scholarly journals Ca 2+ ‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease

2021 ◽  
Author(s):  
Stuart G. Cull‐Candy ◽  
Mark Farrant
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptors ◽  
Auxiliary Subunits

scholarly journals Imbalanced post- and extrasynaptic SHANK2A functions during development affect social behavior in SHANK2-mediated neuropsychiatric disorders

2021 ◽  
Author(s):  
Ahmed Eltokhi ◽  
Miguel A. Gonzalez-Lozano ◽  
Lars-Lennart Oettl ◽  
Andrey Rozov ◽  
Claudia Pitzer ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Social Interaction ◽  
Social Behavior ◽  
Ampa Receptors ◽  
Signal To Noise Ratio ◽  
Signal Transmission ◽  
Neuropsychiatric Disorders ◽  
Autism Spectrum ◽  
Strong Impact ◽  
Odor Processing

AbstractMutations in SHANK genes play an undisputed role in neuropsychiatric disorders. Until now, research has focused on the postsynaptic function of SHANKs, and prominent postsynaptic alterations in glutamatergic signal transmission have been reported in Shank KO mouse models. Recent studies have also suggested a possible presynaptic function of SHANK proteins, but these remain poorly defined. In this study, we examined how SHANK2 can mediate electrophysiological, molecular, and behavioral effects by conditionally overexpressing either wild-type SHANK2A or the extrasynaptic SHANK2A(R462X) variant. SHANK2A overexpression affected pre- and postsynaptic targets and revealed a reversible, development-dependent autism spectrum disorder-like behavior. SHANK2A also mediated redistribution of Ca2+-permeable AMPA receptors between apical and basal hippocampal CA1 dendrites, leading to impaired synaptic plasticity in the basal dendrites. Moreover, SHANK2A overexpression reduced social interaction and increased the excitatory noise in the olfactory cortex during odor processing. In contrast, overexpression of the extrasynaptic SHANK2A(R462X) variant did not impair hippocampal synaptic plasticity, but still altered the expression of presynaptic/axonal signaling proteins. We also observed an attention-deficit/hyperactivity-like behavior and improved social interaction along with enhanced signal-to-noise ratio in cortical odor processing. Our results suggest that the disruption of pre- and postsynaptic SHANK2 functions caused by SHANK2 mutations has a strong impact on social behavior. These findings indicate that pre- and postsynaptic SHANK2 actions cooperate for normal neuronal function, and that an imbalance between these functions may lead to different neuropsychiatric disorders.

AMPA receptors and synaptic plasticity: a chemist's perspective

2010 ◽  
Vol 6 (2) ◽  
pp. 89-97 ◽  
Author(s):  
James J Fleming ◽  
Pamela M England
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptors

scholarly journals Single and Repeated Administration of Methylphenidate Modulates Synaptic Plasticity in Opposite Directions via Insertion of AMPA Receptors in Rat Hippocampal Neurons

2018 ◽  
Vol 9 ◽  
Author(s):  
Claudia Carvallo ◽  
Darwin Contreras ◽  
Gonzalo Ugarte ◽  
Ricardo Delgado ◽  
Floria Pancetti ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Repeated Administration ◽  
Single And Repeated Administration

Participation of Ca2+-Permeable AMPA Receptors in Synaptic Plasticity

2020 ◽  
Vol 14 (3) ◽  
pp. 194-204
Author(s):  
L. P. Dolgacheva ◽  
S. T. Tuleukhanov ◽  
V. P. Zinchenko
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptors

scholarly journals AMPA receptors in the synapse turnover by monomer diffusion

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jyoji Morise ◽  
Kenichi G. N. Suzuki ◽  
Ayaka Kitagawa ◽  
Yoshihiko Wakazono ◽  
Kogo Takamiya ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Plasma Membrane ◽  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Ampa Receptors ◽  
Single Molecules ◽  
Lateral Diffusion ◽  
Synaptic Function ◽  
Synaptic Activity ◽  
Monomer Diffusion

AbstractThe number and subunit compositions of AMPA receptors (AMPARs), hetero- or homotetramers composed of four subunits GluA1–4, in the synapse is carefully tuned to sustain basic synaptic activity. This enables stimulation-induced synaptic plasticity, which is central to learning and memory. The AMPAR tetramers have been widely believed to be stable from their formation in the endoplasmic reticulum until their proteolytic decomposition. However, by observing GluA1 and GluA2 at the level of single molecules, we find that the homo- and heterotetramers are metastable, instantaneously falling apart into monomers, dimers, or trimers (in 100 and 200 ms, respectively), which readily form tetramers again. In the dendritic plasma membrane, GluA1 and GluA2 monomers and dimers are far more mobile than tetramers and enter and exit from the synaptic regions. We conclude that AMPAR turnover by lateral diffusion, essential for sustaining synaptic function, is largely done by monomers of AMPAR subunits, rather than preformed tetramers.

scholarly journals Phosphorylation of AMPA Receptors Is Required for Sensory Deprivation-Induced Homeostatic Synaptic Plasticity

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18264 ◽  
Author(s):  
Anubhuti Goel ◽  
Linda W. Xu ◽  
Kevin P. Snyder ◽  
Lihua Song ◽  
Yamila Goenaga-Vazquez ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptors ◽  
Sensory Deprivation ◽  
Homeostatic Synaptic Plasticity

Ischemia-induced synaptic plasticity drives sustained expression of calcium-permeable AMPA receptors in the hippocampus

2013 ◽  
Vol 65 ◽  
pp. 114-122 ◽  
Author(s):  
Raquel B. Dias ◽  
Diogo M. Rombo ◽  
Joaquim A. Ribeiro ◽  
Ana M. Sebastião
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptors

scholarly journals The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity

2014 ◽  
Vol 8 ◽  
Author(s):  
Thomas E. Chater ◽  
Yukiko Goda
Keyword(s):  
Synaptic Plasticity ◽  
Ampa Receptors
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