Focused Ultrasound Ablation for the Treatment of Patients With Localized Deformed Breast Cancer: Computer Simulation

Abstract This paper is carried out on the computer simulation of breast cancer treated using a high intensity focused ultrasound (HIFU). The mathematical models consist of the pressure acoustics equation, bioheat equation, heat transfer in a blood vessel, momentum equations in a blood vessel, and mechanical deformation equation. In the numerical simulation, these mathematical models are solved by using an axisymmetric finite element method (FEM) with time-dependent, thermal and acoustic properties to describe the temperature distribution and the total displacement in tissue. The comparison of the simulated results in the model with two sizes of the cancer tumor and two frequencies of ultrasound are also considered in order to approach realistic tissue modeling. The results show that the breast cancer model with deformation, which is the more accurate way to simulate the physical characteristics of therapeutic breast cancer compared to the literature results, hence leads to more useful in the medical approach and this study was conducted to prevent errors caused by inaccurate focal points.

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A 2-Fold Interpenetrating Zn(II)-MOF: Sensitive Detection of Fe3+ Ion and Anti-Cancer Activity on Breast Cancer Through high Intensity Focused Ultrasound

Journal of Inorganic and Organometallic Polymers and Materials ◽

10.1007/s10904-021-01921-6 ◽

2021 ◽

Vol 31 (5) ◽

pp. 2209-2217

Author(s):

Jing Huang ◽

Xiao-Yan Pu ◽

Zheng Liu ◽

Xiang-Yun Cao ◽

Jian Fu

Keyword(s):

Breast Cancer ◽

High Intensity ◽

Focused Ultrasound ◽

High Intensity Focused Ultrasound ◽

Sensitive Detection ◽

Anti Cancer ◽

Cancer Activity

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High-intensity focused ultrasonic ablation of breast cancer

Research n Practical Medicine Journal ◽

10.17709/2409-2231-2018-5-3-6 ◽

2018 ◽

Vol 5 (3) ◽

pp. 67-76

Author(s):

L. I. Moskvicheva

Keyword(s):

Breast Cancer ◽

High Intensity ◽

Focused Ultrasound ◽

Malignant Tumors ◽

High Intensity Focused Ultrasound ◽

Ultrasound Therapy ◽

Technical Success ◽

Short Term ◽

Technical Safety ◽

Complete Tumor

Breast cancer is the most frequent and socially signiﬁ cant malignant tumor disease of the female popula on of the Russian Federa on. At present, for the treatment of this pathology, the methods of the organ-preserving surgical manual allowing to achieve the maximum cosme c eﬀ ect along with the observance of the principles of cancer safety are ge ng more and more developed,. In recent decades, researchers from diﬀ erent countries demonstrate the feasibility and technical safety of various mini-invasive methods of thermal abla on of early stages of breast cancer, characterized by rela ve simplicity of implementa on, excellent cosme c results, short-term rehabilita on of pa ents. These include hyperthermic techniques (radiofrequency, microwave, laser abla on) and hypothermic method (cryoabla on). Each technique has unique characteris cs of impact on the tumor and is performed under the control of ultrasound, computer tomography or magne c resonance imaging. The technical success of these abla on techniques is achieved in 93–98% of cases. Complete tumor necrosis a er radiofrequency abla on is observed in 76–100% of pa ents with breast cancer, laser abla on – in 13–76%, microwave abla on – in 0–8%, cryoabla on – in 36–83%. The frequency of development of speciﬁ c complica ons of local thermal destruc on is 4–13%. To date, there is only one method of noninvasive extracorporeal thermal abla on of tumors of diﬀ erent localiza on – high-intensity focused ultrasound therapy, the eﬀ ec veness and safety of which as a method of local destruc on of benign and malignant tumors of the breast demonstrated by many authors. Like all methods of thermal abla on, high-intensity focused ultrasound therapy has its limita ons, complica ons and disadvantages. This ar cle presents a literary review that highlights the possibili es of this method of local destruc on in pa ents with malignant tumors of the breast.

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