scholarly journals Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer

2007 ◽  
Vol 12 (1) ◽  
pp. 010501 ◽  
Author(s):  
Roger J. Zemp ◽  
Rachel Bitton ◽  
Meng-Lin Li ◽  
K. Kirk Shung ◽  
George Stoica ◽  
...  
Keyword(s):  
High Frequency ◽  
Photoacoustic Imaging ◽  
High Frequency Ultrasound ◽  
Array Transducer ◽  
Frequency Ultrasound

scholarly journals Monitoring of Adult Zebrafish Heart Regeneration Using High-Frequency Ultrasound Spectral Doppler and Nakagami Imaging

Sensors ◽  
2019 ◽  
Vol 19 (19) ◽  
pp. 4094 ◽  
Author(s):  
Sunmi Yeo ◽  
Changhan Yoon ◽  
Ching-Ling Lien ◽  
Tai-Kyong Song ◽  
K. Kirk Shung
Keyword(s):  
High Frequency ◽  
Doppler Imaging ◽  
Adult Zebrafish ◽  
High Frequency Ultrasound ◽  
In Vivo Experiments ◽  
Longitudinal Measurements ◽  
Array Transducer ◽  
Spectral Doppler ◽  
Frequency Ultrasound

This paper reports the feasibility of Nakagami imaging in monitoring the regeneration process of zebrafish hearts in a noninvasive manner. In addition, spectral Doppler waveforms that are typically used to access the diastolic function were measured to validate the performance of Nakagami imaging. A 30-MHz high-frequency ultrasound array transducer was used to acquire backscattered echo signal for spectral Doppler and Nakagami imaging. The performances of both methods were validated with flow and tissue-mimicking phantom experiments. For in vivo experiments, both spectral Doppler and Nakagami imaging were simultaneously obtained from adult zebrafish with amputated hearts. Longitudinal measurements were performed for five zebrafish. From the experiments, the E/A ratio measured using spectral Doppler imaging increased at 3 days post-amputation (3 dpa) and then decreased to the value before amputation, which were consistent with previous studies. Similar results were obtained from the Nakagami imaging where the Nakagami parameter value increased at 3 dpa and decreased to its original value. These results suggested that the Nakagami and spectral Doppler imaging would be useful techniques in monitoring the regeneration of heart or tissues.

scholarly journals Photoacoustic/Ultrasound/Optical Coherence Tomography Evaluation of Melanoma Lesion and Healthy Skin in a Swine Model

Sensors ◽  
2019 ◽  
Vol 19 (12) ◽  
pp. 2815 ◽  
Author(s):  
Karl Kratkiewicz ◽  
Rayyan Manwar ◽  
Ali Rajabi-Estarabadi ◽  
Joseph Fakhoury ◽  
Jurgita Meiliute ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
High Frequency ◽  
Photoacoustic Imaging ◽  
Diagnostic Methods ◽  
Swine Model ◽  
Optical Coherence ◽  
Healthy Skin ◽  
High Frequency Ultrasound ◽  
Rapid Drop ◽  
Frequency Ultrasound

The marked increase in the incidence of melanoma coupled with the rapid drop in the survival rate after metastasis has promoted the investigation into improved diagnostic methods for melanoma. High-frequency ultrasound (US), optical coherence tomography (OCT), and photoacoustic imaging (PAI) are three potential modalities that can assist a dermatologist by providing extra information beyond dermoscopic features. In this study, we imaged a swine model with spontaneous melanoma using these modalities and compared the images with images of nearby healthy skin. Histology images were used for validation.

scholarly journals In vivo imaging of swimming micromotors using hybrid high-frequency ultrasound and photoacoustic imaging

2020 ◽  
Author(s):  
Azaam Aziz ◽  
Joost Holthof ◽  
Sandra Meyer ◽  
Oliver G. Schmidt ◽  
Mariana Medina-Sánchez
Keyword(s):  
High Frequency ◽  
Imaging System ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Imaging Techniques ◽  
High Frequency Ultrasound ◽  
Living Organisms ◽  
And Function ◽  
Frequency Ultrasound

AbstractThe fast evolution of medical micro- and nanorobots in the endeavor to perform non-invasive medical operations in living organisms boosted the use of diverse medical imaging techniques in the last years. Among those techniques, photoacoustic (PA) tomography has shown to be promising for the imaging of microrobots in deep-tissue (ex vivo and in vivo), as it possesses the molecular specificity of optical techniques and the penetration depth of ultrasound imaging. However, the precise maneuvering and function control of microrobots, in particular in living organisms, demand the combination of both anatomical and functional imaging methods. Therefore, herein, we report the use of a hybrid High-Frequency Ultrasound (HFUS) and PA imaging system for the real-time tracking of magnetically driven micromotors (single and swarms) in phantoms, ex vivo, and in vivo (in mice bladder and uterus), envisioning their application for targeted drug-delivery.

scholarly journals Bedside Differentiation Between Benign and Malignant Pigmented Skin Tumours by Four Diagnostic Imaging Technologies – A Pilot Study

2021 ◽  
Author(s):  
Terese Von Knorring ◽  
Niels Møller Israelsen ◽  
Vilde Ung ◽  
Julie L. Formann ◽  
Mikkel Jensen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
High Frequency ◽  
Photoacoustic Imaging ◽  
Skin Lesions ◽  
Reflectance Confocal Microscopy ◽  
Optical Coherence ◽  
High Frequency Ultrasound ◽  
Skin Tumours ◽  
Frequency Ultrasound

Fast diagnosis of suspicious pigmented skin lesions is imperative, but current bedside skin imaging technologies are either limited in penetration depth or resolution. Combining imaging methods is therefore highly relevant for skin cancer diagnostics. This pilot study evaluates the ability of optical coherence tomography, reflectance confocal microscopy, photoacoustic imaging and high-frequency ultrasound to differentiate malignant from benign pigmented skin lesions. A total of 41 pigmented skin tumours were scanned prior to excision. Morphologic features and blood vessel characteristics were analysed in reflectance confocal microscopy, optical coherence tomography, high-frequency ultrasound and photoacoustic imaging images and diagnostic accuracy assessed. Three novel photoacoustic imaging features, 7 reflectance confocal microscopy features and two optical coherence tomography features were detected with a high correlation to malignancy, diagnostic accuracy > 71%. No significant features were found in high-frequency ultrasound. Conclusively, optical coherence tomography, reflectance confocal microscopy and photoacoustic imaging in combination enables image-guided evaluation of suspicious pigmented skin tumours at the bedside. Combining these advanced techniques may help to diagnose skin cancer more efficiently.

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