Typical Patterns, Atypical Events, and Uncertainty in Complex Systems

2011 ◽  
Author(s):  
Brett G. Amidan ◽  
Thomas A. Ferryman
Keyword(s):  
Complex System ◽  
Adverse Events ◽  
Complex Systems ◽  
Power Grid ◽  
Aviation Safety ◽  
The Novel ◽  
Domain Experts ◽  
Uncertainty Characterization ◽  
Random Uncertainty

The power grid is a complex system. Multiple quantities are measured from hundreds of locations, at rates up to 30 Hz. There are both correlated and uncorrelated variables. Powerful methods are needed to examine this large amount of data and better understand the complex system, and in the case of the power grid, identify imminent adverse events, such as blackouts. These methods need to sift through any multicollinearity among the variables, account for the random uncertainty that is present within each variable, and focus on practical differences as defined by domain experts in addition to statistical differences. These methods will then help the user to better understand the complex system by uncovering the hidden gems within the data. These gems include identification of the uncertainty, characterization of the typical patterns, and the discovery of atypical events. This paper will discuss the intricate methods used to explore the data, and the novel displays used to communicate the findings. This paper will also delve into the exploration of other complex systems, like aviation safety, using similar methods.

Developing Biomimetic Guidelines for the Highly Optimized and Robust Design of Complex Products or Their Components

2010 ◽  
Author(s):  
Anosh P. Wadia ◽  
Daniel A. McAdams
Keyword(s):  
Complex System ◽  
Complex Systems ◽  
Information Transfer ◽  
Design Guidelines ◽  
Design Problems ◽  
Biomimetic Design ◽  
Biological Domain ◽  
The Face ◽  
Complex System Design

Improved complex system design methods can lead to innovative, efficient, and robust product designs. This research aims at improving the design of products that compose a portion of, or exist within, a complex system. Before attempting to improve product designs, one requires a better understanding and characterization of complex systems. One method to characterize optimized and robust complex systems is to use the Theory of Highly Optimized Tolerance (HOT). The theory states that highly optimized and tolerant complex systems are robust in conditions for which they were designed, but fragile in the face of unanticipated events. Highly robust and optimized complex systems are abundant in the biological domain. In fact, nature represents a vast resource for innovative solutions to varied design problems. Leveraging these solutions to solve engineering problems is often referred to as biomimetic design. This research analyzes twenty bio-inspired engineering products including the biological system from which they were derived. The HOT theory is used analyze the biomimetic systems and identify the inherent characteristics that make the designs robust to their environment. These characteristics were reviewed to identify common features and trends present within the information transfer between the biological and engineering domains. Finally, the inferred features and trends were abstracted into usable guidelines stated as nine biomimetic design guidelines. Similar to the forty Theory of Inventive Problem Solving principles, these bio-inspired guidelines could aid engineers in developing innovative and robust solutions to design problems. In fact, a similarity between some of the biomimetic design guidelines and TRIZ principles is observed. This correlation suggests that solutions perceived as innovative in the engineering domain match those in nature.

Characterization of Complex Systems by Aperiodic Driving Forces

1989 ◽  
Author(s):  
Daniel Bensen ◽  
Michael Welge ◽  
Alfred Huebler ◽  
Norman Packard
Keyword(s):  
Complex Systems ◽  
Driving Forces

Characterization of the novel HLA‐C *07:944 allele by next‐generation sequencing

HLA ◽  
2021 ◽  
Author(s):  
Maria Loginova ◽  
Olga Makhova ◽  
Daria Smirnova ◽  
Igor Paramonov ◽  
Maksim Zarubin
Keyword(s):  
Next Generation Sequencing ◽  
The Novel ◽  
Next Generation ◽  
Generation Sequencing

Characterization of the novel HLA‐B *51:296 allele by next‐generation sequencing

HLA ◽  
2020 ◽  
Author(s):  
Steve Genebrier ◽  
Vincent Elsermans ◽  
Emeric Texeraud ◽  
Gerald Bertrand ◽  
Virginie Renac
Keyword(s):  
Next Generation Sequencing ◽  
The Novel ◽  
Next Generation ◽  
Generation Sequencing

Characterization of the novel HLA‐DRB1*11:282 allele by sequencing‐based typing

HLA ◽  
2021 ◽  
Author(s):  
Marine Cargou ◽  
Vincent Elsermans ◽  
Isabelle Top ◽  
Laura Blouin ◽  
Jonathan Visentin
Keyword(s):  
The Novel

scholarly journals Isolation and Characterization of Salmonella Jumbo-Phage pSal-SNUABM-04

Viruses ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 27
Author(s):  
Jun Kwon ◽  
Sang Guen Kim ◽  
Hyoun Joong Kim ◽  
Sib Sankar Giri ◽  
Sang Wha Kim ◽  
...  
Keyword(s):  
Morphological Traits ◽  
Open Reading Frames ◽  
Genome Comparison ◽  
The Novel ◽  
Promising Alternative ◽  
Isolation And Characterization ◽  
Global Issue ◽  
Reading Frames ◽  
Predicted Function

The increasing emergence of antimicrobial resistance has become a global issue. Therefore, many researchers have attempted to develop alternative antibiotics. One promising alternative is bacteriophage. In this study, we focused on a jumbo-phage infecting Salmonella isolated from exotic pet markets. Using a Salmonella strain isolated from reptiles as a host, we isolated and characterized the novel jumbo-bacteriophage pSal-SNUABM-04. This phage was investigated in terms of its morphology, host infectivity, growth and lysis kinetics, and genome. The phage was classified as Myoviridae based on its morphological traits and showed a comparatively wide host range. The lysis efficacy test showed that the phage can inhibit bacterial growth in the planktonic state. Genetic analysis revealed that the phage possesses a 239,626-base pair genome with 280 putative open reading frames, 76 of which have a predicted function and 195 of which have none. By genome comparison with other jumbo phages, the phage was designated as a novel member of Machinavirus composed of Erwnina phages.

Characterization of the novel HLA‐DQA1 *05:19 allele by next‐generation sequencing

HLA ◽  
2021 ◽  
Author(s):  
Steve Genebrier ◽  
Paul Rouzaire ◽  
Emeric Texeraud ◽  
Gerald Bertrand ◽  
Virginie Renac
Keyword(s):  
Next Generation Sequencing ◽  
The Novel ◽  
Next Generation ◽  
Hla Dqa1 ◽  
Generation Sequencing

scholarly journals Comparison of the Diagnostic Performance of Novel Slim Biopsy Forceps with Conventional Biopsy Forceps for Biliary Stricture: A Multicenter Retrospective Study

2021 ◽  
Vol 11 (1) ◽  
pp. 55
Author(s):  
Eun Suk Jung ◽  
Se Woo Park ◽  
Jung Hee Kim ◽  
Jang Han Jung ◽  
Min Jae Yang ◽  
...  
Keyword(s):  
Adverse Events ◽  
Predictive Value ◽  
Diagnostic Performance ◽  
Biliary Stricture ◽  
Accurate Diagnosis ◽  
The Novel ◽  
Biopsy Forceps ◽  
Tertiary Hospitals ◽  
Tissue Acquisition ◽  
Histological Confirmation

Novel slim biopsy forceps provide some technical advantages to facilitate a more accurate diagnosis, although we are not aware of any comparative studies. Therefore, we compared tissue acquisition and diagnostic accuracy between novel slim biopsy forceps and conventional biopsy forceps in cases with a biliary stricture. We reviewed 341 patients who underwent endoscopic retrograde cholangiopancreatography for the histological confirmation of biliary stricture at two tertiary hospitals between 2013 and 2020. The primary endpoint was the forceps’ diagnostic accuracies. We included 276 patients who underwent biopsy using the novel forceps (n = 130) or conventional forceps (n = 146). The novel forceps provided 81.7% sensitivity, 100.0% specificity, positive-predictive value (PPV) of 100.0%, and negative-predictive value (NPV) of 57.8%, with an accuracy of 85.4% when the diagnosis by endobiliary biopsy included suspected or positive malignancy. The conventional forceps provided 61.7% sensitivity, 100.0% specificity, PPV of 100.0%, and NPV of 36.1%, with an accuracy of 68.5%. Only novel forceps use was significantly associated with an accurate diagnosis (odds ratio: 2.70, 95% confidence interval: 1.52–5.00). There were no significant inter-group differences in the procedure-related rates of adverse events. Endobiliary biopsy using novel forceps offered better diagnostic performance and more acceptable procedure-related adverse events than conventional forceps.

Characterization of the novel HLA‐C *05:01:58 allele by sequencing‐based typing

HLA ◽  
2021 ◽  
Author(s):  
Lucie Blandin ◽  
Gwendaline Guidicelli ◽  
Laura Blouin ◽  
Richard Lemal ◽  
Paul Rouzaire
Keyword(s):  
The Novel
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