scholarly journals Gene expression analyses reveal metabolic specifications in acute O2-sensing chemoreceptor cells

2017 ◽  
Vol 595 (18) ◽  
pp. 6091-6120 ◽  
Author(s):  
Lin Gao ◽  
Victoria Bonilla-Henao ◽  
Paula García-Flores ◽  
Ignacio Arias-Mayenco ◽  
Patricia Ortega-Sáenz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Analyses ◽  
Chemoreceptor Cells ◽  
O2 Sensing

Exon-level gene expression analyses of primary neuroblastoma improves risk prediction and identifies JARID1C as a candidate target

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
A Schramm ◽  
B Schowe ◽  
T Thor ◽  
M Baumann ◽  
S Dreesmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Risk Prediction ◽  
Gene Expression Analyses ◽  
Candidate Target ◽  
Exon Level

Different types of disease‐causing non‐coding variants revealed by genomic and gene expression analyses in families with X‐linked intellectual disability

2021 ◽  
Author(s):  
Michael J. Field ◽  
Raman Kumar ◽  
Anna Hackett ◽  
Sayaka Kayumi ◽  
Cheryl A. Shoubridge ◽  
...  
Keyword(s):  
Gene Expression ◽  
Intellectual Disability ◽  
Gene Expression Analyses ◽  
Different Types ◽  
Coding Variants

scholarly journals Correction to: Gene expression analyses on multi‑target mode of action of black cohosh in menopausal complaints – a pilot study in rodents

2021 ◽  
Author(s):  
Petra Stute ◽  
Stefan Ehrentraut ◽  
Hans-Heinrich Henneicke-von Zepelin ◽  
Petra Nicken
Keyword(s):  
Gene Expression ◽  
Pilot Study ◽  
Mode Of Action ◽  
Black Cohosh ◽  
Target Mode ◽  
Gene Expression Analyses

scholarly journals Unearthing LTR retrotransposon gag genes co-opted in the deep evolution of eukaryotes

2021 ◽  
Author(s):  
Jianhua Wang ◽  
Guan-Zhu Han
Keyword(s):  
Gene Expression ◽  
Selective Pressure ◽  
Ltr Retrotransposon ◽  
Ltr Retrotransposons ◽  
Cellular Functions ◽  
The Family ◽  
Family Level ◽  
Gene Expression Analyses ◽  
Comprehensive Picture ◽  
Gypsy Retrotransposons

Abstract LTR retrotransposons comprise a major component of the genomes of eukaryotes. On occasion, retrotransposon genes can be recruited by their hosts for diverse functions, a process formally referred to as co-option. However, a comprehensive picture of LTR retrotransposon gag gene co-option in eukaryotes is still lacking, with several documented cases exclusively involving Ty3/Gypsy retrotransposons in animals. Here we use a phylogenomic approach to systemically unearth co-option of retrotransposon gag genes above the family level of taxonomy in 2,011 eukaryotes, namely co-option occurring during the deep evolution of eukaryotes. We identify a total of 14 independent gag gene co-option events across more than 740 eukaryote families, eight of which have not been reported previously. Among these retrotransposon gag gene co-option events, nine, four, and one involve gag genes of Ty3/Gypsy, Ty1/Copia, and Bel-Pao retrotransposons, respectively. Seven, four, and three co-option events occurred in animals, plants, and fungi, respectively. Interestingly, two co-option events took place in the early evolution of angiosperms. Both selective pressure and gene expression analyses further support that these co-opted gag genes might perform diverse cellular functions in their hosts, and several co-opted gag genes might be subject to positive selection. Taken together, our results provide a comprehensive picture of LTR retrotransposon gag gene co-option events that occurred during the deep evolution of eukaryotes, and suggest paucity of LTR retrotransposon gag gene co-option during the deep evolution of eukaryotes.

ADAP is a possible negative regulator of glucosinolate biosynthesis in Arabidopsis thaliana based on clustering and gene expression analyses

2021 ◽  
Vol 134 (2) ◽  
pp. 327-339
Author(s):  
S. Harun ◽  
E. R. Rohani ◽  
M. Ohme-Takagi ◽  
H.-H. Goh ◽  
Z.-A. Mohamed-Hussein
Keyword(s):  
Gene Expression ◽  
Arabidopsis Thaliana ◽  
Negative Regulator ◽  
Glucosinolate Biosynthesis ◽  
Gene Expression Analyses

scholarly journals Acute Oxygen Sensing in Heme Oxygenase-2 Null Mice

2006 ◽  
Vol 128 (4) ◽  
pp. 405-411 ◽  
Author(s):  
Patricia Ortega-Sáenz ◽  
Alberto Pascual ◽  
Raquel Gómez-Díaz ◽  
José López-Barneo
Keyword(s):  
Gene Expression ◽  
K Channel ◽  
Α Subunit ◽  
Organ Growth ◽  
K Channels ◽  
Channel Gene ◽  
Sensitive Organ ◽  
Stress Dependent ◽  
Acute Oxygen Sensing ◽  
O2 Sensing

Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to be the acute O2 sensor in the carotid body (CB). We have tested the physiological contribution of this enzyme to O2 sensing using HO-2 null mice. HO-2 deficiency leads to a CB phenotype characterized by organ growth and alteration in the expression of stress-dependent genes, including the maxi-K+ channel α-subunit. However, sensitivity to hypoxia of CB is remarkably similar in HO-2 null animals and their control littermates. Moreover, the response to hypoxia in mouse and rat CB cells was maintained after blockade of maxi-K+ channels with iberiotoxin. Hypoxia responsiveness of the adrenal medulla (AM) (another acutely responding O2-sensitive organ) was also unaltered by HO-2 deficiency. Our data suggest that redox disregulation resulting from HO-2 deficiency affects maxi-K+ channel gene expression but it does not alter the intrinsic O2 sensitivity of CB or AM cells. Therefore, HO-2 is not a universally used acute O2 sensor.

RETRACTED ARTICLE: Gene expression analyses to explore the biomarkers and therapeutic targets for gliomas

2014 ◽  
Vol 36 (3) ◽  
pp. 403-409 ◽  
Author(s):  
Lina Wang ◽  
Bo Wei ◽  
Guozhang Hu ◽  
Le Wang ◽  
Ying Jin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Therapeutic Targets ◽  
Gene Expression Analyses ◽  
Retracted Article

scholarly journals Identifying targets for COPD treatment through gene expression analyses

2008 ◽  
Vol Volume 3 ◽  
pp. 359-370 ◽  
Author(s):  
Augustine Choi ◽  
SW Ryter ◽  
Chen ◽  
Pyo Kim
Keyword(s):  
Gene Expression ◽  
Gene Expression Analyses
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