Coefficient of Start-Up Friction of Early Stage Osteoarthritic Cartilage Is Not Larger Than Normal Cartilage

2002 ◽  
Author(s):  
Hiromichi Fujie ◽  
Yoji Suzuki ◽  
Michi Ota ◽  
Kiyoshi Mabuchi
Keyword(s):  
Early Stage ◽  
Cruciate Ligament ◽  
Static Friction ◽  
Clinical Situation ◽  
Osteoarthritic Cartilage ◽  
Rabbit Knee ◽  
Start Up ◽  
The Coefficient Of Friction ◽  
Anterior Cruciate ◽  
Acl Transection

It is well known that the disease of osteoarthritis (OA) deteriorates the lubrication properties of articular cartilage. Previous studies [1,2] have demonstrated that the coefficient of friction of rabbit knee cartilage increases significantly in OA models. The coefficient of start-up (static) friction in the normal canine knee joint has also been observed to increase with the duration of static loading [3], and further increases in the start-up friction of osteoarthritic cartilage were induced by surface abrasion and papain injection [4]. However, the change in the start-up friction due to OA disease induced by anterior cruciate ligament (ACL) transection (ACL transection model), has not been fully determined in previous studies, although such a model is considered to display symptoms similar to the clinical situation. Therefore, we investigated the effect of osteoarthritic deterioration on the start-up friction in the ACL transection OA model in the present study.

Neurogenic origin of articular hyperemia in early degenerative joint disease

1999 ◽  
Vol 276 (3) ◽  
pp. R745-R752 ◽  
Author(s):  
Jason J. McDougall ◽  
William R. Ferrell ◽  
Robert C. Bray
Keyword(s):  
Joint Instability ◽  
Cruciate Ligament ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Calcitonin Gene ◽  
Neurogenic Origin ◽  
Vasomotor Activity ◽  
Anterior Cruciate ◽  
Supporting Structures ◽  
Acl Transection

It has been speculated that joint instability resulting from anterior cruciate ligament (ACL) rupture could be exacerbated by changes in vasomotor activity in the remaining supporting structures. In this study, the effect of ACL transection on medial collateral ligament (MCL) basal perfusion and its responsiveness to calcitonin gene-related peptide (CGRP) and sympathetic adrenergic influences was examined. Using urethan-anesthetized rabbits, we tested the effects of CGRP and its antagonist CGRP-(8—37) by topical application of these agents to the exposed knee while sympathetic influences were tested by electrically stimulating the saphenous nerve. It was found that MCL basal perfusion was elevated in ACL-sectioned joints; however, this effect was abrogated by prior resection of the articular nerve supply. At the doses tested, the normal vasodilator response to CGRP was abolished in ACL-sectioned joints, whereas the response to CGRP-(8—37) was attenuated. Even under the influence of increased constrictor tone, MCL and capsule blood vessels still showed substantially reduced responses to exogenous CGRP administration. By contrast, nerve-mediated constrictor responses were mostly unaffected by joint instability. This study suggests that posttraumatic knee joint hyperemia is neurogenically mediated, possibly by increased secretion of CGRP.

scholarly journals Detection of early osteoarthritis in canine knee joints 3 weeks post ACL transection by microscopic MRI and biomechanical measurement

2018 ◽  
Vol 26 (2) ◽  
pp. 230949901877835 ◽  
Author(s):  
Daniel Mittelstaedt ◽  
David Kahn ◽  
Yang Xia
Keyword(s):  
Cruciate Ligament ◽  
Canine Model ◽  
Quantitative Mri ◽  
Early Developmental Stage ◽  
Early Osteoarthritis ◽  
Biomechanical Stress ◽  
Magnetic Resonance Imaging Mri ◽  
Anterior Cruciate ◽  
Transverse Resolution ◽  
Acl Transection

Purpose: To detect early osteoarthritis (OA) in a canine Pond–Nuki model 3 weeks after anterior cruciate ligament (ACL) transection surgery, both topographically over the medial tibial surface and depth-dependently over the cartilage thickness. Methods: Four topographical locations on each OA and contralateral medial tibia were imaged individually by magnetic resonance imaging (MRI) at 17.6 µm transverse resolution. The quantitative MRI T2 relaxation data were correlated with the biomechanical stress-relaxation measurements from adjacent locations. Results: OA cartilage was thinner than the contralateral tissue and had a lower modulus compared to the contralateral cartilage for the exterior, interior, and central medial tibia locations. Depth-dependent and topographical variations were detected in OA cartilage by a number of parameters (compressive modulus, glycosaminoglycan concentration, bulk and zonal thicknesses, T2 at 0° and 55° specimen orientations in the magnet). T2 demonstrated significant differences at varying depths between OA and contralateral cartilage. Conclusion: ACL transection caused a number of changes in the tibial cartilage at 3 weeks after the surgery. The characteristics of these changes, which are topographic and depth-dependent, likely reflect the complex degradation in this canine model of OA at the early developmental stage.

Traumatic Anterior Cruciate Ligament Tear and Its Implications on Meniscal Degradation: A Preliminary Novel Lapine Osteoarthritis Model

2009 ◽  
Author(s):  
Megan L. Killian ◽  
Dan Isaac ◽  
Roger C. Haut ◽  
Loic M. Dejardin ◽  
Darin Leetun ◽  
...  
Keyword(s):  
Complex Dynamics ◽  
Cruciate Ligament ◽  
Experimental Studies ◽  
Acute Injury ◽  
Anterior Cruciate Ligament Tear ◽  
Meniscal Tears ◽  
Ligament Tear ◽  
Anterior Cruciate ◽  
Meniscal Damage ◽  
Acl Transection

The meniscus plays a crucial role in the dynamics of the knee. Damage to the meniscus can influence proprioception, stability, and mobility of the knee [1]. Risk factors of meniscal tears include prolonged or repeated deep knee bending, obesity, and sporting injuries [2]. Acute injury, as seen in alpine sports, involves complex dynamics which can damage singular or multiple tissue structures of the knee [2]. It is not uncommon for meniscal injuries to occur in conjunction with ACL lesions, and the loading imbalance that results in ACL lesions may also initiate meniscal tears [3, 4]. Investigations of meniscal tears following ACL rupture have indicated chronic damage to medial menisci more so than lateral menisci [5]. However, experimental studies of acute damage following ACL transection are not consistent, with some showing more lateral damage acutely and some showing equality between medial and lateral meniscal damage [5].

scholarly journals The underlying mechanism of partial anterior cruciate ligament injuries to the meniscus degeneration of knee joint in rabbit models

2020 ◽  
Author(s):  
Dalin Wang ◽  
Zhe Wang ◽  
Mingcheng Li ◽  
Songbao Xu
Keyword(s):  
Anterior Cruciate Ligament ◽  
Knee Joint ◽  
Cruciate Ligament ◽  
Underlying Mechanism ◽  
Joint Fluid ◽  
Control Group ◽  
Rabbit Knee ◽  
Meniscus Degeneration ◽  
Anterior Cruciate ◽  
Experimental Group

Abstract Background: The diagnosis, treatment and efficacy evaluation of anterior cruciate ligament (ACL) partial rupture remains controversial. This research aims to investigate the underlying mechanism of partial ACL injuries to the meniscus degeneration in the rabbit knee.Methods: Sixty New Zealand, white rabbits were randomly divided into three groups including an experimental group, a sham group (n=6) and and a blank control group (n=6). The experimental group is composed of an anteromedial bundle (AMB) rupture group (n=24), a posterolateral bundle (PLB) rupture group (n=24). Rabbits in the experimental group were subjected to right hind limbs knee surgery to induce ACL part injury under the arthroscopy. Finally, eight rabbits including 6 in the model group and 2 in the control group were sampled randomly on the second, fourth and eighth weeks respectively. We observed the typical form of the meniscus through HE staining. Expressions of inflammatory factors including interleukin-1β (IL-1β) and IL-17 in the knee joint fluid were determined by means of an ELISA. Analysis of the mRNA expressions of matrix metalloproteinases-13(MMP-13) was performed to evaluate the inflammatory mediators in the pathogenesis of the meniscus.Results: HE staining results showed that the surface was rough and the tissues were loose displaying collagen fibers of varying thickness. Both IL-1β and IL-17 in the synovial fluid, and the positive rate of MMP-13 in addition to MMP-13 mRNA showed a demonstrable increase treads from the 2nd to the 8th week. The significant difference was found (P<0.05) compared to the control group.Conclusion: We conclude that the elevated levels of IL-1β and IL-17, along with increased MMP13 expression, resulted in meniscus degradation in the rabbit knee joint model with partial ACL injury.

scholarly journals The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Kyung-Ok Kim ◽  
Jae Ang Sim ◽  
Ji Uk Choi ◽  
Beom Koo Lee ◽  
Hong Gi Park
Keyword(s):  
Anterior Cruciate Ligament ◽  
Anterior Cruciate Ligament Reconstruction ◽  
Ligament Reconstruction ◽  
Early Stage ◽  
Cruciate Ligament ◽  
Joint Fluid ◽  
Cruciate Ligament Reconstruction ◽  
Post Operation ◽  
Anterior Cruciate ◽  
The Relationship

Abstract Purpose We studied the effect of interleukin-8 (IL-8) as the factor for angiogenesis in the joint fluid of remnant-preserved anterior cruciate ligament reconstruction (RP-ACLR). Materials and methods We measured 12 cytokines in joint fluid by multiplex assay and assessed the relationship between IL-8 and vascular endothelial growth factor (VEGF) concentrations. The signal intensity and mean sagittal diameter via postoperative magnetic resonance imaging (MRI) scans were evaluated and the stress X-ray image was analyzed at 3, 6, and 12 months after operation. Results The IL-8 concentration was highest 3 months postoperatively in those patients who underwent RP-ACLR. Clinical data also showed that the signal intensity and stress radiography of the knee graft were significantly better at the early postoperative stage. Discussion Our results show that IL-8 plays an important role in angiogenesis within 3 months after RP-ACLR. This effect yields better recovery after operation. RP-ACLR patients with high knee stability in clinical data were identical to those with high expression of IL-8 in experimental data. Therefore, IL-8 has been shown to help revascularization and ligamentization of the grafted tendon. These results indicate that IL-8 in RP-ACLR is an important factor for angiogenesis after operation. Unfortunately, the relationship of IL-8 and VEGF in vivo has not been studied. Conclusion Our results showed that the IL-8 concentration was very high within 3 months after RP-ACLR operation. The increase in concentration of IL-8 over time was consistent with the increase in VEGF concentration. In the IL-8 clinical setting, MRI analysis showed that ACL synovialization and tension were better in patients who underwent the remnant preservation method. In addition, it was shown that RP-ACLR may be advantageous for early anterior stability within 1 year post operation and beneficial for tendon graft in the early stage post operation. Taken together, our findings suggest that IL-8 may contribute to angiogenesis which is helpful for revascularization and ligamentization of the graft tendon in the early stages of RP-ACLR.

scholarly journals An Anterior Cruciate Ligament In Vitro Rupture Model Based on Clinical Imaging

2021 ◽  
pp. 036354652110171
Author(s):  
Lukas Willinger ◽  
Kiron K. Athwal ◽  
Andy Williams ◽  
Andrew A. Amis
Keyword(s):  
Anterior Cruciate Ligament ◽  
Acl Reconstruction ◽  
Pivot Shift ◽  
Cruciate Ligament ◽  
Acl Injury ◽  
Bone Bruise ◽  
Acl Injuries ◽  
Anterior Cruciate ◽  
Acl Transection

Background: Biomechanical studies on anterior cruciate ligament (ACL) injuries and reconstructions are based on ACL transection instead of realistic injury trauma. Purpose: To replicate an ACL injury in vitro and compare the laxity that occurs with that after an isolated ACL transection injury before and after ACL reconstruction. Study Design: Controlled laboratory study. Methods: Nine paired knees were ACL injured or ACL transected. For ACL injury, knees were mounted in a rig that imposed tibial anterior translation at 1000 mm/min to rupture the ACL at 22.5° of flexion, 5° of internal rotation, and 710 N of joint compressive force, replicating data published on clinical bone bruise locations. In contralateral knees, the ACL was transected arthroscopically at midsubstance. Both groups had ACL reconstruction with bone–patellar tendon–bone graft. Native, ACL-deficient, and reconstructed knee laxities were measured in a kinematics rig from 0° to 100° of flexion with optical tracking: anterior tibial translation (ATT), internal rotation (IR), anterolateral (ATT + IR), and pivot shift (IR + valgus). Results: The ACL ruptured at 26 ± 5 mm of ATT and 1550 ± 620 N of force (mean ± SD) with an audible spring-back tibiofemoral impact with 5o of valgus. ACL injury and transection increased ATT ( P < .001). ACL injury caused greater ATT than ACL transection by 1.4 mm (range, 0.4-2.2 mm; P = .033). IR increased significantly in ACL-injured knees between 0° and 30° of flexion and in ACL transection knees from 0° to 20° of flexion. ATT during the ATT + IR maneuver was increased by ACL injury between 0° and 80° and after ACL transection between 0° and 60°. Residual laxity persisted after ACL reconstruction from 0° to 40° after ACL injury and from 0° to 20° in the ACL transection knees. ACL deficiency increased ATT and IR in the pivot-shift test ( P < .001). The ATT in the pivot-shift increased significantly at 0° to 20° after ACL transection and 0° to 50° after ACL injury, and this persisted across 0° to 20° and 0° to 40° after ACL reconstruction. Conclusion: This study developed an ACL injury model in vitro that replicated clinical ACL injury as evidenced by bone bruise patterns. ACL injury caused larger increases of laxity than ACL transection, likely because of damage to adjacent tissues; these differences often persisted after ACL reconstruction. Clinical Relevance: This in vitro model created more realistic ACL injuries than surgical transection, facilitating future evaluation of ACL reconstruction techniques.

scholarly journals Simulation of Anterior Cruciate Ligament Deficiency in a Musculoskeletal Model with Anatomical Knees

2012 ◽  
Vol 6 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Trent M Guess ◽  
Antonis Stylianou
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Lateral Meniscus ◽  
Musculoskeletal Model ◽  
Dynamics Simulation ◽  
Lateral Side ◽  
Knee Model ◽  
Body Level ◽  
Anterior Cruciate ◽  
Acl Transection

Abnormal knee kinematics and meniscus injury resulting from anterior cruciate ligament (ACL) deficiency are often implicated in joint degeneration even though changes in tibio-femoral contact location after injury are small, typically only a few millimeters. Ligament reconstruction surgery does not significantly reduce the incidence of early onset osteoarthritis. Increased knowledge of knee contact mechanics would increase our understanding of the effects of ACL injury and help guide ACL reconstruction methods. Presented here is a cadaver specific computational knee model combined with a body-level musculoskeletal model from a subject of similar height and weight as the cadaver donor. The knee model was developed in the multi-body framework and includes representation of the menisci. Experimental body-level measurements provided input to the musculoskeletal model. The location of tibio-menisco-femoral contact as well as contact pressures were compared for models with an intact ACL, partial ACL transection (posterolateral bundle transection), and full ACL transection during a muscle driven forward dynamics simulation of a dual limb squat. During the squat, small changes in femur motion relative to the tibia for both partial and full ACL transection push the lateral meniscus in the posterior direction at extension. The central-anterior region of the lateral meniscus then becomes “wedged” between the tibia and femur during knee flexion. This “wedging” effect does not occur for the intact knee. Peak contact pressure and contact locations are similar for the partial tear and complete ACL transection during the deep flexion portion of the squat, particularly on the lateral side. The tibio-femoral contact location on the tibia plateau shifts slightly to the posterior and lateral direction with ACL transection.

Sign in / Sign up

Export Citation Format

Share Document