Shear Stress Modulates Plaque Composition in Human Coronary Arteries In Vivo

2008 ◽  
Author(s):  
Frank Gijsen ◽  
Jolanda Wentzel ◽  
Johan Schuurbiers ◽  
Frits Mastik ◽  
Johannes Schaar ◽  
...  
Keyword(s):  
Shear Stress ◽  
Atherosclerotic Plaques ◽  
Plaque Composition ◽  
Low Shear Stress ◽  
Advanced Stages ◽  
Shear Stress And Strain ◽  
Stress Influences ◽  
The Relationship ◽  
Low Shear

It is well established that atherosclerotic plaques generally develop in low shear stress regions, including curved arterial segments and bifurcations1. Once these plaques intrude into the lumen, the shear stress they are exposed to alters with hitherto unknown consequences. We hypothesize that in the more advanced stages of the disease, shear stress has an important impact on plaque composition in such a way that high shear stress enhances plaque vulnerability through its biological impact on the endothelium2. We investigated this hypothesis previously by studying the relationship between shear stress and strain, a marker for plaque composition, in human coronary arteries3. In this study, we will extend that study by investigating how shear stress influences changes of strain, and thus plaque composition, over a period of 6 months.

Strain Distribution Over Plaques in Human Coronary Arteries Relates to Shear Stress

2007 ◽  
Author(s):  
Frank J. H. Gijsen ◽  
Jolanda J. Wentzel ◽  
Johan C. H. Schuurbiers ◽  
Antonius F. W. van der Steen ◽  
Patrick W. Serruys
Keyword(s):  
Shear Stress ◽  
Coronary Arteries ◽  
Atherosclerotic Plaques ◽  
Plaque Composition ◽  
Biological Impact ◽  
Low Shear Stress ◽  
Advanced Stages ◽  
Shear Stress And Strain ◽  
The Relationship ◽  
Low Shear

It is well established that atherosclerotic plaques generally develop in low shear stress regions, including curved arterial segments and bifurcations. Once these plaques intrude into the lumen, the shear stress they are exposed to alters with hitherto unknown consequences. We hypothesize that in the more advanced stages of the disease, shear stress has an important impact on plaque composition in such a way that high shear stress enhances plaque vulnerability through its biological impact on the endothelium. We investigated this hypothesis by studying the relationship between shear stress and strain, a marker for plaque composition, in human coronary arteries.

Plaque and Shear Stress Distribution in Human Coronary Bifurcations: a Multi-Slice Computed Tomography Study

2007 ◽  
Author(s):  
Alina G. van der Giessen ◽  
Jolanda J. Wentzel ◽  
Frans N. van de Vosse ◽  
Antonius F. van der Steen ◽  
Pim J. de Feyter ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Shear Stress ◽  
Outer Wall ◽  
Atherosclerotic Plaques ◽  
Advanced Stage ◽  
Flow Divider ◽  
Low Shear Stress ◽  
Curved Vessels ◽  
Early Atherosclerosis ◽  
Low Shear

It is generally accepted that early atherosclerosis develops in low shear-stress (SS) regions such as the outer wall of arterial bifurcations and the inner bend of curved vessels (1). However, in clinical practice, it is common to observe atherosclerotic plaques at the flow-divider, or carina, of coronary bifurcations (2). Plaques at the carina are more frequently found in symptomatic patients, and may represent a more advanced stage of atherosclerosis. The carina is located in a region which is exposed to high SS. We hypothesize that if plaques are located in atheroprotective high SS regions, they have grown circumferentially from the atherogenic low SS regions.

Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice

2013 ◽  
Vol 227 (2) ◽  
pp. 236-243 ◽  
Author(s):  
Vania C. Olivon ◽  
Rodrigo A. Fraga-Silva ◽  
Dolf Segers ◽  
Céline Demougeot ◽  
Ana M. de Oliveira ◽  
...  
Keyword(s):  
Shear Stress ◽  
Atherosclerotic Plaques ◽  
Low Shear Stress ◽  
Low Shear

Numerical Simulation of Blood Flow in the Renal Arteries: Influence of the Ostium Flow Diverter

2013 ◽  
Author(s):  
Scott Albert ◽  
Jenn Stroud Rossmann ◽  
Robert Balaban
Keyword(s):  
Shear Stress ◽  
Vessel Wall ◽  
Flow Diverter ◽  
Atherosclerotic Plaques ◽  
Residence Times ◽  
Branch Points ◽  
Tissue Microenvironment ◽  
Low Shear Stress ◽  
Arterial Branch ◽  
Low Shear

The tendency of atherosclerotic plaques to develop at arterial branch points is likely due to both the hemodynamics and macromolecular environment associated with these branch points. Arterial branches experience flow separation, which results in regions of low shear stress[1–3], and contributes to longer residence times that may allow for deposition of pro-atherogenic material in the vessel wall [2]. In addition, low shear stress itself may provide cellular signals that alter the tissue microenvironment in favor of atherogenesis [3, e.g.].

Study on the relationship between plaque composition and shear stress in human coronary arteries in vivo

2006 ◽  
Vol 39 ◽  
pp. S280
Author(s):  
J. Wentzel ◽  
F.J.H. Gijsen ◽  
J.C.H. Schuurbiers ◽  
H.M. Garcia-Garcia ◽  
A.F.W. van der Steen ◽  
...  
Keyword(s):  
Shear Stress ◽  
Coronary Arteries ◽  
Plaque Composition ◽  
The Relationship

Fusion of Histology and Shear Stress Based on In Vivo Images

2009 ◽  
Author(s):  
Harald C. Groen ◽  
Theo van Walsum ◽  
Frank J. H. Gijsen ◽  
Sietske Rozie ◽  
Stefan Klein ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Shear Stress ◽  
Plaque Rupture ◽  
Plaque Composition ◽  
Essential Step ◽  
Histological Processing ◽  
Plaque Destabilization ◽  
The Relationship

Evidence is accumulating for a role of high wall shear stress (WSS) in plaque destabilization, leading to plaque rupture [1–2]. To study this in detail we can use carotid plaques that are removed during surgery. The in vivo WSS distribution can be obtained by combining 3D lumen data, derived from pre-operative CT angiography (CTA) imaging, with computational fluid dynamics. Plaque composition can be studied by means of histological processing. Accurate registration of CT imaging with histology is an essential step to study the relationship between WSS and plaque composition.

Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques

2015 ◽  
Vol 89 ◽  
pp. 168-172 ◽  
Author(s):  
Anusha N. Seneviratne ◽  
Jennifer E. Cole ◽  
Michael E. Goddard ◽  
Inhye Park ◽  
Zahra Mohri ◽  
...  
Keyword(s):  
Shear Stress ◽  
Macrophage Polarization ◽  
Atherosclerotic Plaques ◽  
M1 Macrophage ◽  
Low Shear Stress ◽  
Low Shear

Necrotic Core in Advanced Atherosclerotic Plaques in Human Coronaries Is Exposed to Elavated Shear Stress

2009 ◽  
Author(s):  
Frank Gijsen ◽  
Johan Schuurbiers ◽  
Harald Groen ◽  
Nieves Gonzales ◽  
Patrick Serruys ◽  
...  
Keyword(s):  
Shear Stress ◽  
Vascular Remodeling ◽  
Ulcer Formation ◽  
Plaque Development ◽  
Lumen Narrowing ◽  
Low Shear Stress ◽  
Plaque Destabilization ◽  
Stress Influences ◽  
Early Atherosclerosis ◽  
Low Shear

In early atherosclerosis, plaques localize in low shear stress regions. During plaque development, the lumen of the artery remains patent due to vascular remodeling and unfavorable low shear stress conditions can persist. Consequently, a continuous influx of lipids can be anticipated in these regions, possibly leading to the development vulnerable plaques. If the plaque exceeds a certain size, vascular remodeling will not be able to maintain the lumen dimensions and the plaque will cause lumen narrowing. This is generally accompanied by shear stress increase in certain regions of the plaque. Evidence is accumulating that increased levels of shear stress influences plaque composition in such a way that it might induce plaque destabilization and ulcer formation.

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