Simulation Based Optimization of Microfluidic Devices Used for Molecular Enrichment

2012 ◽  
Author(s):  
Hui Xia ◽  
Bobby Mathew ◽  
Hisham Hegab ◽  
June Feng
Keyword(s):  
Mass Transfer ◽  
Pressure Drop ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Stokes Equations ◽  
Microfluidic Devices ◽  
Geometric Parameters ◽  
Operating Parameters ◽  
Inlet Concentration ◽  
Advection Diffusion Equation

Microfluidic devices are used in several engineering fields ranging from biomedical to chemical to engineering for applications such as micro reactor, target molecular enriching and cell capturing. With regard to related applications, microfluidic devices offer advantages such as high surface area to volume ratio, increased mass transfer coefficient and portability in addition to their requirement of low analytes. Affinity based microfluidic devices with microscale posts have high compactness and mass transfer coefficient. In order to maximize the benefits offered by employing microfluidic devices, it is important to apply parametric study in the device designing work. This study is aimed at studying the operating and geometric parameters of microfluidic devices with square/rectangular microscale posts. The geometric parameters, such as aspect ratio of the microposts used, could possibly decide the performance of the device. Operating parameters studied are Reynolds number, Peclet number, Damköhler number, and equilibrium reaction constant. These parameters encompass the influence of velocity, diffusivity, density, viscosity, hydraulic diameter, inlet concentration of species and absorption/desorption reaction constants. This work theoretically analyzes the influence of the above mentioned parameters using COMSOL Multiphysics 4.2.a. The governing equations of microfluidic devices, i.e. Navier-Stokes equations and the advection-diffusion equation, subjected to the above mentioned operating parameters, are solved to obtain the velocity profile, pressure drop and concentration profile of the species. The metric used for analyzing the influence of each operating parameter is the capture efficiency, i.e. the ratio of outlet concentration to inlet concentration as well the pressure drop. The results of this study would improve the design of microfluidic devices used for chemical reactions as well as that used for protein enrichment.

scholarly journals Pressure drop and volumetric gas-phase mass transfer coefficient in a column packed with impulse packing.

1982 ◽  
Vol 15 (1) ◽  
pp. 63-66
Author(s):  
MOMINUDDIN CHOWDHURY ◽  
TAKESHI ISHIKAWA ◽  
KUNIO NAGAHAMA ◽  
MITSUHO HIRATA
Keyword(s):  
Mass Transfer ◽  
Pressure Drop ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Gas Phase

scholarly journals Packed bed absorption column: Hydrodynamics and mass transfer

2019 ◽  
pp. 260-267
Author(s):  
Milan Sovilj ◽  
Branislava Nikolovski ◽  
Momcilo Spasojevic ◽  
Sinisa Mauhar
Keyword(s):  
Mass Transfer ◽  
Pressure Drop ◽  
Transfer Coefficient ◽  
Mass Transfer Coefficient ◽  
Flow Rate ◽  
Gas Mixture ◽  
Countercurrent Flow ◽  
Air Velocity ◽  
Absorption Column ◽  
Overall Mass Transfer Coefficient

This paper presents the results of the determination of the hydrodynamic characteristics and mass transfer in the pilot plate absorption column. The experimental values of the pressure drop in the countercurrent flow of air and water through the column were obtained. The graphic dependence of the pressure drop of air per unit height of the layer of packing (?P/h) on the apparent air velocity (Ug) through the dry charge was shown to be in the form of a quadratic function. From the graphical function which shows the dependence of the pressure drop per unit height of the layer of filling (?P/m) on the apparent air velocity during the countercurrent flow of the phases (water and air), three fields of the interaction of the phases were observed: a) the area of low load, at low apparent air velocities, b) the area of high load, at higher air velocities, and c) the flooding area, when the liquid completely fills the cavities and the working gas in them starts bubbling. The overall mass transfer coefficient (Kg) of the air-CO2-water system depends on the flow rate of the gaseous phase and the composition of the starting gas mixture (air-CO2). With the increase in the total gas flow rate, with a constant composition of the starting gas mixture and constant fluid flow, the overall mass transfer coefficient increases. Increasing the amount of CO2 in the starting gas mixture at a constant flow rate of fluid and a constant ratio of the molar flow of the inert in the liquid and the gas-phase (L'/G') decreases the overall mass transfer coefficient.

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