% of patients with GNBI received inactive empiric therapy, defined as no antimicrobial therapy within 24 h of the culture active against the identified organism based on in vitro microbiology reports. Patients who received inactive therapy were more likely to be younger, to be infected with Pseudomonas aeruginosa, to have a nosocomial infection, and to receive antimicrobial monotherapy but less likely to be bacteremic with Escherichia coli or to have sepsis (P < 0.05). There were no significant differences in mortality between patients receiving active versus inactive empiric therapy (16.1% versus 13.6%, respectively) or in length of stay after positive culture (11.5 days versus 12.6 days, respectively). Only 45 patients had greater than 2 days of exposure to inactive therapy; however, 8/30 patients (26.7%) who never received active antimicrobial therapy died while in the hospital. Inactive empiric therapy was more common in healthier patients. Inactive antimicrobial therapy in the first 24 h did not significantly impact average outcomes for GNBI among hospitalized patients but may have caused harm to specific individuals.

Non-nephrotoxic empiric antimicrobial therapy in febrile neutropenic cancer patients

1992 ◽  
Vol 28 (4-5) ◽  
pp. 867-870 ◽  
Author(s):  
Joseph Kattan ◽  
Jean-Pierre Droz ◽  
Vincent Ribrag ◽  
Mohamed Azab ◽  
Arnaud Boutan-Laroze ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Antimicrobial Therapy ◽  
Empiric Antimicrobial Therapy

Causative Pathogen Dictates Optimal Duration of Antimicrobial Therapy for Ventilator-Associated Pneumonia in Trauma Patients

2011 ◽  
Vol 212 (4) ◽  
pp. 476-484 ◽  
Author(s):  
Louis J. Magnotti ◽  
Martin A. Croce ◽  
Ben L. Zarzaur ◽  
Joseph M. Swanson ◽  
G. Christopher Wood ◽  
...  
Keyword(s):  
Antimicrobial Therapy ◽  
Trauma Patients ◽  
Ventilator Associated Pneumonia ◽  
Causative Pathogen ◽  
Optimal Duration

683: NARROW-SPECTRUM EMPIRIC ANTIMICROBIAL THERAPY FOR VAP IN CRITICALLY ILL TRAUMA PATIENTS

2018 ◽  
Vol 46 (1) ◽  
pp. 328-328
Author(s):  
Holly Krohn ◽  
Jennifer Roth ◽  
Peter Colley ◽  
Geoffrey Funk ◽  
Michael Foreman
Keyword(s):  
Critically Ill ◽  
Antimicrobial Therapy ◽  
Trauma Patients ◽  
Narrow Spectrum ◽  
Empiric Antimicrobial Therapy
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