Dynamic Contrast-Enhanced MRI and Fractal Characteristics of Percolation Clusters in Two-Dimensional Tumor Blood Perfusion

1999 ◽  
Vol 121 (5) ◽  
pp. 480-486 ◽  
Author(s):  
O. I. Craciunescu ◽  
S. K. Das ◽  
S. T. Clegg
Keyword(s):  
Tumor Tissue ◽  
Blood Perfusion ◽  
Percolation Cluster ◽  
Three Dimensions ◽  
Invasion Percolation ◽  
Two Dimensional ◽  
Tumor Perfusion ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Fractal Characteristics

Dynamic contrast-enhanced magnetic resonance imaging (DE-MRI) of the tumor blood pool is used to study tumor tissue perfusion. The results are then analyzed using percolation models. Percolation cluster geometry is depicted using the wash-in component of MRI contrast signal intensity. Fractal characteristics are determined for each two-dimensional cluster. The invasion percolation model is used to describe the evolution of the tumor perfusion front. Although tumor perfusion can be depicted rigorously only in three dimensions, two-dimensional cases are used to validate the methodology. It is concluded that the blood perfusion in a two-dimensional tumor vessel network has a fractal structure and that the evolution of the perfusion front can be characterized using invasion percolation. For all the cases studied, the front starts to grow from the periphery of the tumor (where the feeding vessel was assumed to lie) and continues to grow toward the center of the tumor, accounting for the well-documented perfused periphery and necrotic core of the tumor tissue.

scholarly journals Dynamic contrast-enhanced magnetic resonance imaging for monitoring neovascularization during bone regeneration—a randomized in vivo study in rabbits

2021 ◽  
Author(s):  
L. A. R. Righesso ◽  
M. Terekhov ◽  
H. Götz ◽  
M. Ackermann ◽  
T. Emrich ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Bone Regeneration ◽  
Blood Perfusion ◽  
Autogenous Bone ◽  
Resonance Imaging ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Abstract Objectives Micro-computed tomography (μ-CT) and histology, the current gold standard methods for assessing the formation of new bone and blood vessels, are invasive and/or destructive. With that in mind, a more conservative tool, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), was tested for its accuracy and reproducibility in monitoring neovascularization during bone regeneration. Additionally, the suitability of blood perfusion as a surrogate of the efficacy of osteoplastic materials was evaluated. Materials and methods Sixteen rabbits were used and equally divided into four groups, according to the time of euthanasia (2, 3, 4, and 6 weeks after surgery). The animals were submitted to two 8-mm craniotomies that were filled with blood or autogenous bone. Neovascularization was assessed in vivo through DCE-MRI, and bone regeneration, ex vivo, through μ-CT and histology. Results The defects could be consistently identified, and their blood perfusion measured through DCE-MRI, there being statistically significant differences within the blood clot group between 3 and 6 weeks (p = 0.029), and between the former and autogenous bone at six weeks (p = 0.017). Nonetheless, no significant correlations between DCE-MRI findings on neovascularization and μ-CT (r =−0.101, 95% CI [−0.445; 0.268]) or histology (r = 0.305, 95% CI [−0.133; 0.644]) findings on bone regeneration were observed. Conclusions These results support the hypothesis that DCE-MRI can be used to monitor neovascularization but contradict the premise that it could predict bone regeneration as well.

Dynamic contrast-enhanced EUS for quantification of tumor perfusion in colonic cancer: a prospective cohort study

2018 ◽  
Vol 87 (6) ◽  
pp. 1530-1538 ◽  
Author(s):  
Marie Louise Malmstrøm ◽  
Adrian Săftoiu ◽  
Lene Buhl Riis ◽  
Hazem Hassan ◽  
Tobias Wirenfeldt Klausen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Colonic Cancer ◽  
Tumor Perfusion ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: A dynamic contrast-enhanced MRI study

2009 ◽  
Vol 30 (5) ◽  
pp. 1139-1144 ◽  
Author(s):  
Ya-Feng Zhang ◽  
Yi-Xiang J. Wang ◽  
James F. Griffith ◽  
William K.M. Kwong ◽  
Heather T. Ma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Proximal Femur ◽  
Blood Perfusion ◽  
Hypertensive Rats ◽  
Dynamic Contrast Enhanced ◽  
Femur Bone ◽  
Contrast Enhanced ◽  
Mri Study ◽  
Bone Marrow Blood ◽  
Contrast Enhanced Mri

scholarly journals Measuring Absolute Blood Perfusion in Mice Using Dynamic Contrast-Enhanced Ultrasound

2017 ◽  
Vol 43 (8) ◽  
pp. 1628-1638 ◽  
Author(s):  
Abbas Shirinifard ◽  
Suresh Thiagarajan ◽  
Melissa D. Johnson ◽  
Christopher Calabrese ◽  
András Sablauer
Keyword(s):  
Blood Perfusion ◽  
Contrast Enhanced Ultrasound ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging

2015 ◽  
Vol 16 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Hyun Woo Goo ◽  
Young-Shin Ra
Keyword(s):  
Arterial Spin Labeling ◽  
Vascular Tumor ◽  
Spin Labeling ◽  
Diagnostic Value ◽  
Tumor Perfusion ◽  
Von Hippel Lindau ◽  
Dynamic Contrast Enhanced Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Von Hippel Lindau Disease

Medullary hemangioblastoma is very rare in children. Based on small nodular enhancement with peritumoral edema and without dilated feeding arteries on conventional MRI, hemangioblastoma, pilocytic astrocytoma, oligodendroglioma, and ganglioglioma were included in the differential diagnosis of the medullary tumor. In this case report, the authors emphasize the diagnostic value of arterial spin labeling and dynamic contrast-enhanced MRI in demonstrating vascular tumor perfusion of hemangioblastoma in a 12-year-old boy who was later found to have von Hippel-Lindau disease.

Sign in / Sign up

Export Citation Format

Share Document