Purpose. In this article, the authors propose useful operational indications to approach in the best possible way the issues concerning the design of a facility for manufacturing radiopharmaceuticals, with focus on organizational and safety aspects. Methods. Several documents produced by authoritative bodies, national and international scientific institutions and associations were examined and referenced, to the purpose of reviewing all available information in the field. Results. Indications are gathered for the design stage, including the organization of accesses and routes and characteristics and requirements of premises and systems. Conclusions. Main goal is to guide the reader in evaluating and choosing the most suitable features and equipment to limit the risks due to ionizing radiation and to prevent contamination of the workers and the environment.