The vascular response to acute hyperglycemia: what is the role of exercise capacity?

2021 ◽  
Author(s):  
Andrew R. Heckel ◽  
Burak T. Cilhoroz ◽  
Jared Rosenberg
Keyword(s):  
Exercise Capacity ◽  
Vascular Response ◽  
Acute Hyperglycemia

scholarly journals 0329 : Role of the estrogen receptor alpha (ERalpha) in the vascular response to shear stress in mice

2015 ◽  
Vol 7 (2) ◽  
pp. 142
Author(s):  
Julie Favre ◽  
Emilie Vessière ◽  
Anne-Laure Guihot ◽  
Linda Grimaud ◽  
Jean-François Arnal ◽  
...  
Keyword(s):  
Shear Stress ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Vascular Response ◽  
Receptor Alpha

Abstract 431: Mitochondrial Fission in the Heart is an Adaptation to Increased Energetic Demands: The Role of Physiologic Fragmentation

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Michael Coronado ◽  
Giovanni Fajardo ◽  
Kim Nguyen ◽  
Mingming Zhao ◽  
Kristina Bezold Kooiker ◽  
...  
Keyword(s):  
Cell Death ◽  
Exercise Capacity ◽  
Mitochondrial Function ◽  
Adrenergic Receptor ◽  
Mitochondrial Fission ◽  
Physiological Adaptation ◽  
Mitochondrial Fragmentation ◽  
Energetic Demand ◽  
Adaptation To Exercise

Mitochondria play a dual role in the heart, responsible for meeting energetic demands and regulating cell death. Current paradigms hold that mitochondrial fission and fragmentation are the result of pathologic stresses such as ischemia, are an indicator of poor mitochondrial health, and lead to mitophagy and cell death. However, recent studies demonstrate that inhibiting fission also results in cardiac impairment, suggesting that fission is important for maintaining normal mitochondrial function. In this study, we identify a novel role for mitochondrial fragmentation as a normal physiological adaptation to increased energetic demand. Using two models of exercise, we demonstrate that “physiologic” mitochondrial fragmentation occurs, results in enhanced mitochondrial function, and is mediated through beta 1-adrenergic receptor signaling. Similar to pathologic fragmentation, physiologic fragmentation is induced by activation of Drp1; however, unlike pathologic fragmentation, membrane potential is maintained and regulators of mitophagy are downregulated. To confirm the role of fragmentation as a physiological adaptation to exercise, we inhibited the pro-fission mediator Drp1 in mice using the peptide inhibitor P110 and had mice undergo exercise. Mice treated with P110 had significantly decreased exercise capacity, decreased fragmentation and inactive Drp1 vs controls. To further confirm these findings, we generated cardiac-specific Drp1 KO mice and had them undergo exercise. Mice with cardiac specific Drp1 KO had significantly decreased exercise capacity and abnormally large mitochondria compared to controls. These findings indicate the requirement for physiological mitochondrial fragmentation to meet the energetic demands of exercise and support the still evolving conceptual framework, where fragmentation plays a role in the balance between mitochondrial maintenance of normal physiology and response to disease.

scholarly journals The concentration of ascorbic acid in the cerebral cortex and internal organs of rats in chronic and acute hyperglycemia

1998 ◽  
Vol 44 (1) ◽  
pp. 40-42
Author(s):  
I. P. Grigoriev
Keyword(s):  
Ascorbic Acid ◽  
Brain Cortex ◽  
Mental Disease ◽  
Streptozotocin Diabetes ◽  
Causative Role ◽  
Internal Organs ◽  
Acute Hyperglycemia ◽  
Acute Hypoglycemia ◽  
The Brain

The author hypothesizes a probable causative role of alteration of ascorbic acid concentration in the brain in the development of mental disease in diabetics. In order to verify this hypothesis, ascorbic acid was measured in the brain cortex of rats 21 days after induction of streptozotocin diabetes or 1 h after intraperitoneal injection of glucose in a dose of 5 g/kg. Ascorbic acid level was increased both in diabetes (456+26 yg/g tissue versus 415+37 \vg/g in the control, p<0.01) and in acute hyperglycemia (475+54 \tg/g versus 406+65 \xg/g in the control, p<0.001). This confirmed that changed concentration of ascorbic acid in the brain can promote the development of a mental disease in diabetics. In the liver the concentration of ascorbic acid was decreased in streptozotocin diabetes (by 17%), p<0.001) and increased in acute hypoglycemia (by 24%, p<0.01). The findings permit us to hypothesize that hypoglycemia inhibits the production of ascorbic acid from the liver to the blood in rats and impedes the transport of ascorbic acid through the gut wall into the blood in humans.

scholarly journals Adenosine A 2A Receptor and Vascular Response: Role of Soluble Epoxide Hydrolase, Adenosine A 1 Receptor and Angiotensin‐II

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Stephanie Agba ◽  
Ahmed Hanif ◽  
Catherine Ledent ◽  
Stephen Tilley ◽  
Christophe Morisseau ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Vascular Response

scholarly journals Key Role of RV Hypertrophy for Maintaining Exercise Capacity in Adults with Repaired Tetralogy of Fallot

2012 ◽  
Vol 21 ◽  
pp. S295
Author(s):  
M. Seneviratne ◽  
S. O’Meagher ◽  
P. Munoz ◽  
D. Celermajer ◽  
R. Puranik
Keyword(s):  
Tetralogy Of Fallot ◽  
Exercise Capacity ◽  
Repaired Tetralogy Of Fallot

scholarly journals On the role of abnormal DLCOin ex-smokers without airflow limitation: symptoms, exercise capacity and hyperpolarised helium-3 MRI

Thorax ◽  
2013 ◽  
Vol 68 (8) ◽  
pp. 752-759 ◽  
Author(s):  
Miranda Kirby ◽  
Amir Owrangi ◽  
Sarah Svenningsen ◽  
Andrew Wheatley ◽  
Harvey O Coxson ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Airflow Limitation ◽  
Helium 3
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